Multiple imaging mode tissue marker
First Claim
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1. An intracorporeal marker, for marking a site within living tissue of a host, comprising:
- a body comprised of first and second distinct materials, the body having a core region made of the first material completely surrounded by an outer region made of the second material, the first material being comprised of porous hydroxyapatite having physical properties that permit the body to be distinguished from human soft tissue under visualization using ultrasonic and radiation imaging modalities, the second material being comprised of a second hydroxyapatite, and wherein the porous hydroxyapatite of the core region has a first porosity and the second hydroxyapatite of the outer region has a second porosity, wherein the first porosity of the porous hydroxyapatite of the core region is higher than the second porosity of the second hydroxyapatite of the outer region.
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Abstract
An intracorporeal marker for marking a site within living tissue of a host having a body of porous hydroxyapatite whose physical properties permit the body to be distinguished from human soft tissue under visualization using ultrasonic and radiation imaging modalities.
508 Citations
11 Claims
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1. An intracorporeal marker, for marking a site within living tissue of a host, comprising:
a body comprised of first and second distinct materials, the body having a core region made of the first material completely surrounded by an outer region made of the second material, the first material being comprised of porous hydroxyapatite having physical properties that permit the body to be distinguished from human soft tissue under visualization using ultrasonic and radiation imaging modalities, the second material being comprised of a second hydroxyapatite, and wherein the porous hydroxyapatite of the core region has a first porosity and the second hydroxyapatite of the outer region has a second porosity, wherein the first porosity of the porous hydroxyapatite of the core region is higher than the second porosity of the second hydroxyapatite of the outer region. - View Dependent Claims (2, 3, 4)
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5. An intracorporeal marker for marking a site within living tissue of a host, comprising:
a porous body having a central region and a surface that surrounds the central region, the body having pores filled with gas, the sizes of the pores and the gas being such that the body is configured to be visualized under ultrasound, wherein the porous body comprises a first dense hydroxyapatite at the central region, a second dense hydroxyapatite at the surface, and a porous hydroxyapatite between the central region and the surface, and wherein the porous hydroxyapatite has porosity levels in a range of 30 percent to 80 percent. - View Dependent Claims (6)
- 7. An intracorporeal tissue marker, comprising first and second distinct materials, the first material comprising a core of the marker and having a first density, the second material completely surrounding the first material and having a second density, the first density being lower than the second density, and wherein each of the first material and the second material comprises hydroxyapatite.
Specification