Microporation of tissue for delivery of bioactive agents
First Claim
1. A device for ablating stratum corneum of skin on the body of a subject, comprising:
- a plurality of heat probes, which are each formed from a thin layer and adapted to be applied to the skin of the subject at respective points; and
a power source, which is adapted (i) to deliver sufficient thermal energy to at least one of the plurality of the heat probes such that the at least one of the plurality of the heat probes is cycled through a series of one or more modulations of temperature from an initial point of ambient temperature to a peak temperature in excess of 123°
C., and back to ambient surface temperature, and (ii) to apply electrical energy to at least one of the plurality of heat probes so as to induce an electrical current to flow through the stratum corneum, causing ablation of narrow channels through the stratum corneum at the respective points.
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Accused Products
Abstract
A method of enhancing the permeability of a biological membrane, including the skin or mucosa of an animal or the outer layer of a plant to a permeant is described utilizing microporation of selected depth and optionally one or more of sonic, electromagnetic, mechanical and thermal energy and a chemical enhancer. Microporation is accomplished to form a micropore of selected depth in the biological membrane and the porated site is contacted with the permeant. Additional permeation enhancement measures may be applied to the site to enhance both the flux rate of the permeant into the organism through the micropores as well as into targeted tissues within the organism.
121 Citations
35 Claims
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1. A device for ablating stratum corneum of skin on the body of a subject, comprising:
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a plurality of heat probes, which are each formed from a thin layer and adapted to be applied to the skin of the subject at respective points; and a power source, which is adapted (i) to deliver sufficient thermal energy to at least one of the plurality of the heat probes such that the at least one of the plurality of the heat probes is cycled through a series of one or more modulations of temperature from an initial point of ambient temperature to a peak temperature in excess of 123°
C., and back to ambient surface temperature, and (ii) to apply electrical energy to at least one of the plurality of heat probes so as to induce an electrical current to flow through the stratum corneum, causing ablation of narrow channels through the stratum corneum at the respective points. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A device for ablating stratum corneum of skin on the body of a subject, comprising:
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a housing having a surface that defines a storage region adapted to store an active substance;
a plurality of heat probes, which are each formed from a thin layer and adapted to be applied to the skin of the subject at respective points; anda power source, which is adapted (i) to deliver sufficient thermal energy to at least one of the plurality of the heat probes such that the at least one of the plurality of the heat probes is cycled through a series of one or more modulations of temperature from an initial point of ambient temperature to a peak temperature in excess of 123°
C., and back to ambient surface temperature, and (ii) to apply electrical energy between two or more of the plurality of heat probes, to cause ablation of an area of the stratum corneum so as to facilitate passage of the active substance through the ablated area. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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32. A device for ablating stratum corneum of skin of a subject, comprising:
- a plurality of heat probes, which are each formed from a thin layer and adapted to be applied to the skin of the subject at respective points on the skin confined to a small area less than 1000 μ
m;
a housing having a surface that defines a storage region adapted to store an active substance; and
a power source adapted (i) to deliver sufficient thermal energy to at least one of the plurality of the heat probes such that the at least one of the plurality of the heat probes is cycled through a series of one or more modulations of temperature from an initial point of ambient temperature to a peak temperature in excess of 123°
C., and back to ambient surface temperature, and (ii) to apply electrical energy between two of the plurality of heat probes applied to the skin to cause ablation of the stratum corneum, so as to facilitate passage of the active substance through the skin. - View Dependent Claims (33, 34, 35)
- a plurality of heat probes, which are each formed from a thin layer and adapted to be applied to the skin of the subject at respective points on the skin confined to a small area less than 1000 μ
Specification