Auto-injector

• US 9,579,459 B2
• Filed: 12/21/2011
• Issued: 02/28/2017
• Est. Priority Date: 12/21/2010
• Status: Active Grant

• Current Assignee: Shl Medical AG
• Original Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Inventors: Jennings, Douglas, Kemp, Thomas, Ekman, Matthew
• Primary Examiner(s): Hayman, Imani
• Assistant Examiner(s): DARB, HAMZA A.
• Application Number:
  US13/994,888
• Publication Number:
  US 20130274655A1
• Time in Patent Office: 1,896 Days
• US Class Current: 1/1
• CPC Class Codes: A61M 2005/206 With automatic needle insertion
• CPC Class Codes: A61M 2005/2073 preventing premature release, e.g. by making use of a safety lock
• CPC Class Codes: A61M 2005/208 Release is possible only when device is pushed against the skin, e.g. using a trigger which is blocked or inactive when the device is not pushed against the skin
• CPC Class Codes: A61M 2005/2488 via rotation, e.g. threads or bayonet
• CPC Class Codes: A61M 2005/31588 electrically driven
• CPC Class Codes: A61M 2205/14 Detection of the presence or absence of a tube, a connector or a container in an apparatus
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 2205/6018 providing set-up signals for the apparatus configuration
• CPC Class Codes: A61M 2205/6054 Magnetic identification systems
• CPC Class Codes: A61M 2205/6072 Bar codes
• CPC Class Codes: A61M 2207/00 Methods of manufacture, assembly or production
• CPC Class Codes: A61M 5/20 Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically A61M5/142 , A61M5/46 take precedence; hypodermic projectiles F42B12/54
• CPC Class Codes: A61M 5/24 Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/3204 Needle cap remover, i.e. devices to dislodge protection cover from needle or needle hub, e.g. deshielding devices
• CPC Class Codes: A61M 5/3213 Caps placed axially onto the needle, e.g. equipped with finger protection guards axially-extensible protective sleeves A61M5/3243
• CPC Class Codes: A61M 5/326 Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user
• CPC Class Codes: A61M 5/46 having means for controlling depth of insertion

Abstract

The invention relates to an auto-injector (A) for administering a dose of a liquid medicament, comprising of a substantially tubular front-end device adapted to contain a syringe with an injection needle and a barrel containing the dose of the medicament and comprising a needle shroud adapted to rest on the skin of a patient receiving an injection and a reusable back-end device comprising of a housing, a plunger connected to or adapted to engage a stopper providing a fluid tight seal for a distal end of the barrel, a motor for displacing the plunger connected to the stopper, wherein the front-end device is attachable to the back-end device, wherein the needle shroud is slidably arranged with respect to the injection needle and wherein an interlock switch is capable of detecting an axial position (PA, PR) of the needle shroud.

Claims

1. An auto-injector (A) for administering a dose of a liquid medicament, comprising:

a tubular front-end device configured to contain a syringe with an injection needle and a barrel containing the dose of the medicament and comprising a needle shroud configured to rest on skin of a patient receiving an injection; and

a reusable back-end device comprising;

a housing,

a plunger configured to engage a stopper providing a fluid tight seal for a distal end of the barrel,

a motor for displacing the plunger connected to the stopper, wherein the back-end device further comprises an encoder sensor to determine the position of the plunger, wherein the encoder sensor is positioned inside the back-end device,

a gearbox connected to the motor and to the plunger, the gearbox to receive a torque provided by the motor and to transfer the torque to the plunger, wherein the gearbox comprises;

a worm gear attached to the motor, wherein the worm gear receives the torque provided by the motor and rotates in response to receiving the torque in a direction perpendicular to a longitudinal axis of the auto-injector, and

a plurality of gear teeth, wherein a first gear tooth of the plurality of gear teeth is connected to the worm gear, wherein the plurality of gear teeth are configured to receive a rotation of the worm gear and to rotate in a direction parallel to the longitudinal axis of the auto-injector,

wherein the front-end device is attachable to the back-end device, wherein the needle shroud is slidably arranged with respect to the injection needle and wherein an interlock switch is configured to detect an axial position of the needle shroud.

2. The auto-injector (A) according to claim 1, wherein the needle shroud comprises an extension arm that is configured to interact with the interlock switch so as to communicate the axial position of the needle shroud to the back-end device of the auto-injector (A).

3. The auto-injector (A) according to claim 1, wherein the back-end device comprises a sensor unit configured to detect actual parameters of the injection, a memory unit configured to store user related data or specification parameters and a visual, acoustical or haptic feedback provider to the user of the auto-injector (A).

4. The auto-injector (A) according to claim 3, wherein the sensor unit is arranged to measure a current through the motor during needle insertion, wherein the back-end is arranged to compare the measured current to a specified current and to abort the injection when the measured current is out of specification.

5. The auto-injector (A) according to claim 3, wherein the back-end is arranged to detect an initial position of the stopper by the sensor unit and compare it to a specified initial position, wherein the back-end device is arranged to abort the injection when the measured position is more proximal than specified.

6. The auto-injector (A) according to claim 3, wherein the back-end device is arranged to detect a stall of the motor by measuring the current or processing data from the sensor unit and to release or retract the plunger when having detected the stall.

7. The auto-injector (A) according to claim 1, wherein the back-end device is arranged to start an injection cycle when detecting the needle shroud in a retracted position (PR).

8. The auto-injector (A) according to claim 7, wherein the back-end device is arranged to sense the presence of a syringe in the front-end device and to start the injection cycle only when the syringe is present.

9. The auto-injector (A) according to claim 1, wherein the back-end device is arranged to release or to retract the plunger when detecting the needle shroud in an advanced position (PR) after having started the injection cycle.

10. The auto-injector (A) according to claim 1, wherein the back-end device is arranged to detect the position of the stopper by the encoder sensor during an injection cycle in order to adapt the speed of the plunger to different phases of the injection cycle, needle insertion, drug delivery and retraction.

11. The auto-injector (A) according to claim 1, wherein the encoder sensor is arranged as a slotted encoder wheel driven by the motor and arranged between an emitter and a sensor of an optical coupler.

12. The auto-injector (A) of claim 1, further comprising a rack and pinion gear pair, the rack attached to the plunger, the pinion attached to the plurality of teeth, wherein the rack and pinion gear pair is configured to convert a rotation of the plurality of gear teeth into a translation of the plunger along the longitudinal axis.

13. An auto-injector comprising:

a substantially tubular front-end device; and

a reusable back-end device attachable to the front-end device, the back-end device comprising;

a housing,

a plunger,

a motor for displacing the plunger,

an encoder sensor to determine the position of the plunger,

a gearbox connected to the motor and to the plunger, the gearbox to receive a torque provided by the motor and to transfer the torque to the plunger, wherein the gearbox comprises;

a worm gear attached to the motor, wherein the worm gear receives the torque provided by the motor and rotates in response to receiving the torque in a direction perpendicular to a longitudinal axis of the auto-injector, and

a plurality of gear teeth, wherein a first gear tooth of the plurality of gear teeth is connected to the worm gear, wherein the plurality of gear teeth are configured to receive a rotation of the worm gear and to rotate in a direction parallel to the longitudinal axis of the auto-injector.