Fluid delivery manifolds and microfluidic systems

• US 9,579,649 B2
• Filed: 10/07/2010
• Issued: 02/28/2017
• Est. Priority Date: 10/07/2010
• Status: Active Grant

• Current Assignee: National Technology & Engineering Solutions Of Sandia LLC (Honeywell International Inc.)
• Original Assignee: Sandia Corporation (Martin Marietta Corporation)
• Inventors: Van de Vreugde, James L., Renzi, Ronald F., Sommer, Gregory J., Singh, Anup K., Hatch, Anson V., Claudnic, Mark R., Wang, Ying-Chih
• Primary Examiner(s): Alexander, Lyle
• Assistant Examiner(s): EOM, ROBERT J
• Application Number:
  US12/900,276
• Publication Number:
  US 20120085644A1
• Time in Patent Office: 2,336 Days
• Field of Search: 422500-507
• US Class Current: 1/1
• CPC Class Codes: B01L 2200/025 Align devices or objects to ensure defined positions relative to each other
• CPC Class Codes: B01L 2200/027 for microfluidic devices
• CPC Class Codes: B01L 2200/04 Exchange or ejection of cartridges, containers or reservoirs
• CPC Class Codes: B01L 2200/0689 Sealing
• CPC Class Codes: B01L 2300/0645 Electrodes
• CPC Class Codes: B01L 2300/0816 Cards, e.g. flat sample carriers usually with flow in two horizontal directions
• CPC Class Codes: B01L 2300/0858 Side walls
• CPC Class Codes: B01L 2400/0421 electrophoretic flow
• CPC Class Codes: B01L 2400/0487 fluid pressure, pneumatics
• CPC Class Codes: B01L 3/502715 characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
• CPC Class Codes: B01L 3/56 Labware specially adapted for transferring fluids
• CPC Class Codes: G01N 2035/00158 Elements containing microarrays, i.e. "biochip"
• CPC Class Codes: G01N 27/44743 Introducing samples
• CPC Class Codes: G01N 27/44791 Microapparatus sample containers with integrated microfluidic structures B01L3/5027
• CPC Class Codes: G01N 35/1095 for supplying the samples to flow-through analysers for a specific analyser see relevant groups, e.g. under G01N15/00, G01N21/00, G01N27/00, G01N30/00, H01J49/00
• CPC Class Codes: Y10T 137/6851 With casing, support, protector or static constructional installations

Abstract

Embodiments of fluid distribution manifolds, cartridges, and microfluidic systems are described herein. Fluid distribution manifolds may include an insert member and a manifold base and may define a substantially closed channel within the manifold when the insert member is press-fit into the base. Cartridges described herein may allow for simultaneous electrical and fluidic interconnection with an electrical multiplex board and may be held in place using magnetic attraction.

Claims

1. A fluid distribution manifold comprising:

an insert member comprising a first surface, a second surface opposite the first surface, and a sidewall extending between the first surface and the second surface, wherein the insert member at least partially defines at least one channel on the first surface, wherein the at least one channel is configured for fluid communication between an inlet location and a plurality of outlet locations provided on the first surface, and wherein the at least one channel is open along a length of the at least one channel between the inlet location and at least one of the plurality of outlet locations;

a manifold base comprising a first surface and a second surface opposite the first surface, wherein the manifold base at least partially defines an indentation in the first surface, the indentation comprising a recessed surface and a sidewall, the indentation having a shape configured to receive the insert member such that the insert member fills the indentation and the insert member is attached to the manifold base by friction between respective sidewalls of the insert member and the indentation; and

wherein at least one of the manifold base and the insert member at least partially defines a fluid inlet in fluid communication with the inlet location, and wherein at least one of the manifold base and the insert member at least partially defines a plurality of fluid outlets, wherein ones of the fluid outlets are in fluid communication with respective ones of the plurality of outlet locations.

2. The fluid distribution manifold of claim 1, wherein a first portion of the recessed surface forms a wall of the at least one channel when a second portion of the recessed surface of the indentation adjacent to the first portion is in contact with the first surface of the insert member to form a substantially closed channel that provides a fluid-tight seal between the insert member and the manifold base.

3. The fluid distribution manifold of claim 1, wherein the insert member at least partially defines the fluid inlet from the second surface of the insert member to the inlet location.

4. The fluid distribution manifold of claim 1, wherein the manifold base at least partially defines the fluid inlet from the second surface of the manifold base to the inlet location.

5. The fluid distribution manifold of claim 1, wherein the insert member at least partially defines at least one of the fluid outlets from the second surface of the insert member to at least one of the outlet locations.

6. The fluid distribution manifold of claim 1, wherein the manifold base at least partially defines at least one of the fluid outlets from the second surface of the manifold base to at least one of the outlet locations.

7. The fluid distribution manifold of claim 1, wherein a size of the insert member is slightly larger than a size of the indentation of the manifold base, wherein the indentation is configured to deform to accommodate the insert member by press-fitting.

8. The fluid distribution manifold of claim 1, wherein the fluid inlet is configured to receive a fluid from an external source.

9. The fluid distribution manifold of claim 1, wherein individual of the plurality of outlets are configured to provide a fluid from the inlet to respective locations of a microfluidic chip.

10. The fluid distribution manifold of claim 1, wherein the at least one channel has a width of less than 500 microns.

11. The fluid distribution manifold of claim 1, wherein the at least one channel has a width of less than 200 microns.

12. The fluid distribution manifold of claim 1, wherein the fluid communication comprises a route from the inlet location to the plurality of outlet locations.

13. The fluid distribution manifold of claim 1, wherein the fluid inlet and fluid outlets extend from the first surface of the insert member to the second surface of the insert member.

14. The fluid distribution manifold of claim 1, wherein the fluid inlet and fluid outlets extend from the second surface of the insert member to the second surface of the manifold base.

15. The fluid distribution manifold of claim 1, wherein the insert member further comprising a raised portion on the first surface and wherein the channel is defined in the raised portion, and wherein the indentation is a primary indentation, the manifold base further comprising a secondary indentation in the primary indentation, the secondary indentation configured for insertion of the raised portion therein.