Methods and devices for sample lysis
First Claim
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1. A microfluidic chip comprising:
- a. a chamber which comprises at least one stir bar or a plurality of granular particles;
b. a thermal device in thermal contact with the chamber; and
c. at least one insulative groove within the surface of the chip, wherein the at least one insulative groove is configured such that during operation of the chip, ambient air enters the at least one insulative groove and insulates the chamber, and wherein the at least one insulative groove is a plurality of grooves positioned around the chamber.
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Abstract
Disclosed herein are methods and systems for use in preparing a sample. The methods and systems may be used for lysing one or more structures in a sample (e.g., cells, viral particles, etc.). The methods and compositions may comprise a microfluidic chip or use thereof. The microfluidic chips disclosed herein may comprise (a) a substrate comprising a chamber, wherein at least one mechanical element may be located within the chamber; (b) a thermal element in contact with the chamber; and (c) at least one aperture within the surface of the substrate, wherein the aperture may be configured to insulate the chamber.
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Citations
24 Claims
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1. A microfluidic chip comprising:
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a. a chamber which comprises at least one stir bar or a plurality of granular particles; b. a thermal device in thermal contact with the chamber; and c. at least one insulative groove within the surface of the chip, wherein the at least one insulative groove is configured such that during operation of the chip, ambient air enters the at least one insulative groove and insulates the chamber, and wherein the at least one insulative groove is a plurality of grooves positioned around the chamber. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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Specification