Micro-sensor based test apparatus

• US 9,581,593 B2
• Filed: 02/15/2013
• Issued: 02/28/2017
• Est. Priority Date: 02/16/2012
• Status: Active Grant

• Current Assignee: Microvisk Ltd.
• Original Assignee: Microvisk Ltd.
• Inventors: Ibbotson, Robert, Djakov, Vladislav, Dunn, Richard
• Primary Examiner(s): WHITE, DENNIS MICHAEL
• Application Number:
  US14/379,170
• Publication Number:
  US 20150017067A1
• Time in Patent Office: 1,474 Days
• US Class Current: 1/1
• CPC Class Codes: G01N 33/54373 involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
• CPC Class Codes: G01N 33/86 involving blood coagulating time or factors, or their receptors

Abstract

There is provided a fluid test strip, comprising a micro-sensor formed on a substrate surface and a reagent deposition site formed on the substrate surface, operate to control the size and location of a reagent deposition. There is also provided a method of forming fluid test strip, comprising forming a micro-sensor on a substrate surface and forming a reagent deposition site on the substrate surface, operable to control the size and location of a reagent deposition.

Claims

1. A fluid test strip, comprising:

a micro-sensor formed on a substrate surface, wherein the micro-sensor comprises a micro-cantilever; and

a reagent deposition site formed on the substrate surface, operable to control the size and location of a reagent deposition;

wherein the deposition site comprises a central island portion, annularly surrounded by a portion of non-existent surface material; and

wherein the reagent deposition site is formed adjacent the micro-sensor.

2. The fluid test strip of claim 1, wherein the reagent deposition site is formed in a predetermined shape beneficial to the operation of the micro-sensor.

3. The fluid test strip of claim 2, wherein the predetermined shape comprises a shape operable to encompass at least a portion of the micro sensor.

4. The fluid test strip of claim 2, wherein the predetermined shape comprises a portion encompassing a sensitive end of the micro-cantilever.

5. The fluid test strip of claim 1, wherein a portion of non-existent surface material comprises a moat.

6. The fluid test strip of claim 1, further comprising at least one fence, wherein a fence comprises a portion of the surface material annular surrounding a portion of non-existent surface material.

7. The fluid test strip of claim 6, wherein the at least one fence comprises multiple moats and fences, each numbered in the range of 1 to 3.

8. The fluid test strip of claim 1, wherein the at last one moat comprises between one and three moats and the at least one fence comprises between one and three fences.

9. The fluid test strip of claim 1, wherein the micro-sensor is operable to detect changes in a fluid under test as a result of a reaction between the fluid under test and one or more reagents deposited in the deposition site.

10. The fluid test strip of claim 1, wherein the reagent deposition site comprises a fixed area.

11. The fluid test strip of claim 10, wherein any moats and/or fences comprises up to 40% of the total deposition area.

12. The fluid test strip of claim 1, wherein the deposition site is formed dependent upon one or more of:

a contact angle of the surface material;

a volume of deposited reagent fluid;

a hydrophilicity of the surface material;

a hydrophobicity of the surface material;

a surface energy of the surface material;

a surface treatment of the surface material.

13. The fluid test strip of claim 1, further comprising multiple deposition sites within the vicinity of one or more micro-sensors.

14. A method of forming fluid test strip, comprising:

forming a micro-sensor on a substrate surface, wherein the micro-sensor comprises a micro-cantilever; and

forming a reagent deposition site on the substrate surface, operable to control the size and location of a reagent deposition;

wherein forming the reagent deposition site further comprises forming the deposition site to have a central island portion, annularly surrounded by a portion of non-existent surface material; and

the method further comprising forming the reagent deposition site adjacent the micro-sensor.

15. The method of claim 14, further comprising forming the reagent deposition site in a predetermined shape beneficial to the response of the micro-sensor to the specific test.

16. The method of claim 14, wherein the predetermined shape comprises a shape operable to encompass at least a portion of the micro-sensor.

17. The method of claim 14, wherein the predetermined shape comprises a portion encompassing a sensitive end of the micro-cantilever.

18. The method of claim 14, wherein a portion of non-existent surface material comprises a moat.

19. A computer-readable medium comprising instructions, which, when executed by a processor connected to a test strip manufacturing apparatus, cause the apparatus to carry out the method of claim 14.