Synergistically acting ternary antimicrobial mixtures

• US 9,585,388 B2
• Filed: 11/05/2012
• Issued: 03/07/2017
• Est. Priority Date: 11/04/2011
• Status: Active Grant

• Current Assignee: Symrise AG
• Original Assignee: Symrise AG
• Inventors: Pillai, Ravikumar, Khler, Antje, Schmaus, Gerhard
• Primary Examiner(s): Wax, Robert A
• Assistant Examiner(s): Singh, Randeep
• Application Number:
  US13/668,560
• Publication Number:
  US 20130136709A1
• Time in Patent Office: 1,583 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 31/02 Acyclic compounds
• CPC Class Codes: A01N 31/14 Ethers
• CPC Class Codes: A23L 3/3481 Organic compounds containing oxygen
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 2800/524 Preservatives
• CPC Class Codes: A61K 2800/5922 At least two compounds being classified in the same subclass of A61K8/18
• CPC Class Codes: A61K 31/047 having two or more hydroxy groups, e.g. sorbitol
• CPC Class Codes: A61K 31/085 having an ether linkage to aromatic ring nuclear carbon
• CPC Class Codes: A61K 8/34 Alcohols
• CPC Class Codes: A61K 8/345 containing more than one hydroxy group
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/10 Anti-acne agents
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 31/10 Antimycotics
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61Q 1/02 Preparations containing skin colorants, e.g. pigments preparations in powder form A61Q1/12
• CPC Class Codes: A61Q 15/00 Anti-perspirants or body deodorants deodorisation of air A61L9/00
• CPC Class Codes: A61Q 17/005 : Antimicrobial preparations
• CPC Class Codes: A61Q 17/04 : Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
• CPC Class Codes: A61Q 19/00 : Preparations for care of the skin
• CPC Class Codes: A61Q 5/02 : Preparations for cleaning the hair

Abstract

The invention relates to synergistically effective ternary antimicrobial mixtures.

Claims

1. A cosmetic or pharmaceutical preparation or foodstuff comprising an antimicrobially effective mixture, wherein the antimicrobially effective mixture consists of:

(a) 2-phenoxyethanol,

(b1) 1,2-decanediol, and

(b2) 1,2-hexanediol and/or 1,2-pentanediol and/or 1,2-octanediol.

2. The cosmetic or pharmaceutical preparation or foodstuff according to claim 1, wherein the antimicrobially effective mixture consists of:

(a) 2-phenoxyethanol,

(b1) 1,2-decanediol, and

(b2) 1,2-hexanediol and/or 1,2-pentanediol.

3. The cosmetic or pharmaceutical preparation or foodstuff according to claim 1, wherein the total amount of the antimicrobially effective mixture is in the range from 0.01 to 10 wt %, relative to the total mass of the preparation or of the foodstuff.

4. The cosmetic or pharmaceutical preparation or foodstuff according to claim 2 comprising:

0.30 to 1.20 wt % of 2-phenoxyethanol,

0.05 to 0.40 wt % of 1,2-decanediol, and

0.01 to 0.30 wt % of the total amount of 1,2-hexanediol and/or 1,2-pentanediol, in each case relative to the total mass of the preparation or of the foodstuff.