Devices and methods for noninvasive measurement of intracranial pressure
First Claim
Patent Images
1. A system for measuring intracranial pressure, comprising:
- a pressure sensor;
an optical imager;
an ophthalmic component, comprising;
a deformable material;
an osculating surface configured to contact a subject'"'"'s cornea, sclera, eyelid, or any combination thereof;
the deformable material and osculating surface partially defining a closed control volume enclosed within the ophthalmic component wherein the closed control volume is configured to retain a pressure within when in contact with a subject'"'"'s cornea, sclera, eyelid, or any combination thereof;
a passage placing the control volume in fluid communication with the pressure sensor so as to sense a pressure within the control volume;
at least a portion of the osculating surface and a portion of the ophthalmic component opposite the osculating surface being configured to permit sufficient passage of light therethrough so as to allow optical imaging of a blood vessel within a subject'"'"'s eye contacting the osculating surface;
a pressurizing unit in fluid communication with the control volume, the pressurizing unit being configured to increase a pressure within the control volume to exert the osculating surface toward the subject'"'"'s cornea, sclera, eyelid, or any combination thereof; and
a processor operatively connected to the pressure sensor, the optical imager, and the pressurizing unit and configured to controllably pressurize the control volume with the pressurizing unit and estimate an intracranial pressure of a subject based on images of an intraocular blood vessel of the subject'"'"'s eye through the ophthalmic component from the optical imager.
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Accused Products
Abstract
Provided are systems and methods for noninvasively assessing intracranial pressure by controllably osculating at least a portion of a subject'"'"'s ocular globe while applying a force sufficient to collapse an intraocular blood vessel and correlating the collapse pressure to intracranial pressure. Also provided are ophthalmic components useful in ophthalmic imaging applications, such as retinal, corneal, and pupil imaging. The components may include an optical contact surface that has a radius of curvature that is greater than the radius of curvature of a subject'"'"'s cornea.
32 Citations
18 Claims
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1. A system for measuring intracranial pressure, comprising:
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a pressure sensor; an optical imager; an ophthalmic component, comprising; a deformable material; an osculating surface configured to contact a subject'"'"'s cornea, sclera, eyelid, or any combination thereof; the deformable material and osculating surface partially defining a closed control volume enclosed within the ophthalmic component wherein the closed control volume is configured to retain a pressure within when in contact with a subject'"'"'s cornea, sclera, eyelid, or any combination thereof; a passage placing the control volume in fluid communication with the pressure sensor so as to sense a pressure within the control volume; at least a portion of the osculating surface and a portion of the ophthalmic component opposite the osculating surface being configured to permit sufficient passage of light therethrough so as to allow optical imaging of a blood vessel within a subject'"'"'s eye contacting the osculating surface; a pressurizing unit in fluid communication with the control volume, the pressurizing unit being configured to increase a pressure within the control volume to exert the osculating surface toward the subject'"'"'s cornea, sclera, eyelid, or any combination thereof; and a processor operatively connected to the pressure sensor, the optical imager, and the pressurizing unit and configured to controllably pressurize the control volume with the pressurizing unit and estimate an intracranial pressure of a subject based on images of an intraocular blood vessel of the subject'"'"'s eye through the ophthalmic component from the optical imager. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method of estimating a pressure in a subject, comprising:
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with an ophthalmic component comprising; a deformable material and an osculating surface; the osculating surface being configured to contact a subject'"'"'s cornea, sclera, eyelid, or any combination thereof; the osculating surface partially defining a closed control volume enclosed within the ophthalmic component; the control volume configured to retain a pressure within when in contact with a subject'"'"'s cornea, sclera, eyelid, or any combination thereof; the ophthalmic component further comprising a passage placing the control volume in fluid communication with a pressure sensor configured to sense a pressure within the control volume; and at least a portion of the osculating surface and a portion of the ophthalmic component opposite the osculating surface being configured to permit sufficient passage of light therethrough so as to allow optical imaging of a blood vessel within a subject'"'"'s eye contacting the osculating surface; applying a force to the subject'"'"'s cornea, sclera, eyelid, or any combination thereof with the osculating surface while the osculating surface contacts a portion of the subject'"'"'s cornea, sclera, eyelid, or any combination thereof; the force being sufficient to collapse an intraocular blood vessel of the subject; and correlating the force that collapses the intraocular blood vessel to an estimated intracranial pressure of the subject. - View Dependent Claims (12, 13, 14, 15, 16)
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17. An ophthalmic component, comprising:
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a deformable material and an osculating surface, the osculating surface being configured to contact a subject'"'"'s cornea, sclera, eyelid, or any combination thereof, the osculating surface partially defining a closed control volume enclosed within the ophthalmic component, the control volume configured to retain a pressure within when in contact with a subject'"'"'s cornea, sclera, eyelid, or any combination thereof, the ophthalmic component further comprising a passage placing the control volume in fluid communication with a pressure sensor configured to sense a pressure within the control volume, and at least a portion of the osculating surface and a portion of the ophthalmic component opposite the osculating surface being configured to permit sufficient passage of light therethrough so as to allow optical imaging of a blood vessel within a subject'"'"'s eye contacting the osculating surface. - View Dependent Claims (18)
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Specification