Multiplexed pathlength resolved noninvasive analyzer apparatus with dynamic optical paths and method of use thereof
First Claim
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1. A method for noninvasively determining an analyte concentration of a person, comprising the steps of:
- providing a near-infrared analyzer, comprising;
at least one near-infrared source;
a detector; and
a photon transport system configured to direct photons from said source to said detector via an analyzer-sample optical interface;
dynamically changing, within a time window of data collection for a single analyte concentration determination, a mean radial illumination position of incident light from said near-infrared source relative to a center of said analyzer-sample optical interface; and
using a piezoelectrically positioned mirror to change a mean incident radial light path, relative to the center of said analyzer-sample optical interface, into the skin by at least twenty-five percent.
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Abstract
A noninvasive analyzer apparatus and method of use thereof is described comprising a near-infrared source, a detector, and a photon transport system configured to direct photons from the source to the detector via an analyzer-sample optical interface. The photon transport system includes a dynamically position light directing unit used to, within a measurement time period for a single analyte concentration determination, change any of: radius, energy, intensity, position, incident angle, solid angle, and/or depth of penetration of a beam of photons entering skin of a subject.
165 Citations
16 Claims
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1. A method for noninvasively determining an analyte concentration of a person, comprising the steps of:
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providing a near-infrared analyzer, comprising; at least one near-infrared source; a detector; and a photon transport system configured to direct photons from said source to said detector via an analyzer-sample optical interface; dynamically changing, within a time window of data collection for a single analyte concentration determination, a mean radial illumination position of incident light from said near-infrared source relative to a center of said analyzer-sample optical interface; and using a piezoelectrically positioned mirror to change a mean incident radial light path, relative to the center of said analyzer-sample optical interface, into the skin by at least twenty-five percent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. An apparatus for noninvasively determining an analyte concentration of a person, comprising:
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a near-infrared analyzer, comprising; at least one near-infrared source; a detector; and a photon transport system configured to direct photons from said source to said detector via an analyzer-sample optical interface, said photon transport system further comprising; means for dynamically changing, within a time period of data collection for a single analyte concentration determination, a radial illumination position of incident light from said near-infrared source relative to a center of said analyzer-sample optical interface, said means for dynamically changing the radial illumination position comprising a dynamically positioned optic system, said means for dynamically changing the radial position of the incident light, comprising; a piezoelectrically controlled optic, said piezoelectrically controlled optic configured to change an effective depth of focus of the incident light by at least ten percent for said single analyte concentration determination. - View Dependent Claims (14, 15, 16)
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Specification