Device and methods for treating paranasal sinus conditions

• US 9,585,681 B2
• Filed: 09/15/2010
• Issued: 03/07/2017
• Est. Priority Date: 04/04/2005
• Status: Active Grant

• Current Assignee: Intersect ENT, Inc. (Medtronic Plc)
• Original Assignee: Intersect ENT, Inc. (Medtronic Plc)
• Inventors: Eaton, Donald J., Tice, Thomas R., Downie, David B., Arensdorf, Patrick A., Brenneman, Rodney A., Biggs, Danielle L.
• Primary Examiner(s): MEDWAY, SCOTT J
• Application Number:
  US12/883,087
• Publication Number:
  US 20110004192A1
• Time in Patent Office: 2,365 Days
• Field of Search: 604/101.01, 604/94.01, 604/514, 606/199
• US Class Current: 1/1
• CPC Class Codes: A61B 17/24 for use in the oral cavity, larynx, bronchial passages or nose for medical inspection of cavities or tubes in the body A61B1/00; Tongue scrapers
• CPC Class Codes: A61F 2/186 Nose parts
• CPC Class Codes: A61K 31/573 substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
• CPC Class Codes: A61K 31/58 containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin digitoxin A61K31/7048
• CPC Class Codes: A61K 47/14 Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
• CPC Class Codes: A61K 47/34 Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers A61K47/10 takes precedence
• CPC Class Codes: A61K 9/0043 Nose
• CPC Class Codes: A61K 9/1647 Polyesters, e.g. poly(lactide-co-glycolide)
• CPC Class Codes: A61K 9/70 Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug hollow drug-filled fibres A61K9/0092
• CPC Class Codes: A61M 29/00 Dilators with or without means for introducing media, e.g. remedies instruments for performing visual medical inspections of cavities or tubes of the body A61B1/00
• CPC Class Codes: A61P 27/16 Otologicals
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 37/00 Drugs for immunological or allergic disorders
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Described here are paranasal sinus devices for treating paranasal sinus conditions. The devices include a cavity member, ostial member, and nasal portion. One or more of the cavity member, ostial member, and nasal portion may deliver an active agent for sustained release to treat the paranasal sinus condition. Exemplary paranasal sinus conditions are sinus inflammation due to functional endoscopic sinus surgery (FESS) and rhinosinusitis.

Claims

1. A method of delivering a paranasal sinus device comprising:

advancing a bioabsorbable expandable device into a paranasal sinus cavity with a delivery device, the expandable device being sized and shaped to fit within a paranasal sinus cavity and being at least partly conformable to the shape thereof, the expandable device comprising a pronged structure comprising a plurality of filaments that expand radially outwardly, each filament having a proximal end and a distal end, wherein only the proximal ends of each filament join together, and wherein the distal end of each filament is a free distal end; and

withdrawing the delivery device, wherein the expandable device remains in and at least partially conformed to the paranasal sinus cavity after the delivery device has been completely withdrawn.

2. The method of claim 1 wherein the expandable device is configured to biodegrade.

3. The method of claim 2 wherein the expandable device comprises one or more biodegradable polymers.

4. The method of claim 1 wherein the expandable device is configured to release one or more active agents.

5. The method of claim 1 wherein the one or more active agents comprises mometasone furoate.

6. The method of claim 1 wherein the expandable device comprises one or more radiopaque markers.

7. The method of claim 6 further comprising indirectly visualizing the expandable device.

8. The method of claim 1 wherein advancing the expandable device comprises advancing the expandable device under direct visualization.

9. The method of claim 1 wherein the expandable device is self-expanding.

10. The method of claim 1 wherein the expandable device comprises one or more anchoring elements on each filament, wherein the anchoring elements are configured to anchor the expandable device within the paranasal sinus cavity.

11. The method of claim 1 wherein each filament is between about 2 cm and about 5 cm in length.

12. The method of claim 1 wherein the delivery device comprises a handle, a sheath, and a distal portion onto which the expandable device is loaded.