Treatment of skin, including aging skin, to improve appearance

• US 9,585,817 B2
• Filed: 06/09/2016
• Issued: 03/07/2017
• Est. Priority Date: 03/13/2013
• Status: Active Grant

• Current Assignee: Transdermal Biotechnology, Inc.
• Original Assignee: Transdermal Biotechnology, Inc.
• Inventors: Perricone, Nicholas V.
• Primary Examiner(s): Maewall, Snigdha
• Application Number:
  US15/177,562
• Publication Number:
  US 20160279038A1
• Time in Patent Office: 271 Days
• US Class Current: 1/1
• CPC Class Codes: A61K 2800/596 Mixtures of surface active compounds
• CPC Class Codes: A61K 2800/78 Enzyme modulators, e.g. Enzyme agonists
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61K 38/066 TRH, thyroliberin, thyrotropin releasing hormone
• CPC Class Codes: A61K 8/0216 Solid or semisolid forms
• CPC Class Codes: A61K 8/0295 Liquid crystals
• CPC Class Codes: A61K 8/14 Liposomes; Vesicles
• CPC Class Codes: A61K 8/19 containing inorganic ingredients
• CPC Class Codes: A61K 8/553 Phospholipids, e.g. lecithin
• CPC Class Codes: A61K 8/64 Proteins; Peptides; Derivatives or degradation products thereof
• CPC Class Codes: A61Q 19/004 Aftersun preparations
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations

Abstract

The present invention generally relates to compositions and methods for transdermal delivery, treatment of skin, and improving the appearance of skin. In some cases, the composition may include nitric oxide and/or peptides. The nitric oxide and/or peptide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other vesicles containing nitric oxide, peptides, or both. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like.

Claims

1. A method of improving skin appearance, comprising:

administering, to the skin of a subject, a composition comprising an effective amount of thyrotropin-releasing hormone (TRH) and molecular nitric oxide to improve skin appearance, and a carrier comprising lecithin entrapping the molecular nitric oxide, wherein the composition is stable at room temperature.

2. The method of claim 1, wherein the carrier further comprises polyenylphosphatidylcholine.

3. The method of claim 1, wherein the composition comprises a liquid crystal structure.

4. The method of claim 1, wherein the composition comprises no more than about 250 ppm of water by weight of the composition.

5. The method of claim 1, wherein the lecithin is present at at least about 0.25% by weight of the composition.

6. The method of claim 1, wherein the molecular nitric oxide is present at at least about 0.5% by weight of the composition without nitric oxide.

7. The method of claim 1, wherein the molecular nitric oxide is present within the composition as a gas.

8. The method of claim 1, wherein the molecular nitric oxide is bound by hydrogen bonds or van der Waals forces to the lecithin.

9. The method of claim 1, wherein the composition is a cream.

10. The method of claim 1, wherein the skin of the subject is aging skin.

11. The method of claim 1, wherein the skin of the subject is wrinkled.

12. The method of claim 1, wherein the skin has been damaged due to exposure to ultraviolet light.

13. The method of claim 1, wherein the skin is sunburned skin.

14. A method of improving skin appearance, comprising:

administering, to the skin of a subject, a composition comprising an effective amount of thyrotropin-releasing hormone (TRH) and molecular nitric oxide to improve skin appearance, and a carrier entrapping lecithin containing the molecular nitric oxide, wherein the first phase comprises no more than about 250 ppm of water by weight of the composition.

15. The method of claim 14, wherein the carrier further comprises polyenylphosphatidylcholine.

16. The method of claim 14, wherein the composition comprises a liquid crystal structure.

17. The method of claim 14, wherein the composition is stable at room temperature.

18. The method of claim 14, wherein the lecithin is present at at least about 0.25% by weight of the composition.

19. The method of claim 14, wherein the molecular nitric oxide is present at at least about 0.5% by weight of the composition without nitric oxide.

20. The method of claim 14, wherein the molecular nitric oxide is present within the composition as a gas.

21. The method of claim 14, wherein the molecular nitric oxide is bound by hydrogen bonds or van der Waals forces to the lecithin.

22. The method of claim 14, wherein the composition is a cream.