Use of nitrated lipids for treatment of side effects of toxic medical therapies

• US 9,585,855 B2
• Filed: 03/11/2014
• Issued: 03/07/2017
• Est. Priority Date: 06/19/2008
• Status: Active Grant

• Current Assignee: University of Utah Research Foundation (State of Utah)
• Original Assignee: University of Utah Research Foundation (State of Utah)
• Inventors: Yang, Tianxin
• Primary Examiner(s): Heyer, Dennis
• Application Number:
  US14/205,108
• Publication Number:
  US 20140256815A1
• Time in Patent Office: 1,092 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61K 31/201 having one or two double bonds, e.g. oleic, linoleic acids
• CPC Class Codes: A61P 13/00 Drugs for disorders of the urinary system
• CPC Class Codes: A61P 13/12 of the kidneys
• CPC Class Codes: A61P 39/00 General protective or antinoxious agents

Abstract

The present invention relates to methods of treating the side effects of a toxic medical therapy using nitrated lipids. In particular, the methods comprise the use of nitrated fatty acids or esters thereof to treat side effects, including organ system damage, caused by chemotherapy, radiotherapy, and the administration of other toxic agents.

Claims

1. A method of treating renal system damage in a subject comprising administering to the subject an effective amount of a nitrated fatty acid;

wherein the renal system damage is selected from a group consisting of nephrotoxicity, distortion of the overall renal morphology, dilation of renal tubules, appearance of protein cast, oxidative stress, necrosis, and apoptosis of organ cells.

2. The method of claim 1, wherein the nitrated fatty acid is a monounsaturated fatty acid or a polyunsaturated fatty acid.

3. The method of claim 1, wherein the nitrated fatty acid is nitro-oleic-acid.

4. The method of claim 1, wherein the nitrated fatty acid is selected from the group consisting of 9-nitrooleic acid, 10-nitrooleic acid, and combinations thereof.

5. The method of claim 1, wherein the effective amount is from about 1 milligram per day to about 500 milligrams per day.