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Polynucleotides encoding anti-amyloid beta monoclonal antibodies

  • US 9,585,956 B2
  • Filed: 09/22/2015
  • Issued: 03/07/2017
  • Est. Priority Date: 06/12/2007
  • Status: Active Grant
First Claim
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1. An isolated polynucleotide encoding an antibody or fragment thereof that binds to beta-amyloid, wherein said antibody or fragment thereof comprises:

  • (a) a light chain variable region (VL) complementarity determining region (CDR) 1 comprising the amino acid sequence of SEQ ID NO;

    11;

    (b) a VL CDR2 comprising the amino acid sequence of SEQ ID NO;

    12;

    (c) a VL CDR3 comprising the amino acid sequence of SEQ ID NO;

    13;

    (d) a heavy chain variable region (VH) CDR1 comprising the amino acid sequence of SEQ ID NO;

    14;

    (e) a VH CDR2 comprising the amino acid sequence of SEQ ID NO;

    15; and

    (f) a VH CDR3 comprising the amino acid sequence of SEQ ID NO;

    16.

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