×

Method for increasing the permeability of an epithelial barrier

  • US 9,586,044 B2
  • Filed: 04/27/2011
  • Issued: 03/07/2017
  • Est. Priority Date: 04/28/2010
  • Status: Active Grant
First Claim
Patent Images

1. A method for increasing the permeability of a cellular layer that comprises epithelial cells, the method comprising:

  • contacting the cellular layer with a microneedle, the microneedle including a plurality of nanostructures and microstructures formed on an external surface thereof in a predetermined pattern, wherein at least a portion of the microstructures have a cross-sectional dimension of greater than about 500 nanometers and less than about 10 micrometers and a height of from about 20 nanometers to about 1 micrometer, the cross-sectional dimension of the microstructures being greater than the height of the microstructures, wherein at least a portion of the nanostructures having a cross-sectional dimension of from about 5 nanometers to about 500 nanometers, wherein subsequent to contact between the cellular layer and the microneedle, the cellular layer exhibits increased permeability to the drug compound.

View all claims
  • 9 Assignments
Timeline View
Assignment View
    ×
    ×