Mixing of fluids in fluidic systems
First Claim
1. A method, comprising:
- flowing in a channel a series of fluid plugs comprising a first fluid plug comprising a first fluid, a second fluid plug comprising a second fluid, and a third fluid plug comprising a third fluid, wherein the first fluid plug has a first volume,wherein the second fluid plug is positioned between the first and third fluid plugs, andwherein the second fluid is immiscible with each of the first and third fluids, the method comprising;
while the first fluid plug is flowing, depositing at least a portion of the first fluid on a wall of the channel for combining with the third fluid plug;
reducing the first volume of the first fluid plug by at least 50%; and
combining at least a portion of the first fluid into the third fluid plug so as to mix at least portions of the first and third fluids, andafter the combining step, flowing in the channel the first fluid plug, the second fluid plug, and the third fluid plug which comprises the third fluid and at least a portion of the first fluid.
1 Assignment
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Accused Products
Abstract
Fluidic devices and methods associated with mixing of fluids in fluidic devices are provided. In some embodiments, a method may involve the mixing of two or more fluids in a channel segment of a fluidic device. The fluids may be in the form of, for example, at least first, second and third fluid plugs, composed of first, second, and third fluids, respectively. The second fluid may be immiscible with the first and third fluids. In certain embodiments, the fluid plugs may be flowed in series in the channel segment, e.g., in linear order, causing the first and third fluids to mix without the use of active to components such as mixers. The mixing of fluids in a channel segment as described herein may allow for improved performance and simplification in the design and operations of fluidic devices that rely on mixing of fluids.
169 Citations
26 Claims
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1. A method, comprising:
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flowing in a channel a series of fluid plugs comprising a first fluid plug comprising a first fluid, a second fluid plug comprising a second fluid, and a third fluid plug comprising a third fluid, wherein the first fluid plug has a first volume, wherein the second fluid plug is positioned between the first and third fluid plugs, and wherein the second fluid is immiscible with each of the first and third fluids, the method comprising; while the first fluid plug is flowing, depositing at least a portion of the first fluid on a wall of the channel for combining with the third fluid plug; reducing the first volume of the first fluid plug by at least 50%; and combining at least a portion of the first fluid into the third fluid plug so as to mix at least portions of the first and third fluids, and after the combining step, flowing in the channel the first fluid plug, the second fluid plug, and the third fluid plug which comprises the third fluid and at least a portion of the first fluid. - View Dependent Claims (4, 5, 6, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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2. A method, comprising:
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flowing in series in a channel a first fluid plug comprising a first fluid, a second fluid plug comprising a second fluid, and a third fluid plug comprising a third fluid, wherein the second fluid is immiscible with each of the first and third fluids, wherein the second fluid plug is positioned between the first and third fluid plugs, and wherein the first fluid comprises a first component for a chemical and/or biological reaction and the third fluid comprises a second component for a chemical and/or biological reaction, and wherein the first component is different from the second component; and while the first fluid plug is flowing, depositing at least a portion of the first fluid on a wall of the channel for combining with the third fluid plug; and combining at least a portion of the first fluid deposited on the wall of the channel into the third fluid plug so as to mix at least portions of the first and third fluids, and after the combining step, flowing in the channel the first fluid plug, the second fluid plug, and the third fluid plug which comprises the third fluid and at least a portion of the first fluid.
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3. A method, comprising:
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flowing in series in a channel a first fluid plug comprising a first fluid, a second fluid plug comprising a second fluid, and a third fluid plug comprising a third fluid, wherein the first fluid comprises a first component for a chemical and/or biological reaction and the third fluid comprises a second component for a chemical and/or biological reaction, wherein the second fluid is immiscible with the first and third fluids, and wherein the second fluid plug is positioned between the first and third fluid plugs; and while the first fluid plug is flowing, depositing at least a portion of the first fluid on a wall of the channel for combining with the third fluid plug, and combining at least a portion of the first fluid into the third fluid plug so as to mix at least portions of the first and third fluids, and after the combining step, flowing in the channel the first fluid plug, the second fluid plug, and the third fluid plug which comprises the third fluid and at least a portion of the first fluid; and performing one or more chemical and/or biological reactions involving each of the first and second components. - View Dependent Claims (7)
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Specification