Method and system to derive multiple glycemic patterns from glucose measurements during time of the day
First Claim
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1. A system for management of diabetes of a subject, the system comprising:
- at least one glucose monitor that is configured to measure a glucose concentration based on an enzymatic reaction with physiological fluid in a biosensor that provides an electrical signal representative of the glucose concentration; and
a controller in communication with the at least one glucose monitor, the controller being configured to receive or transmit glucose data representative of glucose levels measured by the glucose monitor over a predetermined time period and to determine whether the glucose data includes or does not include;
(a) an overall trend of the glucose data, the overall trend having;
(1) a minimum number of glucose measurements;
(2) a minimum number of glucose measurements that have values in an above a target range, below a target range, or in-range category in a time slot; and
(3) a percentage of glucose measurements in the timeslot being greater than a minimum threshold;
(b) a minor trend of the glucose data, the minor trend having a minimum number of glucose measurements within a specified number of days that have values above a target range, below a target range, or in-range category in the time slot and all of the glucose measurements in the minimum number must be within a specified number of hours of each other; and
(c) a significant trend of the glucose data, the significant trend having;
(1) a minimum number of glucose measurements;
(2) a chi-squared test confidence level greater than a threshold; and
the controller, upon determination of the glucose data including both of the overall trend and minor trend but not the significant trend, annunciating to the subject such determination and using both of the determined overall trend and minor trend to calculate an amount of a drug to be delivered to the subject; and
a drug delivery device in communication with the controller, the drug delivery device being configured to deliver the calculated amount of the drug to the subject.
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Abstract
Described are methods and systems for determining modal patterns from an overall trend, minor trend or significant trend for various periods during a time of the day modal report which can be utilized to provide insights to the person with diabetes.
7 Citations
19 Claims
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1. A system for management of diabetes of a subject, the system comprising:
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at least one glucose monitor that is configured to measure a glucose concentration based on an enzymatic reaction with physiological fluid in a biosensor that provides an electrical signal representative of the glucose concentration; and a controller in communication with the at least one glucose monitor, the controller being configured to receive or transmit glucose data representative of glucose levels measured by the glucose monitor over a predetermined time period and to determine whether the glucose data includes or does not include; (a) an overall trend of the glucose data, the overall trend having; (1) a minimum number of glucose measurements; (2) a minimum number of glucose measurements that have values in an above a target range, below a target range, or in-range category in a time slot; and (3) a percentage of glucose measurements in the timeslot being greater than a minimum threshold; (b) a minor trend of the glucose data, the minor trend having a minimum number of glucose measurements within a specified number of days that have values above a target range, below a target range, or in-range category in the time slot and all of the glucose measurements in the minimum number must be within a specified number of hours of each other; and (c) a significant trend of the glucose data, the significant trend having; (1) a minimum number of glucose measurements; (2) a chi-squared test confidence level greater than a threshold; and the controller, upon determination of the glucose data including both of the overall trend and minor trend but not the significant trend, annunciating to the subject such determination and using both of the determined overall trend and minor trend to calculate an amount of a drug to be delivered to the subject; and a drug delivery device in communication with the controller, the drug delivery device being configured to deliver the calculated amount of the drug to the subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method of managing diabetes risks of a subject, the method comprising:
determining at least one of certain trends in a time of a day for glucose measurements with at least one glucose monitor and a controller in communication with the at least one glucose monitor, the controller including a microprocessor and configured to receive or transmit glucose data representative of glucose levels measured by the glucose monitor, and the determining comprising; performing a plurality of glucose measurements over a predetermined time period with the glucose monitor; identifying, with the microprocessor, from the plurality of glucose measurements whether the glucose data includes or does not include; (a) an overall trend of the glucose data, the overall trend having; (1) a minimum number of glucose measurements; (2) a minimum number of glucose measurements that have values in the above a target range, below a target range, or in-range category in the time slot; and (3) a percentage of glucose measurements in the timeslot being greater than a minimum threshold; (b) a significant trend in which such significant trend is statistically and significantly different than the trends observed in other timeslots and a chi-squared test is used to determine if a particular time slot of the time slots is statistically significantly different than other time slots;
the statistical test being based on a percentage of hypoglycemic incidence per the time slot interval and a predicted percentage of hypoglycemic incidence per the time slot interval; and(c) a minor trend of the glucose data, the minor trend having a minimum number of glucose measurements within a specified number of days that have values above a target range, below a target range, or in-range category in the time slot and all of the glucose measurements in the minimum number must be within a specified number of hours of each other in the event the identifying step indicates the glucose data includes both of the overall trend and the minor trend but not the significant trend; using at least one of the overall trend or the minor trend to calculate an amount of a drug to be delivered to the subject by a drug delivery device in communication with the controller, wherein the amount of the drug is calculated to manage diabetes risks of the subject; and delivering, by the drug delivery device, the calculated amount of the drug to the subject. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19)
Specification