Devices and methods for minimally invasive reduction of parathyroid adenomas

• US 9,592,018 B2
• Filed: 02/11/2014
• Issued: 03/14/2017
• Est. Priority Date: 02/19/2013
• Status: Active Grant

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Robertson, David W.
• Primary Examiner(s): FOWLER, DANIEL WAYNE
• Application Number:
  US14/178,101
• Publication Number:
  US 20140236145A1
• Time in Patent Office: 1,127 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 18/1477 Needle-like probes
• CPC Class Codes: A61B 2017/00079 Radioactivity
• CPC Class Codes: A61B 2018/00702 Power or energy
• CPC Class Codes: A61B 6/4057 by using radiation sources located in the interior of the body A61B6/037 takes precedence
• CPC Class Codes: A61B 6/425 using detectors specially adapted to be used in the interior of the body
• CPC Class Codes: A61B 6/4258 for detecting non x-ray radiation, e.g. gamma radiation A61B6/037 takes precedence

Abstract

Apparatus and methods for performing glandular reduction are described. In an example embodiment, an apparatus includes a needle-like probe containing a scintillation detector for converting gamma and x-rays emitted from a radio-labeled gland into photons that are then carried from the probe through a fiberoptic cable to a photodetector, and a therapy element for causing selective tissue destruction by directing energy toward the radio-labeled gland.

Claims

1. A method of glandular reduction in a patient, comprising:

marking a gland as a target tissue with a material that emits energy;

inserting a probe into the patient and the target tissue, wherein inserting the probe includes;

measuring energy emitted from the marked target tissue using a detector within the probe,

positioning the probe in proximity to the target tissue based upon the measured energy, and

guiding the probe to the target tissue by rotating and longitudinally translating a shield surrounding the detector, wherein the shield blocks the energy, the rotating and longitudinal translating of the shield takes place within the probe, and the shield has an aperture for allowing the energy to reach the detector; and

delivering therapy energy from a therapy element of the probe to the target tissue.

2. The method of claim 1 wherein the detector is a scintillation detector, and the method further comprises conveying photons from the scintillation detector to a photodetector via a fiber optic cable.

3. The method of claim 1 further comprising delivering the therapy energy from the therapy element in a manner to cause necrosis of the target tissue.

4. The method of claim 1 further comprising:

(a) rotating the aperture until the measured energy is at a maximum, wherein the aperture is rotated within the probe;

(b) adjusting an insertion angle of the probe toward the direction that the aperture faces; and

,

(c) rotating the aperture while the energy is measured, wherein the aperture is rotated within the probe, and repeating steps (a) and (b) until no change in the measured energy is detected and a central longitudinal axis of the probe extends toward the target tissue.

5. The method of claim 4 further comprising, after the insertion angle of the probe is adjusted so that the central longitudinal axis of the probe extends toward the target tissue:

(a) increasing the insertion depth of the aperture by moving the aperture longitudinally within the probe toward the target tissue;

(b) measuring the energy from the target tissue and, if an increase in the measured energy is detected after increasing the insertion depth of the aperture, increasing the insertion depth of the probe; and

,

(c) repeating steps (a) and (b) until no increase in the measured energy is detected at step (b) and then initiating delivery of the therapy energy from the probe.

6. The method of claim 5 wherein the positioning of the probe is performed by a robotic manipulator.

7. The method of claim 5 wherein the rotation and translation of the shield is performed by a robotic manipulator.

8. The method of claim 1 wherein the target tissue is a parathyroid adenoma.

9. The method of claim 1 wherein delivering the therapy energy to the target tissue includes delivering, to the target tissue from a voltage source, one of radio-frequency electrical energy and direct current electrical energy.

10. The method of claim 1 wherein the therapy element is an ultrasonic transducer.

11. The method of claim 1 wherein marking the gland includes radio-labeling the gland such that radiation is emitted from the radio-labeled gland.

12. An apparatus, comprising:

a probe for inserting into a body tissue containing a target tissue marked with a material that emits energy;

a detector within the probe;

a therapy element incorporated into the probe for delivering therapy energy to the target tissue;

a control unit that includes a therapy element actuator and processing circuitry connected to a photodetector;

wherein the processing circuitry is configured to measure the energy emitted from the marked target tissue from signals generated by the photodetector;

wherein the therapy element actuator is operable to cause delivery of the therapy energy by the therapy element to the target tissue; and

a shield surrounding the detector to block the energy, wherein the shield is within the probe, the shield has an aperture for allowing the energy to reach the detector, and the shield is rotatable and longitudinally translatable within the probe to facilitate positioning of the probe in proximity to the target tissue.

13. The apparatus of claim 12 wherein the shield is rotatable and longitudinally translatable along a longitudinal axis of the probe to facilitate positioning of the probe in proximity to the target tissue.

14. The apparatus of claim 13 further comprising a robotic manipulator operated by the processing circuitry, wherein the processing circuitry is programmed to:

(a) rotate the aperture until the energy measured is at a maximum, wherein the aperture is rotated within the probe;

(b) adjust an insertion angle of the probe toward the direction that the aperture faces; and

,

(c) rotate the aperture while the energy is measured, wherein the aperture is rotated within the probe, and repeat steps (a) and (b) until no change in the measured energy is detected and a central longitudinal axis of the probe extends toward the target tissue.

15. The apparatus of claim 14 wherein, after the insertion angle of the probe is adjusted so that the probe points toward the target tissue, the processing circuitry is programmed to:

(a) increase the insertion depth of the aperture by moving the aperture longitudinally within the probe toward the target tissue;

(b) measure the energy from the target tissue and, if an increase in measured energy is detected after increasing the insertion depth of the aperture, increase the insertion depth of the probe; and

,

(c) repeat steps (a) and (b) until no increase in the measured energy is detected at step (b) and then initiate delivery of the therapy energy from the probe.

16. The apparatus of claim 12 wherein the therapy element is operatively coupled to a voltage source for delivering at least one of radio-frequency electrical energy and direct current electrical energy to the target tissue.

17. The apparatus of claim 12 wherein the therapy element is an ultrasonic transducer.

18. The apparatus of claim 12 further comprising a user interface connected to the processing circuitry for at least one of providing information to an operator relating to the energy measurement, and for controlling the therapy element actuator.

19. The apparatus of claim 12 wherein the therapy element includes at least two electrodes, and the detector and the aperture are located between the electrodes.

20. An apparatus, comprising:

a probe for inserting into a body tissue containing a target tissue marked with a material that emits energy, wherein the probe has a closed distalmost end;

a detector within the probe;

a therapy element incorporated into the probe for delivering therapy energy to the target tissue; and

a shield surrounding the detector to block the energy, wherein the shield is within the probe, the shield has an aperture for allowing the energy to reach the detector, and the shield and the aperture are rotatable and longitudinally translatable within the probe to facilitate positioning of the probe in proximity to the target tissue.