Apparatus and method for tissue adhesion

• US 9,592,040 B2
• Filed: 05/19/2016
• Issued: 03/14/2017
• Est. Priority Date: 09/20/2008
• Status: Active Grant

• Current Assignee: Microkoll, Inc
• Original Assignee: Micokoll Inc.
• Inventors: Anderson, Steven Craig
• Primary Examiner(s): MILES, JONATHAN WADE
• Application Number:
  US15/159,617
• Publication Number:
  US 20160324512A1
• Time in Patent Office: 299 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 17/0057 Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect sutures A61B17/04; closing rectum or urethra near body surface A61F2/0009
• CPC Class Codes: A61B 17/064 Surgical staples, i.e. penetrating the tissue
• CPC Class Codes: A61B 17/0644 penetrating the tissue, deformable to closed position
• CPC Class Codes: A61B 17/08 Wound clamps or clips, i.e. not or only partly penetrating the tissue suture bridges A61B17/0466; Devices for bringing together the edges of a wound
• CPC Class Codes: A61B 17/11 for performing anastomosis; Buttons for anastomosis
• CPC Class Codes: A61B 17/12113 within an aneurysm
• CPC Class Codes: A61B 17/12118 for positioning in conjunction with a stent
• CPC Class Codes: A61B 17/12131 characterised by the type of occluding device
• CPC Class Codes: A61B 17/12136 Balloons
• CPC Class Codes: A61B 17/12145 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 2017/00579 Barbed implements
• CPC Class Codes: A61B 2017/00632 Occluding a cavity, i.e. closing a blind opening
• CPC Class Codes: A61B 2017/00668 the implement being a tack or a staple
• CPC Class Codes: A61B 2017/00862 elastic or resilient for sutures A61B2017/0618
• CPC Class Codes: A61B 2017/00867 shape memory effect for prostheses A61F2210/0014
• CPC Class Codes: A61B 2017/00951 adhesive
• CPC Class Codes: A61B 2017/0641 having at least three legs as part of one single body
• CPC Class Codes: A61B 2017/0647 having one single leg, e.g. tacks
• CPC Class Codes: A61B 2017/0649 Coils or spirals
• CPC Class Codes: A61B 2017/1107 for blood vessels
• CPC Class Codes: A61B 2017/1132 : End-to-end connections
• CPC Class Codes: A61B 2017/12063 : electrolytically detachable
• CPC Class Codes: A61B 2017/12072 : the heat created by laser light
• CPC Class Codes: A61B 2017/1209 : detachable by electrical current or potential, e.g. electroactive polymer
• CPC Class Codes: A61F 2/0063 : Implantable repair or support meshes, e.g. hernia meshes
• CPC Class Codes: A61F 2/848 : having means for fixation to the vessel wall, e.g. barbs
• CPC Class Codes: A61F 2002/0081 : directly machined on the prosthetic surface, e.g. holes, grooves A61F2/30771 takes precedence
• CPC Class Codes: A61F 2002/8483 : Barbs
• CPC Class Codes: A61F 2013/00357 : implanted wound fillings or covers membranes for covering bone defects A61F2/2846
• CPC Class Codes: A61F 2210/0014 : using shape memory or superelastic materials, e.g. nitinol
• CPC Class Codes: A61F 2220/0016 : with sharp anchoring protrusions, e.g. barbs, pins, spikes

Abstract

An array of a plurality of shape memory material microposts have a proximal end configured to be secured to a substrate with a tissue penetrating distal end. The microposts further have a deployment state with the microposts in a substantially straightened configuration with a substantially smooth and continuous outer surface which is substantially parallel to adjacent microposts and an engaged state wherein at least a section of the microposts assume a configuration that is not substantially parallel to adjacent microposts or is not substantially straight with a substantially smooth and continuous outer surface so as to mechanically capture tissue adjacent thereto.

Claims

1. A method for treating an aneurism, comprising:

providing an elastically expandable balloon substrate having a contact surface;

forming an array of microposts extending from the contact surface of the balloon substrate, said microposts fabricated from a shape memory material and having a proximal end secured to the substrate, and a sharpened tissue penetrating distal end;

elastically expanding the balloon substrate by inflation thereby deploying the microposts into the tissue of the aneurism, the microposts being disposed in a substantially straightened configuration, being substantially perpendicular to the substrate, and being substantially parallel to adjacent microposts;

engaging the microposts by activation of the shape memory material after penetration into the tissue of the aneurism wherein a distal section of each micropost mechanically captures tissue adjacent thereto and said microposts are no longer substantially parallel to adjacent microposts and no longer in a straightened configuration;

deflating the balloon substrate thereby causing closure of the balloon substrate and tissue of the aneurism.

2. The method of claim 1 further comprising sealing the deflated balloon substrate upon itself via self-adhering internal surfaces.

3. The method of claim 2 wherein sealing the deflated balloon substrate upon itself via self-adhering internal surfaces comprises utilizing mating Velcro sheets to seal the deflated balloon substrate upon itself.

4. The method of claim 2 wherein sealing the deflated balloon substrate upon itself via self-adhering internal surfaces comprises utilizing an adhesive to seal the deflated balloon substrate upon itself.

5. The method of claim 1 wherein the microposts are fabricated from alloy shape memory material.

6. The method of claim 1 wherein the microposts are fabricated from shape memory polymer material.

7. The method of claim 1 wherein activation of the shape memory material after penetration into the tissue of the aneurism comprises thermal activation of the shape memory material.

8. The method of claim 1 wherein activation of the shape memory material after penetration into the tissue of the aneurism comprises photonic activation of the shape memory material.

9. The method of claim 1 wherein activation of the shape memory material after penetration into the tissue of the aneurism comprises Ph change activation of the shape memory material.

10. The method of claim 1 wherein activation of the shape memory material after penetration into the tissue of the aneurism comprises electrical activation of the shape memory material.

11. The method of claim 1 wherein the balloon substrate is fabricated from an elastic polymer.

12. The method of claim 11 wherein the elastic polymer comprises silicone.

13. The method of claim 11 wherein the elastic polymer comprises polyurethane.

14. The method of claim 11 wherein the elastic polymer comprises latex rubber.