Apparatus and method for measuring concentration of hemoglobin using photothermal effect
First Claim
1. An apparatus for measuring concentration of hemoglobin in blood using a photothermal effect, the apparatus comprising:
- a reference light source radiating a reference beam;
a photothermal light source radiating a photothermal beam from which the photothermal effect is generated;
a cuvette accommodating a collected blood sample thereinto and having first and second reflection layers; and
a concentration operator loaded on and executed by a hardware processor and calculating the concentration of hemoglobin by using the phase changes of interference signals generated from the incidence of the reference beam radiated from the reference light source onto the first and second reflection layers of the cuvette unit as the photothermal beam radiated from the photothermal light source is incident onto the cuvette and absorbed by hemoglobin to generate the photothermal effect through the emission of heat,wherein the concentration operator reads the reflected interference signals through a spectrometer, reads absolute values of complex numbers obtained through inverse Fourier transform of the interference signals, finds the path-length having the greatest absolute value, and obtains the phase in the signal of the path-length.
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Abstract
The present invention relates to an apparatus for measuring concentration of hemoglobin in blood using a photothermal effect, the apparatus including: a reference light source unit for radiating a reference beam; a photothermal light source unit for radiating a photothermal beam from which the photothermal effect is generated; a cuvette unit for accommodating a collected blood sample thereinto and having first and second reflection layers; and a concentration operation unit for calculating the concentration of hemoglobin by using the phase changes of interference signals generated from the incidence of the reference beam radiated from the reference light source unit onto the first and second reflection layers of the cuvette unit as the photothermal beam radiated from the photothermal light source unit is incident onto the cuvette unit and absorbed by hemoglobin to generate the photothermal effect through the emission of heat.
13 Citations
14 Claims
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1. An apparatus for measuring concentration of hemoglobin in blood using a photothermal effect, the apparatus comprising:
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a reference light source radiating a reference beam; a photothermal light source radiating a photothermal beam from which the photothermal effect is generated; a cuvette accommodating a collected blood sample thereinto and having first and second reflection layers; and a concentration operator loaded on and executed by a hardware processor and calculating the concentration of hemoglobin by using the phase changes of interference signals generated from the incidence of the reference beam radiated from the reference light source onto the first and second reflection layers of the cuvette unit as the photothermal beam radiated from the photothermal light source is incident onto the cuvette and absorbed by hemoglobin to generate the photothermal effect through the emission of heat, wherein the concentration operator reads the reflected interference signals through a spectrometer, reads absolute values of complex numbers obtained through inverse Fourier transform of the interference signals, finds the path-length having the greatest absolute value, and obtains the phase in the signal of the path-length. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method for measuring concentration of hemoglobin using a hemoglobin concentration measuring apparatus, the apparatus comprising a reference light source radiating a reference beam, a photothermal light source radiating a photothermal beam from which the photothermal effect is generated, a cuvette accommodating a collected blood sample thereinto and having first and second reflection layers, and a concentration operator for calculating the concentration of hemoglobin by using the phase changes of interference signals generated from the incidence of the reference beam radiated from the reference light source onto the first and second reflection layers of the cuvette as the photothermal beam radiated from the photothermal light source is incident onto the cuvette and absorbed by hemoglobin to generate the photothermal effect through the emission of heat, the method comprising the steps of:
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providing the blood sample to the cuvette; allowing the reference light source to radiate the reference beam; allowing the reference beam radiated from the reference light source unit to be incident onto the cuvette and reflected onto the first and second reflection layers of the cuvette and detecting the phases of the interference signals generated from the reflection of the reference beam; allowing the photothermal light source to radiate the photothermal beam;
allowing the photothermal beam radiated from the photothermal light source to be incident onto the cuvette and to be absorbed by hemoglobin to generate the photothermal effect through the emission of heat;allowing the reference beam radiated from the reference light source to be incident onto the cuvette and reflected onto the first and second reflection layers of the cuvette and detecting the phases changes of the interference signals generated from the reflection of the reference beam; and operating the hemoglobin concentration in accordance with the relationship between the phase changes of the interference signals and the hemoglobin concentration, wherein the concentration operator reads the reflected interference signals through a spectrometer, reads absolute values of complex numbers obtained through inverse Fourier transform of the interference signals, finds the path-length having the greatest absolute value, and obtains the phase in the signal of the path-length.
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Specification