Biological signal measuring system and biological signal measuring apparatus

• US 9,597,025 B2
• Filed: 05/23/2014
• Issued: 03/21/2017
• Est. Priority Date: 06/13/2013
• Status: Active Grant

• Current Assignee: Nihon Kohden Corporation
• Original Assignee: Nihon Kohden Corporation
• Inventors: Kobayashi, Naoki, Hirabara, Hideaki
• Primary Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US14/286,426
• Publication Number:
  US 20140371557A1
• Time in Patent Office: 1,033 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 2505/01 Emergency care
• CPC Class Codes: A61B 2505/03 Intensive care
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: A61B 5/6826 Finger
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal
• CPC Class Codes: A61B 5/7271 Specific aspects of physiological measurement analysis A61B5/316, A61B5/349 and A61B5/374 take precedence
• CPC Class Codes: G01N 2021/3144 for oxymetry
• CPC Class Codes: G01N 2021/3148 using three or more wavelengths
• CPC Class Codes: G01N 21/314 with comparison of measurements at specific and non-specific wavelengths dual wavelength spectrometry G01J3/427

Abstract

A biological signal measuring system includes: a light emitter emitting light beams having different N kinds of wavelengths, where N is an integer of four or more; a light receiver outputting N kinds of signals respectively in accordance with received light intensities of the N kinds of light beams that have been passed through or reflected from a living tissue; a first calculating section acquiring N kinds of light attenuations based on the N kinds of signals; a second calculating section acquiring (N−1) kinds of blood-derived light attenuations based on two light attenuations related to (N−1) kinds of combinations selected from the N kinds of light attenuations; a third calculating section identifying concentrations of (N−1) kinds of in-blood substances based on the (N−1) kinds of blood-derived light attenuations; and an outputting section outputting the identified concentrations.

Claims

1. A biological signal measuring system comprising:

a light emitter which is configured to emit light beams to a living tissue of a subject, the light beams having different N kinds of wavelengths, where N is an integer of four or more;

a light receiver which is configured to output N kinds of signals respectively in accordance with received light intensities of the N kinds of light beams that have been passed through or reflected from the living tissue of the subject;

a first calculating section which is configured to acquire N kinds of light attenuations based on the N kinds of signals;

a second calculating section which is configured to acquire (N−

1) kinds of blood-derived light attenuations based on two light attenuations related to (N−

1) kinds of combinations selected from the N kinds of light attenuations;

a third calculating section which is configured to identify concentrations of (N−

1) kinds of in-blood substances based on the (N−

1) kinds of blood-derived light attenuations; and

an outputting section which is configured to output the identified concentrations,

wherein the light attenuations are acquired based on changes of the received light intensities of a first timing during pressurization in which a pressure is applied to the living tissue and of a second timing before the pressurization or after release of the pressurization, wherein the pressure substantially eliminates both arterial and venous blood from the living tissue.

2. The biological signal measuring system according to claim 1, wherein the second calculating section acquires each of the blood-derived light attenuations based on a difference of the two light attenuations.

3. The biological signal measuring system according to claim 2, wherein two wavelengths corresponding to the two light attenuations which are used for acquiring the difference are selected as wavelengths in which a difference of light attenuations of non-blood tissue is smaller, from the N kinds of wavelengths.

4. The biological signal measuring system according to claim 2, wherein the difference is obtained by multiplying by a coefficient corresponding to the light attenuation of nonblood tissue in the corresponding wavelength.

5. The biological signal measuring system according to claim 1, wherein the N is four, and the in-blood substances are three kinds selected from oxygenated hemoglobin, reduced hemoglobin, carbon monoxide hemoglobin, and methemoglobin.

6. The biological signal measuring system according to claim 1, wherein the N is five, and the in-blood substances are oxygenated hemoglobin, reduced hemoglobin, carbon monoxide hemoglobin, and methemoglobin.

7. The biological signal measuring system according to claim 1, further comprising a monitoring section which is configured to cause the third calculating section to identify the concentrations at a predetermined timing.

8. The biological signal measuring system according to claim 7, wherein the monitoring section notifies a timing when the living tissue is to be pressed, through the outputting section.

9. The biological signal measuring system according to claim 7, further comprising:

a pressurizing section which is adapted to be attached to the subject so as to pressurize the living tissue; and

a pressurization controlling section which is configured to control the pressurizing section for causing changes of light attenuations of the living tissue.

10. The biological signal measuring system according to claim 1, further comprising a pressure detecting section which is configured to detect the pressure applied to the living tissue, and which is configured to output a signal corresponding to the pressure.

11. The biological signal measuring system according to claim 1, wherein

the pressure is applied to the living tissue located between the light emitter and the light receiver.

12. A biological signal measuring apparatus comprising:

a signal receiving section which is configured to receive N kinds of signals corresponding to light intensities of light beams that have been passed through or reflected from a living tissue of a subject and that have N kinds of wavelengths, where N is an integer of four or more;

a first calculating section which is configured to acquire N kinds of light attenuations based on the N kinds of signals;

a second calculating section which is configured to acquire (N−

1) kinds of blood-derived light attenuations based on two light attenuations related to (N−

1) kinds of combinations selected from the N kinds of light attenuations;

a third calculating section which is configured to identify concentrations of (N−

1) kinds of in-blood substances based on the (N−

1) kinds of blood-derived light attenuations; and

an outputting section which is configured to output the identified concentrations, wherein the light attenuations are acquired based on changes of the received light intensities of a first timing during pressurization in which a pressure is applied to the living tissue and of a second timing before the pressurization or after release of the pressurization, and

wherein the pressure substantially eliminates both arterial and venous blood from the living tissue.

13. The biological signal measuring apparatus according to claim 12, wherein

the pressure is applied to the living tissue located between a light emitter configured to emit the light beams and a light receiver configured to output the N kinds of signals.

14. A method of controlling a biological signal measuring apparatus comprising a signal receiving section which is configured to receive N kinds of signals corresponding to light intensities of light beams that have been passed through or reflected from a living tissue of a subject and that have N kinds of wavelengths, where N is an integer of four or more, the method comprising:

acquiring N kinds of light attenuations based on the N kinds of signals;

acquiring (N−

1) kinds of blood-derived light attenuations based on two light attenuations related to (N−

1) kinds of combinations selected from the N kinds of light attenuations;

identifying concentrations of (N−

1) kinds of in-blood substances based on the (N−

1) kinds of blood-derived light attenuations, and

outputting the identified concentrations,

wherein the light attenuations are acquired based on changes of the received light intensities of a first timing during pressurization in which a pressure is applied to the living tissue and of a second timing before the pressurization or after release of the pressurization, and

wherein the pressure substantially eliminates both arterial and venous blood from the living tissue.

15. A non-transitory computer-readable storage medium storing a program causing a computer to execute the method according to claim 14.

16. The method according to claim 14, wherein

the pressure is applied to the living tissue located between a light emitter configured to emit the light beams and a light receiver configured to output the N kinds of signals.