Locating a neural prosthesis using impedance and electrode height

• US 9,597,495 B2
• Filed: 04/20/2012
• Issued: 03/21/2017
• Est. Priority Date: 06/08/2004
• Status: Expired due to Fees

• Current Assignee: Doheny Eye Institute, Second Sight Medical Products, Inc.
• Original Assignee: Second Sight Medical Products, Inc.
• Inventors: Greenberg, Robert J., Fine, Jone, Roy, Arup, McMahon, Matthew J., Humayun, Mark S., Welland, James David, Horsager, Alan M., Zhou, Dao Min, Hines, Amy, Yadav, Sumit, Dai, Rongqing
• Primary Examiner(s): Koharski, Christopher D
• Assistant Examiner(s): KIMBALL, JEREMIAH T
• Application Number:
  US13/452,300
• Publication Number:
  US 20120203293A1
• Time in Patent Office: 1,796 Days
• Field of Search: 607/54
• US Class Current: 1/1
• CPC Class Codes: A61N 1/0543 Retinal electrodes
• CPC Class Codes: A61N 1/36046 of the eye
• CPC Class Codes: A61N 1/37247 User interfaces, e.g. input or presentation means

Abstract

The invention is a method of identifying a preferred location for an electrode array to the neural characteristics of an individual subject. The response to electrical neural stimulation varies from subject to subject and array location to array location. Measure of impedance may be used to predict the electrode height from the neural tissue and, thereby, predict the preferred location. Alternatively, electrode height may be measured directly to predict the preferred location.

Claims

1. A method of determining proper placement of a neural stimulation electrode array comprising:

placing an electrode array of an implantable neural prosthesis in proximity of neural tissue;

sending a series of wireless command signals under automatic control to the implantable neural prosthesis to measure impedances, and thereby threshold of perception, across the electrode array after providing sub-threshold of perception stimulation pulses to neural tissue on each electrode;

communicating the impedances to a clinician via a wireless telemetry signal;

determining, by the impedances, the distance between the electrode array and neural tissue, as well as any defective electrodes;

selecting a proper chronic placement for the electrode array as the location providing the least distance between the electrode array and neural tissue, the lowest threshold of perception and the greatest dynamic range;

attaching the electrode array chronically to neural tissue in the proper chronic placement; and

stimulating neural percepts with the electrode array.

2. The method according to claim 1, further comprising:

placing the electrode array in a plurality of locations;

measuring impedance across the electrode array in each location; and

determining, by the impedances, the best placement of the electrode array.

3. The method according to claim 1, further comprising:

communicating the impedance to an external device; and

displaying the impedance to a user on the external device.

4. The method according to claim 3, wherein displaying the impedance to a user is displaying the impedance to a user with a graphical representation of the plurality of electrodes.

5. The method according to claim 3, wherein displaying the impedance to a user is by sound.

6. The method according to claim 3, wherein displaying the impedance to a user is by color.

7. The method according to claim 3, wherein displaying the impedance to a user is by graphical symbol.