Arginine methyltransferase inhibitors and uses thereof

• US 9,598,374 B2
• Filed: 03/14/2014
• Issued: 03/21/2017
• Est. Priority Date: 03/14/2013
• Status: Active Grant

• Current Assignee: Epizyme, Inc. (Ipsen Sa)
• Original Assignee: Epizyme, Inc. (Ipsen Sa)
• Inventors: Swinger, Kerren Kalai, Chesworth, Richard, Mitchell, Lorna Helen, Shapiro, Gideon
• Primary Examiner(s): SHTERENGARTS, SAMANTHA L
• Application Number:
  US14/775,794
• Publication Number:
  US 20160024016A1
• Time in Patent Office: 1,103 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61K 31/415 1,2-Diazoles
• CPC Class Codes: A61K 31/4155 non condensed and containing further heterocyclic rings
• CPC Class Codes: A61P 21/00 Drugs for disorders of the muscular or neuromuscular system
• CPC Class Codes: A61P 21/04 for myasthenia gravis
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 3/00 Drugs for disorders of the metabolism of the blood or the extracellular fluid A61P7/00
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 37/00 Drugs for immunological or allergic disorders
• CPC Class Codes: A61P 37/02 Immunomodulators
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: C07D 231/12 with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
• CPC Class Codes: C07D 401/04 directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07D 403/04 directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07D 403/08 linked by a carbon chain containing alicyclic rings
• CPC Class Codes: C07D 405/04 directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07D 405/08 linked by a carbon chain containing alicyclic rings
• CPC Class Codes: C07D 405/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 493/10 Spiro-condensed systems

Abstract

Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein are useful for inhibiting arginine methyltransferase activity. Methods of using the compounds for treating arginine methyltransferase-mediated disorders are also described.

Claims

1. A compound of formula:

2. The compound of claim 1, wherein the compound is:

3. The compound of claim 1, wherein the compound is a pharmaceutically acceptable salt of:

4. A pharmaceutical composition comprising a compound of claim 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

5. A pharmaceutical composition comprising a compound of claim 2, and a pharmaceutically acceptable excipient.

6. A pharmaceutical composition comprising a compound of claim 3, and a pharmaceutically acceptable excipient.

7. A kit or packaged pharmaceutical comprising a compound of claim 1, or a pharmaceutically acceptable salt thereof, and instructions for use thereof.

8. A kit or packaged pharmaceutical comprising a compound of claim 2, and instructions for use thereof.

9. A kit or packaged pharmaceutical comprising a compound of claim 3, and instructions for use thereof.