Particles coated with zwitterionic polymers comprising sulfobetaine or carboxybetaine
First Claim
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1. A surface having a layer of sulfobetaine polymers coupled thereto, wherein the density of the sulfobetaine polymers in the layer provides a surface having a fibrinogen adsorption of less than about 30 ng/cm2 in a fibrinogen binding assay when the surface is incubated at 37°
- C. for 90 minutes with a 1.0 mg/mL fibrinogen solution (0.15 M phosphate buffered saline at pH 7.4).
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Abstract
Nanoparticles zwitterionic polymers grafted thereto or grafted therefrom, and methods for making and using the nanoparticles. Zwitterionic nanogels, and methods for making and using the nanogels.
37 Citations
19 Claims
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1. A surface having a layer of sulfobetaine polymers coupled thereto, wherein the density of the sulfobetaine polymers in the layer provides a surface having a fibrinogen adsorption of less than about 30 ng/cm2 in a fibrinogen binding assay when the surface is incubated at 37°
- C. for 90 minutes with a 1.0 mg/mL fibrinogen solution (0.15 M phosphate buffered saline at pH 7.4).
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A substrate comprising a surface having a layer of sulfobetaine polymers grafted from the surface, wherein the density of the sulfobetaine polymers in the layer provides a surface having a fibrinogen adsorption of less than about 30 ng/cm2 in a fibrinogen binding assay when the surface is incubated at 37°
- C. for 90 minutes with a 1.0 mg/mL fibrinogen solution (0.15 M phosphate buffered saline at pH 7.4).
- View Dependent Claims (13, 14, 15, 16, 17, 18, 19)
Specification