Neuroplasticity games for depression

• US 9,601,026 B1
• Filed: 03/07/2014
• Issued: 03/21/2017
• Est. Priority Date: 03/07/2013
• Status: Active Grant

• Current Assignee: Posit Science Corp.
• Original Assignee: Posit Science Corp.
• Inventors: Merzenich, Michael M., Luk, Chung-Hay, Nahum, Mor, Van Vleet, Thomas Matthew
• Primary Examiner(s): Rowland, Steve
• Application Number:
  US14/201,689
• Time in Patent Office: 1,110 Days
• US Class Current: 1/1
• CPC Class Codes: A63F 13/47 involving branching, e.g. choosing one of several possible scenarios at a given point in time
• CPC Class Codes: A63F 13/537 using indicators, e.g. showing the condition of a game character on screen
• CPC Class Codes: A63F 13/67 adaptively or by learning from player actions, e.g. skill level adjustment or by storing successful combat sequences for re-use
• CPC Class Codes: A63F 13/80 Special adaptations for executing a specific game genre or game mode
• CPC Class Codes: G09B 19/00 Teaching not covered by other main groups of this subclass teaching or practice apparatus for gun-aiming or gun-laying F41G3/26
• CPC Class Codes: G09B 5/00 Electrically-operated educational appliances working with questions and answers G09B7/00; simulators G09B9/00; advertising or displaying in general G09F
• CPC Class Codes: G09B 5/02 with visual presentation of the material to be studied, e.g. using film strip
• CPC Class Codes: G09B 5/06 with both visual and audible presentation of the material to be studied
• CPC Class Codes: G09B 5/065 Combinations of audio and video presentations, e.g. videotapes, videodiscs, television systems
• CPC Class Codes: G16H 20/70 relating to mental therapies, e.g. psychological therapy or autogenous training
• CPC Class Codes: Y02A 90/10 Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

A training program is configured to systematically drive neurological changes to treat depression, mood and anxiety disorders. In one embodiment, a reward renormalization game presents a plurality of stimuli, a subset of which are positively affective, and the remainder of which are neutral or negatively affective, and prompts a game participant to respond to the positively affective stimuli and ignore the remainder of the stimuli. In another embodiment, an inference renormalization game presents a plurality of stimuli, a subset of which are positively affective, a second subset of which are negatively affective, and a third subset of which are neutral and prompts a game participant to respond to both the positively affective stimuli and the negatively affective stimuli and ignore the neutral stimuli.

Claims

1. A training program comprising a combination of games configured to systematically drive neurological changes to treat major depressive disorder (MDD), the training program comprising:

a plurality of computerized processing speed, attention, and executive functioning games configured to treat different cognitive impairments associated with MDD, the plurality of games including;

a processing speed game that serves visual and/or auditory stimuli, wherein the processing speed game is effective in upregulating activities in cerebral attention networks that are impaired in a game participant diagnosed with MDD;

an executive task game that is effective in improving executive functioning in a game participant diagnosed with MDD; and

an inference renormalization game configured to;

present a plurality of stimuli, a subset of which are positively affective, a second subset of which are negatively affective, and a third subset of which are neutral;

prompt a game participant to respond to both the positively affective stimuli and the negatively affective stimuli and refrain from responding to the neutral stimuli;

receive the game participant'"'"'s input through a game piece;

provide an indication to the game participant of whether the game participant'"'"'s input was accurate; and

repeat the presenting through providing an indication steps over multiple repetitions while adapting one or more difficulty parameters to target maintenance of a success rate within a predetermined range.

2. The training program of claim 1, wherein the processing speed game prompts the game participant to discriminate between centrally presented visual stimuli and peripherally presented visual stimuli presented across a progressively expanding visual periphery.

3. The training program of claim 2, wherein the processing speed game presents the centrally presented visual stimuli at a progressively faster rate as the game progresses.

4. The training program of claim 1, wherein the processing speed game serves exaggerated phonemic and/or visual stimuli to the game participant and is effective in renormalizing auditory and/or visual processing speeds and accuracy in a game participant diagnosed with MDD.

5. The training program of claim 4, wherein the processing speed game presents auditory sound sweeps to the game participant.

6. The training program of claim 1, wherein the executive task game includes a divided attention game that prompts the game participant to evaluate one or more stimuli on the basis of a target characteristic or rule, challenges the game participant to identify whether the stimuli have the target characteristic or follow the rule, and repeats the prompting and challenging steps multiple times while changing the target characteristics or rules.

7. The training program of claim 6, wherein the divided attention game prompts the participant to evaluate one or more stimuli on the basis of a plurality of target conditional rules, each pertinent to a different target characteristic, and challenges the game participant to perform an action if either conditional rule is satisfied.

8. The training program of claim 1, wherein the executive task game prompts the game participant to discriminate a deviant shape against a constant background of shapes.

9. The training program of claim 1, wherein the executive task game prompts the game participant to identify whether an upside-down letter has been mirrored.

10. The training program of claim 1, further comprising one or more self-control and/or social-cognition games to improve cortical efficiency in front-cingulate pathways implicated in MDD and re-balance social control, interference resolution and social-emotional control.

11. The training program of claim 10, wherein the self-control and/or social-cognition games include flanker and emotional stroop tasks.

12. The training program of claim 11, wherein the self-control and/or social-cognition games include facial affect recognition training.

13. The training program of claim 1, wherein the inference renormalization game is configured to stop presenting the plurality of stimuli after presenting the plurality of stimuli for a brief time interval, and after stopping presentment of the plurality of stimuli, present a replacement stimulus;

and

to prompt the game participant to selectively respond to the replacement stimulus when it is a positively affective stimulus and to selectively withhold responding to the replacement stimulus when it is a negatively affective stimulus.

14. The training program of claim 1, wherein the negatively affective stimuli are stimuli that express a negative emotion, and the positively affective stimuli are stimuli that express a positive emotion.

15. The training program of claim 1, wherein the negatively and positively affective stimuli are facial expressions and/or vocal prosodies.

16. The training program of claim 1, further comprising progressively increasing the distractibility of the negatively affective stimuli.