Remote magnetic driven flow system

• US 9,603,742 B2
• Filed: 03/13/2014
• Issued: 03/28/2017
• Est. Priority Date: 03/13/2014
• Status: Active Grant

• Current Assignee: Alcon Incorporated
• Original Assignee: Novartis Ag
• Inventors: Sanchez, Robert, Lind, Casey
• Primary Examiner(s): Zalukaeva, Tatyana
• Assistant Examiner(s): KLEIN, BENJAMIN JACOB
• Application Number:
  US14/208,237
• Publication Number:
  US 20150257931A1
• Time in Patent Office: 1,111 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 2560/0257 using atmospheric pressure
• CPC Class Codes: A61B 5/036 by means introduced into body tracts A61B5/032 and A61B5/035 take precedence
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002

Abstract

A system for implantation in an eye of a patient includes a flow device sized for implantation into the eye of the patient. The flow device includes a fluid flow passageway and a flow system. The flow system may include a regulator having a magnetic element, and may be displaceable in the fluid flow passageway to affect flow through the fluid flow passageway. The system may also include a control device physically separate from the flow device and configured to be disposed outside the eye, the control device comprising an actuator magnetic field generator configured to act on the magnetic element to adjust the regulator in the flow system to selectively adjust flow through the flow device in response to changes in intraocular pressure.

Claims

1. A system for treatment of an ocular condition of a patient, comprising:

a flow device sized for implantation into the eye of the patient and including;

a housing including an inlet port and an outlet port;

a fluid flow passageway extending through the housing from the inlet port to the outlet port to allow the flow of fluid from the inlet port to the outlet port; and

a flow system disposed within the flow device, the flow system including a regulator having a magnetic element, wherein the regulator comprises a flexible membrane being displaceable in the fluid flow passageway to affect flow through the fluid flow passageway, the magnetic element forming a rigid portion that is part of the flexible membrane; and

a control device physically separate from the flow device and configured to be disposed outside the eye, the control device comprising a magnetic field generating actuator configured to act on the magnetic element to adjust the regulator in the flow system to selectively adjust flow through the flow device in response to changes in intraocular pressure.

2. The system of claim 1, wherein control device comprises an eyeglass frame.

3. The system of claim 1, wherein control device comprises a wearable article.

4. The system of claim 3, wherein the wearable article is one of a hat and a headband.

5. The system of claim 1, wherein the regulator includes a portion formed in the shape of an arch in cross-section, the magnetic element being disposed on the arch in a location that the arch displaces in a direction transverse to the flow direction in order to selectively restrict and allow fluid flow.

6. The system of claim 1, wherein the regulator is a flexible membrane portion and is configured to flex and move through the fluid flow passageway in the direction of the actuator when subjected to a magnetic field.

7. The system of claim 1, wherein the flow system comprises:

a first one-way valve disposed upstream from the regulator in the fluid flow passageway; and

a second one-way valve disposed downstream from the regulator in the fluid flow passageway, the regulator being actuatable to create a pumping effect with the first and second one-way valves.

8. The system of claim 1, wherein the control device comprises a power source larger than the flow device, the power source being configured to power the magnetic field generator.

9. The system of claim 7, wherein the flow device comprises:

a first sensor configured to detect pressure representative of pressure in an anterior chamber of the eye, wherein the first sensor is disposed upstream from the first one-way valve; and

a second sensor configured to detect pressure representative of pressure in a drainage site, wherein the second sensor is disposed downstream from the second one-way valve.

10. The system of claim 9, wherein the control device emits RF transmissions and wherein the flow device harvests power from the transmissions to power the first and second sensors.

11. A system for treatment of an ocular condition of a patient, comprising:

a housing including an inlet port and an outlet port;

a reservoir for maintaining a drug;

a fluid flow passageway extending through the housing from the inlet port to the outlet port to allow the flow of fluid from the inlet port to the outlet port;

a flow system disposed within the housing, the flow system including a regulator having a magnetic element, wherein the regulator comprises a flexible membrane that is displaceable in the fluid flow passageway to affect flow through the fluid flow passageway, the magnetic element forming a part of the flexible membrane; and

a control device physically separate from the housing and configured to be disposed outside the patient, the control device comprising a magnetic field generating actuator configured to act on the magnetic element to adjust the regulator in the flow system to selectively adjust flow through the housing.

12. The system of claim 11, wherein control device comprises a wearable article.

13. The system of claim 12, wherein the wearable article is one of a hat and a headband.

14. The system of claim 11, wherein the flexible membrane includes a portion formed in the shape of an arch in cross-section, the magnetic element being disposed on the arch in a location that the arch displaces in a direction transverse to the flow direction in order to selectively restrict or allow fluid flow.

15. The system of claim 11, wherein the reservoir for maintaining the drug includes a collapsible volume.

16. The system of claim 11, wherein the flow system comprises:

a first one-way valve disposed upstream from the regulator in the fluid flow passageway; and

a second one-way valve disposed downstream from the regulator in the fluid flow passageway, the regulator being actuatable to create a pumping effect with the first and second one-way valves.

17. A method of regulating fluid flow from an anterior chamber of an eye, comprising:

directing fluid through an implantable flow device including a housing defining a fluid flow passageway and including a flow system comprising a flexible membrane having a magnetic element that forms part of the flexible membrane and is responsive to a control device, wherein the control device is physically separate from the flow device and is configured to be disposed outside the eye to adjust flow through the fluid flow passageway; and

modifying an amount of drainage through the implantable flow device by creating a magnetic field with the control device.

18. The method of claim 17, wherein modifying the amount of drainage through the implantable flow device comprises activating an actuator to adjust the regulator to affect flow through the fluid flow passageway.

19. The method of claim 18, wherein modifying the amount of drainage through the implantable flow device comprises activating the actuator in response to the intraocular pressure exceeding a predetermined threshold.

20. The method of claim 19, wherein modifying the amount of drainage through the implantable flow device comprises activating the actuator to change the position of a sealing portion in the fluid flow passageway relative to the housing.