Methods and systems for treating neurological movement disorders
First Claim
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1. A method for reducing clinical presentation of a neurological movement disorder in a subject, the method comprising:
- (i) measuring field potentials from a primary motor cortex of the subject'"'"'s brain using at least one non-brain penetrating electrode;
(ii) calculating, with a processor, a modulation index for synchronization of brain rhythms in the measured field potentials, wherein the synchronization of brain rhythms in the measured field potentials comprises synchronization of phase of beta rhythm and amplitude of gamma activity; and
(iii) administering a deep brain stimulus to the subject when the calculated modulation index is outside of a predefined threshold range,wherein steps (i)-(iii) are continued in a manner effective to reduce the clinical presentation of the neurological movement disorder.
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Abstract
The present disclosure provides methods for reducing the clinical presentations of a neurological movement disorder in a subject. Aspects of the methods include measuring cortical local field potentials (LFPs) from the subject'"'"'s brain, calculating a modulation index related to brain synchronization from the LFPs, and administering deep brain stimulation to the subject if the calculated modulation index is outside of a threshold range. Also provided are devices, systems, and kits that may be used in practicing the subject methods.
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Citations
19 Claims
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1. A method for reducing clinical presentation of a neurological movement disorder in a subject, the method comprising:
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(i) measuring field potentials from a primary motor cortex of the subject'"'"'s brain using at least one non-brain penetrating electrode; (ii) calculating, with a processor, a modulation index for synchronization of brain rhythms in the measured field potentials, wherein the synchronization of brain rhythms in the measured field potentials comprises synchronization of phase of beta rhythm and amplitude of gamma activity; and (iii) administering a deep brain stimulus to the subject when the calculated modulation index is outside of a predefined threshold range, wherein steps (i)-(iii) are continued in a manner effective to reduce the clinical presentation of the neurological movement disorder. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 19)
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17. A system for reducing clinical presentations of a neurological movement disorder in a subject, the system comprising:
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a pulse generator configured to administer deep brain stimulation to a subject; a non-brain penetrating electrode adapted to record field potentials from a primary motor cortex of the subject; a processor in electronic communication with the pulse generator and the non-brain penetrating electrode, the processor programmed to; calculate a modulation index for synchronization of brain rhythms, wherein synchronization of brain rhythms comprises synchronization of phase of beta rhythm and amplitude of gamma activity; and administer the deep brain stimulation to the subject via the pulse generator when the calculated modulation index is outside of a predefined threshold range. - View Dependent Claims (18)
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Specification