Unwanted stimulation detection during cardiac pacing

• US 9,604,065 B2
• Filed: 08/26/2014
• Issued: 03/28/2017
• Est. Priority Date: 08/30/2013
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Rockweiler, Holly E., Olson, David C., Saha, Sunipa
• Primary Examiner(s): Layno, Carl H
• Assistant Examiner(s): GHAND, JENNIFER LEIGH-STEWAR
• Application Number:
  US14/469,322
• Publication Number:
  US 20150066103A1
• Time in Patent Office: 945 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 2562/0219 Inertial sensors, e.g. accelerometers, gyroscopes, tilt switches
• CPC Class Codes: A61B 5/1104 induced by stimuli or drugs; A61B5/1102 takes precedence; investigating medicinal preparations G01N33/15
• CPC Class Codes: A61B 5/1107 Measuring contraction of parts of the body, e.g. organ, muscle apparatus for measuring work or force in general G01L
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/388 Nerve conduction study, e.g. detecting action potential of peripheral nerves
• CPC Class Codes: A61B 5/4848 Monitoring or testing the effects of treatment, e.g. of medication
• CPC Class Codes: A61B 5/726 using Wavelet transforms
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay
• CPC Class Codes: A61N 1/3704 Circuits specially adapted therefor, e.g. for sensitivity control
• CPC Class Codes: A61N 1/371 Capture, i.e. successful stimulation

Abstract

The disclosure relates to systems and methods for cardiac rhythm management. In some cases, a system may include a pulse generator for generating pacing pulses for stimulating a heart of a patient; a memory; and a sensor configured to sense a response to a unwanted stimulation and to produce a corresponding sensor signal. A processing circuit may receive the sensor signal for a time after one or more pacing pulses, and may derive a time-frequency representation of the sensor signal based on the received sensor signal. The processing circuit may use the time-frequency representation of the sensor signal to help identify unwanted stimulation. Once unwanted stimulation is detected, the processing circuit may change the pacing pulses to help reduce or eliminate the unwanted stimulation.

Claims

1. A system for cardiac rhythm management comprising:

a pulse generator for generating pacing pulses for stimulating a heart of a patient;

a memory;

a sensor configured to sense a response to a stimulation of a phrenic nerve of the patient and to produce a corresponding sensor signal;

a processing circuit in communication with the memory and the sensor, the processing circuit configured to;

receive the sensor signal for a time after one or more pacing pulses;

derive a time-frequency representation of the sensor signal based on the received sensor signal using wavelets;

identify a dominant frequency component in the time-frequency representation of sensor signal;

determine if the dominant frequency component falls within a predetermined frequency range;

identify a time of occurrence of the dominant frequency component relative to a corresponding pacing pulse;

determine if the time of occurrence of the dominant frequency component occurs within a predetermined time window;

determine if the phrenic nerve of the patient has been stimulated based, at least in part, on the time-frequency representation of the sensor signal such that the dominant frequency component falls within the predetermined frequency range and the dominant frequency component occurs within the predetermined time window;

store a phrenic nerve stimulation event identifier in the memory if the processing circuit determines that the phrenic nerve of the patient has been stimulated.

2. The system of claim 1, wherein the sensor includes one or more of an accelerometer, a minute ventilation sensor, an electrical signal sensor, a pressure sensor, and an acoustic sensor that is/are configured to sense a measure indicative of stimulation of the phrenic nerve of the patient.

3. The system of claim 1, wherein the sensor includes an accelerometer that is configured to sense an acceleration indicative of a response to a stimulation of the phrenic nerve of the patient.

4. The system of claim 1, wherein the dominant frequency component is a mean of two or more dominant frequency components resulting from each of two or more pacing pulses.

5. The system of claim 1, wherein the dominant frequency component is determined by a centroid of a feature in a time-frequency representation of the sensor signal based on the received sensor signal using wavelets.

6. The system of claim 1, wherein the time of occurrence of the dominant frequency component relative to the predetermined time window is determined by a centroid of a feature in a time-frequency representation of the sensor signal based on the received sensor signal using wavelets.

7. The system of claim 1, wherein the processing circuit further determines if the dominant frequency component meets a predetermined quality threshold, and wherein the phrenic nerve of the patient is determined to have been stimulated when the dominant frequency component meets a predetermined quality threshold, the dominant frequency component falls within the predetermined frequency range and the dominant frequency component occurs within the predetermined time window.

8. The system of claim 1, wherein the pulse generator provides the pacing pulse to the heart of the patient after an atrio-ventricular delay, and wherein the pulse generator changes the atrio-ventricular delay, and the processing circuit repeats the receiving through determining steps to determine if the phrenic nerve of the patient has been stimulated.

9. The system of claim 1, wherein the time-frequency representation of the sensor signal is derived using Morlet wavelets and/or a continuous wavelet transform.

10. The system of claim 1, wherein the processing circuit further is configured to generate pacing pulses for stimulating the heart of a patient that are anticipated to both capture the heart and to minimize phrenic nerve stimulation by the generated pacing pulses;

and

determine if capture of the heart has been achieved.

11. A method for determining if a phrenic nerve of a patient is stimulated by one or more pacing pulses of a cardiac pacemaker, comprising:

receiving a sensor signal for a time after one or more pacing pulses, wherein the sensor signal is provided by a sensor that can sense a stimulation of the phrenic nerve of the patient;

determining a time-frequency representation of the sensor signal based on the received sensor signal;

identifying a dominant frequency component in the time-frequency representation of sensor signal;

determining if the dominant frequency component falls within a predetermined frequency range;

identifying a time of occurrence of the dominant frequency component relative to a corresponding pacing pulse;

determining if the time of occurrence of the dominant frequency component occurs within a predetermined time window; and

determining if the phrenic nerve of the patient has been stimulated based, at least in part, on the time-frequency representation of the sensor signal such that the dominant frequency component falls within the predetermined frequency range and the dominant frequency component occurs within the predetermined time window.