Techniques and methods for storing and transferring registration, atlas, and lead information between medical devices

• US 9,604,067 B2
• Filed: 08/01/2013
• Issued: 03/28/2017
• Est. Priority Date: 08/04/2012
• Status: Active Grant

• Current Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Inventors: Kothandaraman, Sridhar, Moffitt, Michael A.
• Primary Examiner(s): Koharski, Christopher D
• Assistant Examiner(s): Bays, Pamela M
• Application Number:
  US13/957,353
• Publication Number:
  US 20140039577A1
• Time in Patent Office: 1,335 Days
• Field of Search: 607/45, 607/46, 607/59, 607/60
• US Class Current: 1/1
• CPC Class Codes: A61B 2034/107 Visualisation of planned trajectories or target regions
• CPC Class Codes: A61B 2090/364 Correlation of different images or relation of image positions in respect to the body
• CPC Class Codes: A61B 34/10 Computer-aided planning, simulation or modelling of surgical operations
• CPC Class Codes: A61B 34/20 Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
• CPC Class Codes: A61N 1/0529 Electrodes for brain stimulation
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/36062 Spinal stimulation
• CPC Class Codes: A61N 1/37235 Aspects of the external programmer

Abstract

A neurostimulator system includes a portable component configured for storing patient-specific data, and an external control device configured for obtaining the patient-specific data from the portable component. The portable component is an implantable neurostimulator, a patient'"'"'s remote controller, and/or an external charger. The patient-specific data is imaging-related data. A method of storing data in a neurostimulation system includes generating patient-specific data, and storing the patient-specific data in at least one of the portable components. A method for programming the implantable neurostimulator includes receiving the patient-specific data from the portable component, simulating a volume of tissue activation for each of one or more candidate stimulation parameters, wherein the simulation is based at least in part on the patient-specific data, selecting at least one of the candidate stimulation parameters, and programming the implantable neurostimulator with the selected stimulation parameters.

Claims

1. A method of storing data in a neurostimulation system, the method comprising:

generating a first image of a patient'"'"'s brain and a second image of the patient'"'"'s brain, the first image generated before a plurality of electrodes are implanted within the patient'"'"'s brain and the second image generated after the plurality of electrodes are implanted within the patient'"'"'s brain;

generating patient-specific imaging-related data indicating a location of the plurality of electrodes within the patient'"'"'s brain, the patient-specific imaging-related data generated based on both of the first and second images, wherein the patient-specific imaging-related data is at least one of imaging data of the patient'"'"'s brain or a transformation data set to transform a generic 3D atlas into a patient-specific 3D atlas; and

storing the patient-specific imaging-related data in a portable component of the neurostimulation system, wherein the portable component is selected from the group consisting of an implantable neurostimulator coupled to the plurality of electrodes implanted within the patient'"'"'s brain and an external charger for transcutaneously charging the implantable neurostimulator, wherein the portable component is either a) implanted in the patient, b) configured and arranged to be worn by the patient, or c) configured and arranged to fit in a palm of a hand of the patient.

2. The method of claim 1, wherein generating the patient-specific imaging-related data comprises generating the imaging data of the patient'"'"'s brain.

3. The method of claim 2, wherein the imaging data comprises at least one of magnetic resonance imaging data, diffusion tensor imaging data, and computed tomography scan data.

4. The method of claim 1, wherein generating the patient-specific imaging-related data comprises generating the transformation data set using a transformation procedure that transforms the generic 3D atlas into the patient-specific 3D atlas.

5. The method of claim 4, wherein the transformation data set comprises lead orientation information.

6. The method of claim 4, wherein the transformation data set comprises a 4×

4 matrix.

7. The method of claim 4, wherein the transformation procedure comprises identifying at least three anatomical reference points in a given image of the patient'"'"'s brain, and, based on locations of three corresponding reference points in the generic 3D atlas, transforming the generic 3D atlas into the patient-specific 3D atlas.

8. The method of claim 7, wherein the at least three anatomical reference points are an anterior commissure, a posterior commissure, and a mid-commissural point of the patient'"'"'s brain.

9. The method of claim 1, wherein generating the patient-specific imaging-related data comprises performing a registration process between a series of magnetic resonance images and a computed tomography scan image, wherein the series of magnetic resonance images is obtained prior to implanting the plurality of electrodes, and the computer tomography scan image is obtained after implanting the plurality of electrodes.

10. The method of claim 1, wherein storing the patient-specific imaging-related data comprises storing the patient-specific imaging-related data in the implanted neurostimulator.

11. The method of claim 1, wherein storing the patient-specific imaging-related data comprises storing the patient-specific imaging-related data in the external charger.

12. A neurostimulator system comprising:

a plurality of electrodes implanted within a patient'"'"'s brain tissue;

a portable component configured for storing patient-specific imaging-related data including a location of the plurality of electrodes within the patient'"'"'s brain tissue, determined by imaging of the patient'"'"'s brain tissue, as compared to an image of the patient'"'"'s brain tissue prior to implantation of the plurality of electrodes, wherein the patient-specific imaging-related data is at least one of imaging data of the patient'"'"'s brain tissue or a transformation data set to transform a generic 3D atlas into a patient-specific 3D atlas, the portable component selected from the group consisting of;

an implantable neurostimulator and an external charger for transcutaneously charging the implantable neurostimulator, wherein the portable component is either a) implantable in the patient, b) configured and arranged to be worn by the patient, or c) configured and arranged to fit in a palm of a hand of the patient; and

an external control device configured for obtaining the patient-specific imaging-related data from the portable component, generating a patient-specific anatomical atlas from the patient-specific image-related data, and programming, the portable component with at least one stimulation parameter based on the patient-specific anatomical atlas.

13. The system of claim 12, wherein the patient-specific imaging-related data is the imaging data of the patient'"'"'s brain tissue.

14. The system of claim 13, wherein the imaging data comprises at least one of magnetic resonance imaging data, diffusion tensor imaging data, and computed tomography scan data.

15. The system of claim 12, wherein the patient-specific imaging-related data is the transformation data set, and wherein the external control device is further configured for generating the patient-specific 3D atlas from the transformation data set and a general anatomical atlas.

16. The system of claim 15, wherein the transformation data set comprises lead orientation information.

17. The system of claim 15, wherein the transformation data set comprises a 4×

4 matrix.

18. The system of claim 15, wherein the external control device is configured for simulating a volume of tissue activation for each of one or more candidate stimulation parameters, wherein the simulation is based at least in part on the patient-specific imaging-related data, and selecting at least one of the one or more candidate stimulation parameters, and programming the implantable neurostimulator with the at least one selected stimulation parameter.

19. A method for programming an implantable neurostimulator coupled to a plurality of electrodes that are implanted within a patient'"'"'s brain, comprising:

imaging the patient'"'"'s brain to determine an implanted location of the plurality of electrodes within the patient'"'"'s brain;

receiving patient-specific imaging-related data from a portable component selected from the group consisting of;

the implantable neurostimulator and an external charger for transcutaneously charging the implantable neurostimulator, wherein the portable component is either a) implantable in the patient, b) configured and arranged to be worn by the patient, or c) configured and arranged to fit in a palm of a hand of the patient, wherein the patient-specific imaging-related data is at least one of imaging data of the patient'"'"'s brain or a transformation data set to transform a generic 3D atlas into a patient-specific 3D atlas;

generating a patient-specific anatomical atlas from the patient-specific image-related data including the location of the plurality of electrodes within the patient'"'"'s brain, determined by the imaging of the patient'"'"'s brain, as compared to an image of the patient'"'"'s brain prior to implantation of the plurality of electrodes; and

programming the portable component with at least one stimulation parameter based on the patient-specific anatomical atlas.

20. The method of claim 19, wherein the patient-specific imaging-related data comprises the imaging data of the patient'"'"'s brain.

21. The method of claim 20, wherein the imaging data comprises at least one of magnetic resonance imaging data, diffusion tensor imaging data, and computed tomography scan data.

22. The method of claim 19, wherein the patient-specific imaging-related data is the transformation data set, and wherein the method further comprises using the transformation data set to transform the generic 3D atlas into the patient-specific 3D atlas.

23. The method of claim 22, wherein the transformation data set comprises lead orientation information.

24. The method of claim 22, wherein the transformation data set comprises a 4×

4 matrix.

25. The method of claim 19, further comprising:

simulating a volume of tissue activation for each of one or more candidate stimulation parameters, wherein the simulation is based at least in part on the patient-specific imaging-related data;

selecting at least one of the one or more candidate stimulation parameters; and

programming the implantable neurostimulator with the at least one selected stimulation parameter.