Methods and processes for non-invasive assessment of genetic variations
First Claim
Patent Images
1. A method for enriching fetal nucleic acid in sample nucleic acid that includes fetal nucleic acid and maternal nucleic acid, comprising:
- (a) obtaining cell-free circulating sample nucleic acid from a biological sample from a pregnant female; and
(b) separating some or substantially all of the fetal nucleic acid from the maternal nucleic acid by contacting the sample nucleic acid with a H1M-specific antibody or H1FOO-specific antibody, thereby generating a separation product enriched for fetal nucleic acid relative to fetal nucleic acid in the sample nucleic acid.
2 Assignments
0 Petitions
Accused Products
Abstract
Technology provided herein relates in part to methods, processes and apparatuses for non-invasive assessment of genetic variations.
224 Citations
8 Claims
-
1. A method for enriching fetal nucleic acid in sample nucleic acid that includes fetal nucleic acid and maternal nucleic acid, comprising:
-
(a) obtaining cell-free circulating sample nucleic acid from a biological sample from a pregnant female; and (b) separating some or substantially all of the fetal nucleic acid from the maternal nucleic acid by contacting the sample nucleic acid with a H1M-specific antibody or H1FOO-specific antibody, thereby generating a separation product enriched for fetal nucleic acid relative to fetal nucleic acid in the sample nucleic acid. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
-
Specification