Arrays of integrated analytical devices
First Claim
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1. An array of integrated analytical devices, each device comprising:
- a nanoscale emission volume;
a detector layer optically coupled to the nanoscale emission volume;
a diffractive beam shaping element disposed between the nanoscale emission volume and the detector layer; and
a color filtration layer disposed between the diffractive beam shaping element and the detector layer, wherein the color filtration layer comprises 2 to 9 color filtration elements, each color filtration element specific for a range of light wavelengths;
wherein light is emitted from the nanoscale emission volume by a plurality of emitters within the emission volume;
wherein the detector layer comprises a plurality of sensing regions, and wherein the sensing regions are optically coupled to the color filtration elements; and
wherein the diffractive beam shaping element spatially separates the light emitted from the nanoscale emission volume into a plurality of beams and directs the spatially-separated light beams through the color filtration elements and onto the sensing regions.
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Abstract
Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices include an integrated diffractive beam shaping element that provides for the spatial separation of light emitted from the optical reactions.
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Citations
27 Claims
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1. An array of integrated analytical devices, each device comprising:
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a nanoscale emission volume; a detector layer optically coupled to the nanoscale emission volume; a diffractive beam shaping element disposed between the nanoscale emission volume and the detector layer; and a color filtration layer disposed between the diffractive beam shaping element and the detector layer, wherein the color filtration layer comprises 2 to 9 color filtration elements, each color filtration element specific for a range of light wavelengths; wherein light is emitted from the nanoscale emission volume by a plurality of emitters within the emission volume; wherein the detector layer comprises a plurality of sensing regions, and wherein the sensing regions are optically coupled to the color filtration elements; and wherein the diffractive beam shaping element spatially separates the light emitted from the nanoscale emission volume into a plurality of beams and directs the spatially-separated light beams through the color filtration elements and onto the sensing regions. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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Specification