Autonomous gamma, X-ray, and particle detector

• US 9,606,245 B1
• Filed: 03/24/2016
• Issued: 03/28/2017
• Est. Priority Date: 03/24/2015
• Status: Active Grant

• Current Assignee: Cornell University, Memorial Sloan-Kettering Cancer Center, The Research Foundation for The State University of New York (State University of New York), University of South Carolina
• Original Assignee: Cornell University, Memorial Sloan-Kettering Cancer Center, The Research Foundation for The State University of New York (State University of New York), University of South Carolina
• Inventors: Czarnecki, Steve, Krol, Andrzej, Mandal, Krishna, Schmidtlein, C. Ross, Turner, James, Poliks, Mark D., Thompson, Michael
• Primary Examiner(s): Gaworecki, Mark R
• Application Number:
  US15/080,073
• Time in Patent Office: 369 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 6/037 Emission tomography
• CPC Class Codes: A61B 6/501 for diagnosis of the head, e.g. neuroimaging or craniography
• CPC Class Codes: G01T 1/1642 using a scintillation crystal and position sensing photodetector arrays, e.g. ANGER cameras
• CPC Class Codes: G01T 1/2006 using a combination of a scintillator and photodetector which measures the means radiation intensity
• CPC Class Codes: G01T 1/20181 Stacked detectors, e.g. for measuring energy and positional information using a combination of different types of scintillation detectors, e.g. phoswich detectors, G01T1/2008
• CPC Class Codes: G01T 1/20182 Modular detectors, e.g. tiled scintillators or tiled photodiodes stacked detectors G01T1/20181
• CPC Class Codes: G01T 1/20183 Arrangements for preventing or correcting crosstalk, e.g. optical or electrical arrangements for correcting crosstalk
• CPC Class Codes: G01T 1/20185 Coupling means between the photodiode and the scintillator, e.g. optical couplings using adhesives with wavelength-shifting fibres
• CPC Class Codes: G01T 1/208 Circuits specially adapted for scintillation detectors, e.g. for the photo-multiplier section
• CPC Class Codes: G01T 1/245 using memory cells

Abstract

A system and method for imaging gamma- and x-ray, and charged particles sources employing a three dimensional array of scintillation elements arranged surrounding an emission source. According to a preferred embodiment, each element of the array comprises a scintillator element, a solid-state photon detector, and processing electronics to output an electronic signal. The elements may be efficiently packed in both the X-Y plane and stacked in the Z-axis, to provide depth of interaction information. The elements of the array are preferably hierarchically arranged with control electronics provided together for subarray modules (e.g., an n×m×1 module), and synchronization electronics provided at a larger scale. The modules preferably communicate with a control system through a shared addressable packet switched digital communication network with a control and imaging system, and receive control information from that system through the network.

Claims

1. An autonomous scintillation detector comprising:

a plurality of scintillator elements arranged in an array;

a plurality of detectors, each respective detector being coupled to a respective scintillator element and being configured to selectively detect scintillation of the respective coupled scintillator element;

wherein each respective scintillator element at least one of;

is optically and electrically isolated from each other scintillator element of the array; and

comprises a scintillation crystal, and each detector comprises a thin film photonic detector directly patterned on a surface of each respective scintillation crystal;

a clock, configured to generate a clock signal having a resolution of less than or equal to 10 nS;

circuitry coupled to each of the plurality of detectors and receiving the clock signal, configured to produce a detection event in response to excitation of a respective scintillator element, the detection event comprising a quantitative scintillation parameter and a time of detection;

a memory;

an interface to a shared addressable digital packet communication network;

an automated processor configured to;

store a plurality of records representing a plurality of detection events in the memory, each record comprising a respective detection event and an identification of a respective scintillation element associated with the respective detection event;

process the stored plurality of records according to at least one filter criteria;

transmit the stored records through the shared addressable digital packet communication network; and

receive control information through the shared addressable digital packet communication network; and

a housing configured to surround at least the plurality of scintillator elements, the plurality of detectors, the clock, the circuitry, the memory, and the automated processor.

2. The detector according to claim 1, further comprising a frame configured to support a plurality of autonomous scintillation detectors in a three dimensional array surrounding an object-under-test region.

3. The detector according to claim 2, wherein the plurality of autonomous scintillation detectors are provided in a sheet array surrounding the object-under-test region, wherein the sheet is deformable and configured to assume a plurality of different non-planar configurations.

4. The detector according to claim 2, wherein the plurality of autonomous scintillation detectors are provided as plurality of stacked sheet arrays, each sheet array comprising a plurality of the scintillation detectors.

5. The detector according to claim 1, wherein the automated processor is further configured to compensate the quantitative scintillation parameter for perturbations caused by at least one of temperature and dark current of each detector.

6. The detector according to claim 1, wherein the filter criteria comprises a detected scintillation energy range, the automated processor being further configured to exclude from transmission records associated with detection events having a detected scintillation energy outside a respective detected scintillation energy range.

7. The detector according to claim 1, wherein the filter criteria comprises a dead time after a detection event, the automated processor being further configured to exclude detection of a subsequent detection event during the dead time.

8. The detector according to claim 1, wherein the automated processor is further configured to manage a power consumption of the autonomous scintillation detector.

9. The detector according to claim 1, wherein each scintillation element comprises a scintillation crystal, and each detector comprises a thin film photonic detector directly patterned on a surface of each respective scintillation crystal.

10. The detector according to claim 1, wherein the detector comprises a silicon photonic sensor, and the circuitry comprises an analog-to-digital converter, a buffer, and clock synchronization and time skew management logic integrated together with the silicon photonic detector.

11. The detector according to claim 1, wherein the automated processor is further configured to determine positional reference information, to establish spatial coordinates of the autonomous scintillation detector with respect to at least one other autonomous scintillation detector.

12. The detector according to claim 1, wherein the interface to the shared addressable digital packet communication network comprises an interface to a wireless digital radio frequency communication local area network.

13. The detector according to claim 1, wherein each scintillator element is optically and electrically isolated from each other scintillator element of the array.

14. A scintillation detector array comprising a plurality of autonomous scintillation detectors according to claim 1 arranged in a three dimensional distribution about a sensing region, each respective autonomous scintillation detector having the respective automated processor configured to transmit the respective records through a common shared addressable digital packet communication network to a remote server.

15. The scintillation detector array according to claim 14, wherein the three dimensional distribution is configured to surround an upper portion of a human skull, and to be physically supportable by an unconstrained adult human subject.

16. A scintillation detector module, comprising:

a clock, configured to produce a clock signal representing a time;

a plurality of scintillation elements, each scintillation element being responsive to emissions to produce scintillation events associated with a quantity of photons;

a respective detector associated with each of the plurality of scintillation elements, configured to produce an electrical signal corresponding to the quantity of photons;

wherein each respective scintillator element at least one of;

is optically and electrically isolated from each other scintillator element in an array comprising the plurality of scintillation elements; and

comprises a scintillation crystal, and each respective detector comprises a thin film photonic detector directly patterned on a surface of each respective scintillation crystal;

at least one electronic circuit, configured to receive the electrical signal produced by each respective detector, and to produce a digitized output which preserves at least information comprising the quantity of photons;

a digital memory, configured to store a plurality of records, each record comprising at least an identifier of a respective scintillation crystal, a time of a respective a respective emission and the information comprising the quantity of photons association with the respective emission;

a digital communication interface, configured to communicate digital information packets through a shared addressable digital packet communication network; and

an automated processor, configured to selectively process the information comprising the quantity of photons selectively in dependence on the quantity of photons for each respective scintillation event, transmit the stored plurality of records and receive control information through the digital communication interface.

17. The scintillation detector module according to claim 16, further comprising a housing which contains the plurality of scintillation elements, the respective detector associated with each of the plurality of scintillation elements, the at least one electronic circuit, the digital memory, the digital communication interface, and the automated processor.

18. The scintillation detector module according to claim 16, in combination with at least one additional scintillation detector module and a control system, the control system being configured to:

receive the communicated digital information packets through the shared addressable digital packet communication network from each of the scintillation detector module and the at least one additional scintillation detector module;

send control information through the shared addressable digital packet communication network to each of the scintillation detector module and the at least one additional scintillation detector module;

determine records corresponding to temporally coincident scintillation events from each of the scintillation detector module and the at least one additional scintillation detector module; and

generate image information dependent on the determined records.

19. A scintillation detection method comprising:

providing a plurality of autonomous scintillation detectors surrounding a space, each autonomous scintillation detector comprising;

a plurality of scintillator elements arranged in an array;

a plurality of detectors, each respective detector being coupled to a respective scintillator element and being configured to selectively detect scintillation of the respective coupled scintillator element;

wherein each respective scintillator element at least one of;

is optically and electrically isolated from each other scintillator element of the array; and

comprises a scintillation crystal, and each detector comprises a thin film photonic detector directly patterned on a surface of each respective scintillation crystal;

a clock, configured to generate a clock signal having a resolution of less than or equal to 10 nS;

circuitry coupled to each of the plurality of detectors and receiving the clock signal, configured to produce a detection event in response to excitation of a respective scintillator element, the detection event comprising a quantitative scintillation parameter and a time of detection;

a memory;

an interface to a shared addressable digital packet communication network;

an automated processor configured to;

store a plurality of records representing a plurality of detection events in the memory, each record comprising a respective detection event and an identification of a respective scintillation element associated with the respective detection event;

process the stored plurality of records according to at least one filter criteria;

transmit the stored records through the shared addressable digital packet communication network; and

receive control information through the shared addressable digital packet communication network; and

a housing configured to surround at least the plurality of scintillator elements, the plurality of detectors, the clock, the circuitry, the memory, and the automated processor;

receiving the communicated digital information packets through the shared addressable digital packet communication network from plurality of autonomous scintillation detectors;

transmitting control information through the shared addressable digital packet communication network to the plurality of autonomous scintillation detectors;

determining, records corresponding to temporally coincident scintillation events from each of the scintillation detector module and the at least one additional scintillation detector module; and

generating image information dependent on the determined records.

20. The scintillation detection method according to claim 19, wherein the filter criteria comprises a detected scintillation energy range, further comprising excluding from transmission by a respective autonomous scintillation detector, records associated with detection events having a detected scintillation energy outside a respective detected scintillation energy range.