Immobilized bioactive hydrogel matrices as surface coatings

• US 9,610,382 B2
• Filed: 11/07/2013
• Issued: 04/04/2017
• Est. Priority Date: 02/21/2002
• Status: Expired due to Term

• Current Assignee: Pioneer Surgical Technology Incorporated (Surgalign Holdings, Inc.)
• Original Assignee: RTI Surgical Incorporated
• Inventors: Lamberti, Francis Vincent, Klann, Richard Chris, Hill, Ronald Stewart
• Primary Examiner(s): Arnold, Ernst V
• Application Number:
  US14/074,296
• Publication Number:
  US 20140066694A1
• Time in Patent Office: 1,244 Days
• CPC Class Codes: A61F 2/0063 Implantable repair or support meshes, e.g. hernia meshes
• CPC Class Codes: A61K 47/42 Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein oligopeptides having up to five amino acids A61K47/183; polyamino acids A61K47/34
• CPC Class Codes: A61L 2300/112 Phosphorus-containing compounds, e.g. phosphates, phosphonates
• CPC Class Codes: A61L 2300/412 Tissue-regenerating or healing or proliferative agents
• CPC Class Codes: A61L 2420/04 Coatings containing a composite material such as inorganic/organic, i.e. material comprising different phases
• CPC Class Codes: A61L 2420/06 Coatings containing a mixture of two or more compounds
• CPC Class Codes: A61L 2430/02 for reconstruction of bones; weight-bearing implants
• CPC Class Codes: A61L 27/025 Other specific inorganic materials not covered by A61L27/04 - A61L27/12
• CPC Class Codes: A61L 27/12 Phosphorus-containing materials, e.g. apatite
• CPC Class Codes: A61L 27/20 Polysaccharides
• CPC Class Codes: A61L 27/22 Polypeptides or derivatives thereof , e.g. degradation products
• CPC Class Codes: A61L 27/222 Gelatin
• CPC Class Codes: A61L 27/24 Collagen
• CPC Class Codes: A61L 27/26 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/3608 Bone, e.g. demineralised bone matrix [DBM], bone powder
• CPC Class Codes: A61L 27/446 with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
• CPC Class Codes: A61L 27/46 with phosphorus-containing inorganic fillers
• CPC Class Codes: A61L 27/52 Hydrogels or hydrocolloids
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 31/10 : Macromolecular materials
• CPC Class Codes: A61P 19/00 : Drugs for skeletal disorders
• CPC Class Codes: A61P 37/00 : Drugs for immunological or allergic disorders
• CPC Class Codes: A61P 7/00 : Drugs for disorders of the blood or the extracellular fluid
• CPC Class Codes: B29C 39/003 : characterised by the choice of material
• CPC Class Codes: B29L 2031/7532 : Artificial members, protheses
• CPC Class Codes: C08L 5/02 : Dextran; Derivatives thereof
• CPC Class Codes: C08L 89/00 : Compositions of proteins; Compositions of derivatives thereof foodstuff preparations A23J3/00
• CPC Class Codes: Y10T 428/29 : Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
• CPC Class Codes: Y10T 428/2947 : Synthetic resin or polymer in plural coatings, each of different type
• CPC Class Codes: Y10T 428/31551 : Of polyamidoester [polyurethane, polyisocyanate, polycarbamate, etc.]
• CPC Class Codes: Y10T 428/31786 : Of polyester [e.g., alkyd, etc.]

Abstract

The present invention is directed to a stabilized bioactive hydrogel matrix coating for substrates, such as medical devices. The invention provides a coated substrate comprising a substrate having a surface, and a bioactive hydrogel matrix layer overlying the surface of the medical device, the hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component, the first and second high molecular weight components each being selected from the group consisting of polyglycans and polypeptides, wherein at least one of the first and second high molecular weight components is immobilized (e.g., by covalent cross-linking) to the surface of the substrate.

Claims

1. A coated tissue supporting mesh comprising:

a mesh implant having a surface and being adapted for providing one or both of structural and mechanical support to contacted tissue; and

a hydrogel matrix comprising a polyglycan, a polypeptide comprising gelatin, and at least one enhancing agent selected from the group consisting of polar amino acids, divalent cation chelators, and combinations thereof;

wherein the polyglycan is dextran or oxidized dextran;

wherein the hydrogel matrix is solid or semi-solid at physiological temperature and physiological pH; and

wherein the hydrogel matrix is overlying the surface of the mesh implant and is immobilized thereon.

2. The coated tissue supporting mesh according to claim 1, wherein the mesh is formed of a thermoplastic polymer.

3. The coated tissue supporting mesh according to claim 1, wherein the mesh is formed of a metallic material.

4. The coated tissue supporting mesh according to claim 1, wherein the polyglycan and polypeptide are covalently cross-linked to each other.

5. The coated tissue supporting mesh according to claim 1, wherein at least one of the polyglycan and the polypeptide is covalently cross-linked to the surface of the mesh implant.

6. A coated implant comprising:

a flexible implant comprising a thermoplastic polymer and having a surface; and

a hydrogel matrix comprising a polyglycan, a polypeptide comprising gelatin, and at least one enhancing agent selected from the group consisting of polar amino acids, divalent cation chelators, and combinations thereof;

wherein the polyglycan is dextran or oxidized dextran;

wherein the hydrogel matrix is solid or semi-solid at physiological temperature and physiological pH; and

wherein the hydrogel matrix is overlying the surface of the flexible implant and is immobilized thereon.

7. The coated implant according to claim 6, wherein the implant is a mesh.

8. The coated implant according to claim 6, wherein the polyglycan and polypeptide are covalently cross-linked to each other.

9. The coated implant according to claim 6, wherein at least one of the polyglycan and the polypeptide is covalently cross-linked to the surface of the flexible implant.