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Immobilized bioactive hydrogel matrices as surface coatings

  • US 9,610,382 B2
  • Filed: 11/07/2013
  • Issued: 04/04/2017
  • Est. Priority Date: 02/21/2002
  • Status: Expired due to Term
First Claim
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1. A coated tissue supporting mesh comprising:

  • a mesh implant having a surface and being adapted for providing one or both of structural and mechanical support to contacted tissue; and

    a hydrogel matrix comprising a polyglycan, a polypeptide comprising gelatin, and at least one enhancing agent selected from the group consisting of polar amino acids, divalent cation chelators, and combinations thereof;

    wherein the polyglycan is dextran or oxidized dextran;

    wherein the hydrogel matrix is solid or semi-solid at physiological temperature and physiological pH; and

    wherein the hydrogel matrix is overlying the surface of the mesh implant and is immobilized thereon.

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