Systems, devices, and methods for transdermal delivery

• US 9,610,440 B2
• Filed: 06/10/2014
• Issued: 04/04/2017
• Est. Priority Date: 06/10/2013
• Status: Active Grant

• Current Assignee: Rare Beauty Brands, Inc.
• Original Assignee: Iontera, Inc.
• Inventors: Jordan, Michael K, Hobson, Christopher A, Cao, Miaoyong, Gibson, Matthew
• Primary Examiner(s): Sirmons, Kevin C
• Assistant Examiner(s): CARPENTER, WILLIAM R
• Application Number:
  US14/301,055
• Publication Number:
  US 20140364794A1
• Time in Patent Office: 1,029 Days
• CPC Class Codes: A61M 2037/0007 having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
• CPC Class Codes: A61N 1/0436 Material of the electrode
• CPC Class Codes: A61N 1/044 Shape of the electrode
• CPC Class Codes: A61N 1/0496 characterised by using specific chemical compositions, e.g. hydrogel compositions, adhesives
• CPC Class Codes: A61N 1/303 Constructional details electrodes for external use A61N1/0428

Abstract

Disclosed herein are systems, devices, and methods for transdermal delivery of a therapeutic agent (for example, a molecule or molecules) to a therapy site. The systems, devices, and methods described herein are flexible and able to conform to the contours of a therapy site, such as the shape of a user'"'"'s face. In certain approaches, the devices and systems described herein include an integrated power supply for standalone application to the therapy site. The devices, systems, and methods include flexible electrodes with integrated conductance layers and interface layers for improved stability and current distribution. In practice, the device includes at least two electrodes which are coupled to the therapy site. When the electrodes are placed at the therapy site, they are electrically coupled, thereby drawing a current from the power supply to deliver the therapeutic agent to the therapy site.

Claims

1. A method for delivering a therapeutic molecule to a therapy site, comprising:

providing a flexible delivery device having a power supply, a first electrode, a second electrode, and a cured gel coupling layer, wherein the first electrode and second electrode are spaced apart by a separation channel;

spraying a serum containing a therapeutic molecule to an exterior surface of the cured gel coupling layer;

allowing the serum to at least partially diffuse into the cured gel coupling layer;

placing the cured gel coupling layer with the serum onto the therapy site to electrically couple the first electrode and the second electrode through a portion of the therapy site, thereby drawing a current from the power supply to deliver the therapeutic molecule to the therapy site;

removing the flexible delivery device from the therapy site; and

applying the serum a second time to the exterior layer surface of the cured gel coupling layer, wherein the second application of serum restores at least some adhesive properties of the cured gel coupling layer.

2. The method of claim 1, wherein the molecule has a non-neutral charge.

3. The method of claim 1, wherein the first electrode has a first interface layer integrally coupled to a first conductance layer, wherein the first conductance layer is electrically coupled to a first terminal of the power supply.

4. The method of claim 1, wherein the second electrode has a second interface layer integrally coupled to a second conductance layer, wherein the second conductance layer is electrically coupled to a second terminal of the power supply.

5. The method of claim 1, further comprising flexing the delivery device to conform to the shape of the therapy site.

6. The method of claim 1, further comprising adhering the delivery device to the therapy site by directing a portion of the cured gel directly on the therapy site.

7. The method of claim 1, wherein the power supply, first electrode, and second electrode are coupled to an upper base layer.

8. The method of claim 1, wherein the first electrode has a first coupling layer and the second electrode has a second coupling layer, wherein the first coupling layer and second coupling layer contact the therapy site when the first electrode and second electrode are placed on the therapy site.

9. The method of claim 1, further comprising cleaning the exterior layer surface of the cured gel coupling layer prior to applying the serum a second time.

10. The method of claim 1, wherein a release liner is immediately applied to the cured-gel layer after the spraying step, such that more moisture may be retained in the cured gel coupling layer, and the cured gel coupling layer has increased adhesive properties that more readily conform to a user'"'"'s tissue and maintain contact during wear.

11. The method of claim 1, further comprising placing the cured gel coupling layer after the application of serum a second time onto the therapy site or a second therapy site to electrically couple the first electrode and the second electrode through a portion of the therapy site or second therapy site, thereby drawing current from the power supply to deliver the therapeutic molecule to the therapy site.