Fluid delivery devices, systems, and methods

• US 9,610,579 B2
• Filed: 01/06/2015
• Issued: 04/04/2017
• Est. Priority Date: 01/07/2014
• Status: Expired due to Fees

• Current Assignee: Daktari Diagnostics, Inc.
• Original Assignee: Daktari Diagnostics, Inc.
• Inventors: Oppenheimer, Aaron, Weber, Lutz, Kronsbein, Matthias, Traina, Zachary Jarrod, Walker, Philip Charles, Boyce, Andrew, Casey, Adam
• Primary Examiner(s): KWAK, DEAN P
• Application Number:
  US14/590,247
• Publication Number:
  US 20150190802A1
• Time in Patent Office: 819 Days
• Field of Search: 422501-505, 422509, 436180
• CPC Class Codes: B01L 2200/027 for microfluidic devices
• CPC Class Codes: B01L 2300/044 pierceable, e.g. films, membranes
• CPC Class Codes: B01L 2300/0816 Cards, e.g. flat sample carriers usually with flow in two horizontal directions
• CPC Class Codes: B01L 2400/0478 pistons
• CPC Class Codes: B01L 2400/0481 squeezing of channels or chambers
• CPC Class Codes: B01L 2400/0683 mechanically breaking a wall or membrane within a channel or chamber
• CPC Class Codes: B01L 3/502715 characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
• CPC Class Codes: B01L 3/50273 characterised by the means or forces applied to move the fluids micropumps F04B19/006, of the membrane type F04B43/043
• CPC Class Codes: B01L 3/523 with means for closing or opening
• CPC Class Codes: Y10T 137/0318 Processes

Abstract

This document provides devices, systems, and methods for delivering fluids. In some cases, the devices, systems, and methods include a deformable reservoir being at least partially defined by rigid plastically-deformable web. An actuator can press against said rigid plastically-deformable web to plastically deform said web. In some cases, a controller is adapted to receive a cartridge including a deformable reservoir and control the pressing of an actuator against a rigid plastically-deformable web to deliver fluid from the deformable reservoir.

Claims

1. A system for controlled fluid delivery in a microfluidic device comprising:

(a) a cartridge comprising at least one deformable reservoir and at least one microfluidic channel, said deformable reservoir containing a fluid, said deformable reservoir being at least partially defined by deformable web;

(b) an actuator having a pressing surface adapted to press against said deformable web to deform said deformable web; and

(c) a controller adapted to receive said cartridge and to control the actuator'"'"'s pressing of said pressing surface against said deformable web to deliver fluid from the deformable reservoir,

wherein an outer surface of said deformable web and said pressing surface comprise dome-shaped minor images of each other, and wherein a central projecting portion of said pressing surface presses against a central projecting portion of said deformable web to invert said central projecting portion of said deformable web when said cartridge is received in said controller and said actuator is pressed against said deformable reservoir,

wherein a periphery of said deformable reservoir is defined by seals formed by bonds between said deformable web and a second web material, wherein the seals comprise a resilient seal and a breakable seal, wherein the resilient seal is a stronger seal than the breakable seal, and wherein the breakable seal is adapted to break from pressure created within the deformable reservoir when the actuator is pressed against the deformable reservoir, and

wherein said deformable web has a maximum recoil of less than 5% when the deformable web is released after being deformed by said actuator.

2. The system of claim 1, wherein the controller is adapted to control advancement of the actuator against the deformable reservoir in a non-linear manner.

3. The system of claim 1, wherein said outer surface and said pressing surface have radius of curvatures within 10% or less of each other.

4. The system of claim 1, wherein a central axis of said pressing surface is aligned with a central axis of said outer surface when said cartridge is received in said controller and said actuator is pressed against said deformable reservoir.

5. The system of claim 1, wherein said deformable web does not wrinkle when deformed by said actuator.

6. The system of claim 1, wherein the controller is adapted to move the actuator such that said system produces a constant flow into said at least one microfluidic channel.

7. The system of claim 6, wherein the controller is adapted to deliver said fluid at a rate of between 7 μ

l/min and 75 μ

l/min.

8. The system of claim 1, wherein said controller comprises a stepper-motor capable of moving the actuator with micron-level advancement and an encoder to provide feedback to said controller regarding positioning of said actuator.

9. The system of claim 1, wherein said deformable reservoir is bonded to a backbone, said backbone defining a relief area under said breakable seal.

10. The system of claim 1, wherein the breakable seal is adapted to open when a load on said deformable reservoir exceeds 2N, and wherein the resilient seal can withstand loads of at least 35N without breaking.

11. The system of claim 1, wherein said deformable web comprises a metal.

12. The system of claim 11, wherein said metal comprises aluminum.

13. The system of claim 1, wherein said deformable web comprises a polymer.

14. The system of claim 1, wherein said actuator is part of said controller.

15. The system of claim 1, wherein said cartridge comprises two or more deformable reservoirs each containing a differing reagent.

16. The system of claim 1, wherein said cartridge comprises at least one impedance-measurement circuit in said at least one microfluidic channel, said controller being adapted to use said at least one impedance-measurement circuit to determine a location of said fluid in said microfluidic channel.

17. The system of claim 1, wherein said seals further comprises a fill port seal that seals a path for filling the deformable reservoir with the fluid.