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Compositions for RNA interference and methods of use thereof

  • US 9,611,472 B2
  • Filed: 03/20/2014
  • Issued: 04/04/2017
  • Est. Priority Date: 08/07/2002
  • Status: Expired due to Term
First Claim
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1. An isolated, single-stranded small interfering molecule (ss-siRNA) of 19-21 nucleotides in length, wherein the sequence of said ss-siRNA molecule is sufficiently complementary to a target mRNA sequence in a mammalian cell to direct target-specific RNA interference (RNAi) and wherein the 5′

  • nucleotide is 5′

    phosphorylated or is capable of being 5′

    phosphorylated in situ or in vivo with a phosphate group or phosphate group analog, and further wherein the ss-siRNA comprises at least one modified nucleotide.

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