Analyzing a washout period characteristic for psychiatric disorder therapy delivery
First Claim
1. A method comprising:
- with a medical device, delivering therapy to a patient according to a therapy program during a first period, wherein the therapy program defines a value for at least one therapy parameter for managing a psychiatric condition of the patient;
monitoring a physiological signal of the patient during a second period immediately following the first period;
automatically determining a characteristic of a washout period based on the monitored physiological signal, wherein the washout period occurs during the second period, and wherein at least one carryover effect from the therapy substantially dissipates during the washout period;
determining a patient mood state or a mood state probability based on the characteristic of the washout period;
detecting a change in the physiological signal from a baseline state of the physiological signal during the second period; and
determining when the physiological signal returns to the baseline state during the second period, wherein a time period for the physiological signal to return to the baseline state during the second period defines the washout period.
2 Assignments
0 Petitions
Accused Products
Abstract
A characteristic of a washout period following the delivery of therapy to a patient according to a therapy program may be determined based on a physiological parameter of the patient. A washout period includes the period of time during which a carryover effect from the therapy dissipates. The washout period characteristic may include, for example, a duration of the washout period, an amplitude or a trend in a physiological signal during the washout period or a power level or a ratio of power levels in frequency bands of the physiological signal. In some embodiments, washout period characteristics associated with a plurality of therapy programs may be used to compare the programs. In other embodiments, a washout period characteristic may be used to determine a mood state of the patient and, in some cases, modify a therapy program. Monitoring a washout period may also be useful for timing therapy program trials.
-
Citations
42 Claims
-
1. A method comprising:
-
with a medical device, delivering therapy to a patient according to a therapy program during a first period, wherein the therapy program defines a value for at least one therapy parameter for managing a psychiatric condition of the patient; monitoring a physiological signal of the patient during a second period immediately following the first period; automatically determining a characteristic of a washout period based on the monitored physiological signal, wherein the washout period occurs during the second period, and wherein at least one carryover effect from the therapy substantially dissipates during the washout period; determining a patient mood state or a mood state probability based on the characteristic of the washout period; detecting a change in the physiological signal from a baseline state of the physiological signal during the second period; and determining when the physiological signal returns to the baseline state during the second period, wherein a time period for the physiological signal to return to the baseline state during the second period defines the washout period. - View Dependent Claims (2, 3)
-
-
4. A method comprising:
-
with a medical device, delivering therapy to a patient according to a therapy program during a first period, wherein the therapy program defines a value for at least one therapy parameter for managing a psychiatric condition of the patient; monitoring a physiological signal of the patient during a second period immediately following the first period; automatically determining a characteristic of a washout period based on the monitored physiological signal, wherein the washout period occurs during the second period, and wherein at least one carryover effect from the therapy substantially dissipates during the washout period; and determining a patient mood state or a mood state probability based on the characteristic of the washout period, wherein determining a patient mood state or a mood state probability based on the characteristic of the washout period comprises determining the patient mood state based on the characteristic of the washout period by at least comparing the characteristic to a threshold value or comparing the characteristic to a trend template and determining the patient mood state based on the comparison, wherein the threshold value and trend templates are associated with the patient mood state. - View Dependent Claims (5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
-
-
15. A method comprising:
-
delivering therapy to a patient according to a therapy program during a first period; monitoring a physiological signal of the patient during a second period following the first period; receiving information indicative of a patient mood state, wherein the patient mood state occurs during the first or second period; associating the patient mood state with at least one characteristic of the physiological signal during the second period; detecting a change in the physiological signal from a baseline state of the physiological signal during the second period; and determining when the physiological signal returns to the baseline state during the second period, wherein the at least one characteristic of the physiological signal comprises a time period for the physiological signal to return to the baseline state during the second period. - View Dependent Claims (16, 17)
-
-
18. A system comprising:
-
a sensor configured to generate a signal as a function of at least one physiological parameter of a patient; a medical device configured to deliver therapy to a patient according to a therapy program to manage a psychiatric condition during a first period, wherein the therapy program defines a value for at least one therapy parameter; and a processor configured to monitor the signal during a second period immediately following the first period, automatically determine a characteristic of a washout period based on the signal, and determine a mood state or mood state probability based on the characteristic of the washout period, wherein the washout period occurs during the second period, and wherein at least one carryover effect from the therapy substantially dissipates during the washout period, wherein the processor is configured to detect a change in the physiological signal from a baseline state of the physiological signal during the second period, and determine when the physiological signal returns to the baseline state during the second period, wherein a time period for the physiological signal to return to the baseline state during the second period defines the washout period. - View Dependent Claims (19)
-
-
20. A system comprising:
-
a sensor configured to generate a signal as a function of at least one physiological parameter of a patient; a medical device configured to deliver therapy to a patient according to a therapy program to manage a psychiatric condition during a first period, wherein the therapy program defines a value for at least one therapy parameter; and a processor configured to monitor the signal during a second period immediately following the first period, automatically determine a characteristic of a washout period based on the signal, and determine a mood state or mood state probability based on the characteristic of the washout period, wherein the washout period occurs during the second period, and wherein at least one carryover effect from the therapy substantially dissipates during the washout period wherein the processor is configured to determine the patient mood state by at least comparing the characteristic to a threshold value or comparing the characteristic to a trend template and determining the patient mood state based on the comparison, wherein the threshold value and trend templates are associated with the patient mood state. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36)
-
-
37. A system comprising:
-
a sensor configured to generate a signal as a function of at least one physiological parameter of a patient; a medical device configured to deliver therapy to a patient according to a therapy program to manage a psychiatric condition during a first period, wherein the therapy program defines a value for at least one therapy parameter; a processor configured to monitor the signal during a second period immediately following the first period, automatically determine a characteristic of a washout period based on the signal, and determine a first mood state based on the characteristic of the washout period, wherein the washout period occurs during the second period, and wherein at least one carryover effect from the therapy substantially dissipates during the washout period; and a memory, wherein the processor is configured to receive input indicating a second mood state experienced by the patient in response to the delivery of the therapy according to the therapy program, generate a consistency determination based on whether the first and second mood states are consistent, and associate the consistency determination with the therapy program in the memory. - View Dependent Claims (38, 39, 40, 41, 42)
-
Specification