Filling apparatus for drug containers and method for filling the same

• US 9,615,998 B2
• Filed: 12/21/2012
• Issued: 04/11/2017
• Est. Priority Date: 12/23/2011
• Status: Active Grant

• Current Assignee: Jamaleddine Rabih
• Original Assignee: Jamaleddine Rabih
• Inventors: Rabih, Jamaleddine
• Primary Examiner(s): ARNETT, NICOLAS ALLEN
• Application Number:
  US14/368,214
• Publication Number:
  US 20150000784A1
• Time in Patent Office: 1,572 Days
• Field of Search: 141 2, 141 18, 141 21, 141 25- 27
• CPC Class Codes: A61J 1/20 Arrangements for transferring or mixing fluids, e.g. from vial to syringe
• CPC Class Codes: A61J 1/2096 Combination of a vial and a syringe for transferring or mixing their contents
• CPC Class Codes: A61J 1/22 with means for metering the amount of fluid
• CPC Class Codes: A61M 5/1782 Devices aiding filling of syringes in situ combination of a vial and a syringe for transferring or mixing their contents A61J1/2096, filling of medical containers in general B65B3/003
• CPC Class Codes: B65B 3/003 Filling medical containers such as ampoules, vials, syringes or the like
• CPC Class Codes: B65B 31/02 Filling, closing, or filling and closing, containers or wrappers in chambers maintained under vacuum or superatmospheric pressure or containing a special atmosphere, e.g. of inert gas

Abstract

An apparatus for filling drug containers such as syringes, and related filling methods, are disclosed. The apparatus uses a removable pumping syringe mounted to the apparatus and located intermediate between the bulk source of drug and the container (e.g. syringe) to be filled such that the drug is first pumped into the pumping syringe and then pumped into the container (e.g. syringe). Actuation of the intermediate pumping syringe is effected with a linear actuator such as a step motor which is engaged to the plunger of the pumping syringe. The linear actuator is controlled by a controller which typically allows different filling and calibrating procedures.

Claims

1. A filling apparatus for filling a container with a liquid, the apparatus comprising:

a housing supported by a base structure, the base structure comprising a supporting structure configured to releasably support at least one barrel of at least one pumping syringe, the supported structure comprising at least one channel formed into the housing and configured to releasably support the at least one barrel of the at least one pumping syringe;

an actuating member slidingly mounted to the base structure, the actuating member being configured to releasably engage at least one plunger of the at least one pumping syringe;

a linear actuator fixedly mounted to the base structure and drivingly connected to the actuating member for linearly displacing the actuating member, wherein the linear actuator member comprises a step motor driving a thread shaft drivingly engaged to the actuating member such that rotation of the threaded shaft causes the actuating member to slide; and

a controller operatively connected to the linear actuator for controlling the linear actuator according to a predetermined program;

wherein the step motor, the linear actuator and the actuating member are protected by the housing and remain accessible via at least one door providing access to the at least one channel and to the actuating member such as to protect the at least one channel and the actuating member from contaminants;

wherein the at least one door is operatively connected to the controller such that opening the at least one door during will cause the apparatus to stop completely.

2. The filling apparatus as claimed in claim 1, further comprising a receiving structure mounted to the base structure and configured to releasably support connecting tubing.

3. The filling apparatus as claimed in claim 2, wherein the connecting tubing further comprises a dual check valve configured to be fluidly connected to the at least one pumping syringe, and a container connector configured to be fluidly connected to the container.

4. The filling apparatus as claimed in claim 3, wherein the housing comprises a control panel in communication with the controller.

5. The filling apparatus as claimed in claim 3, wherein the actuating member comprises at least one groove to releasably engage at least one free extremity of the at least one plunger of the at least one pumping syringe.

6. The filling apparatus as claimed in any claim 1, wherein the actuating member comprises at least one groove to releasably engage at least one free extremity of the at least one plunger of the at least one pumping syringe.

7. The filling apparatus as claimed in claim 1, wherein the base structure comprises a sliding structure configured to slidingly support the actuating member.

8. The filling apparatus as claimed in claim 7, wherein the sliding structure comprises at least one rod extending between a pair of supporting walls.

9. The filling apparatus as claimed in claim 8, wherein the linear actuator is mounted to one of the supporting walls.

10. The filling apparatus as claimed in claim 9, wherein the sliding structure comprises two rods extending between the pair of supporting walls.

11. The filling apparatus as claimed in claim 8, wherein the sliding structure comprises two rods extending between the pair of supporting walls.

12. The filling apparatus as claimed in claim 1, wherein the housing comprises a control panel in communication with the controller.

13. The filling apparatus as claimed in claim 1, wherein the at least one doors comprises two overlapping first and second doors with the second door overlapping the first door and generally covering an upper half portion of the at least one pumping syringe, including the at least one plunger, such that accidents are prevented and that the plunger remains protected from contaminants.

14. The filling apparatus as claimed in claim 13, wherein the second door is hingedly mounted to the housing, the first door being located under the second door and generally covers the linear actuator, the first door being also hingely mounted to the housing.

15. The filling apparatus as claimed in claim 1, wherein the step motor is configured to rotate by increment of 1.8 degree, which corresponds to a linear displacement of 0.024834 mm per step.

16. A filling apparatus for filling a syringe with a liquid, the apparatus comprising:

a base structure comprising a housing, the housing comprising at least one channel configured to releasably support at least one barrel of at least one pumping syringe;

an actuating member slidingly mounted to the base structure and within the housing, the actuating member being configured to releasably engage at least one plunger of the at least one pumping syringe;

a linear actuator mounted to the base structure and within the housing, the linear actuator being drivingly connected to the actuating member for linearly displacing the actuating member, wherein the linear actuator comprises a step motor driving a threaded shaft drivingly engaged to the actuating member such that rotation of the threaded shaft causes the actuating member to slide; and

a programmable controller operatively connected to the linear actuator for controlling the linear actuator according to a predetermined program;

wherein the housing comprises at least one door providing access to the at least one channel and to the actuating member such as to protect the at least one channel and the actuating member from contaminants, the at least one door being operatively connected to the programmable controller such that opening the at least one door causes the apparatus to stop completely.

17. The filling apparatus as claimed in claim 16, further comprising a receiving structure mounted to the base structure and configured to support connecting tubing.

18. The filling apparatus as claimed in claim 17, wherein the connecting tubing further comprises a dual check valve configured to be fluidly connected to the at least one pumping syringe, and a syringe connector configured to be fluidly connected to the syringe.

19. The filling apparatus as claimed in claim 18, wherein the housing comprises a control panel in communication with the controller.

20. The filling apparatus as claimed in claim 18, wherein the actuating member comprises at least one groove to releasably engage at least one free extremity of the at least one plunger of the at least one pumping syringe.

21. The filling apparatus as claimed in claim 16, wherein the actuating member comprises at least one groove to releasably engage at least one free extremity of the at least one plunger of the at least one pumping syringe.

22. The filling apparatus as claimed in claim 16, wherein the base structure comprises a sliding structure configured to slidingly support the actuating member.

23. The filling apparatus as claimed in claim 22, wherein the sliding structure comprises at least one rod extending between a pair of supporting walls.

24. The filling apparatus as claimed in claim 23, wherein the linear actuator is mounted to one of the pair of supporting walls.

25. The filling apparatus as claimed in claim 24, wherein the sliding structure comprises two rods extending between the pair of supporting walls.

26. The filling apparatus as claimed in claim 23, wherein the sliding structure comprises two rods extending between the pair of supporting walls.

27. The filling apparatus as claimed in claim 16, wherein the housing comprises a control panel in communication with the controller.

28. The filling apparatus as claimed in claim 16, wherein the least one doors comprises two overlapping first and second doors with the second door overlapping the first door, and generally covering an upper half portion of the at least one pumping syringe, including the at least one plunger, such that accidents are prevented and that the plunger remains protected from contaminants.

29. The filling apparatus as claimed in claim 28, wherein the second door is hingedly mounted to the housing, the first door being located under the second door and generally covers the threaded shaft and the step motor, the first door being also hingely mounted to the housing.

30. The filling apparatus as claimed in claim 16, wherein the step motor is configured to rotate by increment of 1.8 degree, which corresponds to a linear displacement of 0.024834 mm per step.