Oral pharmaceutical dosage forms
First Claim
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1. An oral controlled release dosage form comprising a formulation comprising:
- methylphenidate at about 5 to about 30 wt % relative to the total weight of the formulation;
sucrose acetate isobutyrate (SAIB) at about 30 to about 45 wt % relative to the total weight of the formulation;
a rheology modifier at about 2 to about 15 wt % relative to the total weight of the formulation;
a network former at about 2 to about 10 wt % relative to the total weight of the formulation;
a solvent at about 15 to about 40 wt % relative to the total weight of the formulation;
a viscosity enhancing agent at about 0.1 to about 2 wt % relative to the total weight of the formulation; and
a saturated polyglycolized glyceride at about 0.01 to about 5 wt % relative to the total weight of the formulation.
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Abstract
Controlled release oral dosage forms suitable for administration of methylphenidate are provided. Abuse-resistant controlled release oral dosage forms suitable for administration of methylphenidate are also provided. Methods of treating ADD and ADHD using the oral dosage forms are also provided.
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Citations
17 Claims
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1. An oral controlled release dosage form comprising a formulation comprising:
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methylphenidate at about 5 to about 30 wt % relative to the total weight of the formulation; sucrose acetate isobutyrate (SAIB) at about 30 to about 45 wt % relative to the total weight of the formulation; a rheology modifier at about 2 to about 15 wt % relative to the total weight of the formulation; a network former at about 2 to about 10 wt % relative to the total weight of the formulation; a solvent at about 15 to about 40 wt % relative to the total weight of the formulation; a viscosity enhancing agent at about 0.1 to about 2 wt % relative to the total weight of the formulation; and a saturated polyglycolized glyceride at about 0.01 to about 5 wt % relative to the total weight of the formulation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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Specification