Method and system of enhancing removal of toxic anions and organic solutes in sorbent dialysis

• US 9,616,163 B2
• Filed: 12/31/2012
• Issued: 04/11/2017
• Est. Priority Date: 01/04/2012
• Status: Active Grant

• Current Assignee: Fresenius Medical Care Holdings Incorporated (Fresenius Medical Care AG)
• Original Assignee: Fresenius Medical Care Holdings Incorporated (Fresenius Medical Care AG)
• Inventors: Wong, Raymond J., Fontenelle, Lucas
• Primary Examiner(s): Kim, John
• Application Number:
  US14/370,221
• Publication Number:
  US 20150021271A1
• Time in Patent Office: 1,562 Days
• CPC Class Codes: A61M 1/14 Dialysis systems; Artificial kidneys; Blood oxygenators semi-permeable membranes characterised by the material, manufacturing processes therefor B01D71/00 ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
• CPC Class Codes: A61M 1/1696 with dialysate regeneration
• CPC Class Codes: A61M 1/28 Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
• CPC Class Codes: A61M 1/287 Dialysates therefor
• CPC Class Codes: A61M 1/3472 with treatment of the filtrate
• CPC Class Codes: A61M 2202/0496 Urine
• CPC Class Codes: A61M 2209/088 on the body
• CPC Class Codes: B01J 20/0211 Compounds of Ti, Zr, Hf
• CPC Class Codes: B01J 20/0292 Phosphates of compounds other than those provided for in B01J20/048
• CPC Class Codes: B01J 20/06 comprising oxides or hydroxides of metals not provided for in group B01J20/04
• CPC Class Codes: B01J 20/28052 Several layers of identical or different sorbents stacked in a housing, e.g. in a column
• CPC Class Codes: B01J 20/3234 Inorganic material layers
• CPC Class Codes: B01J 2220/42 Materials comprising a mixture of inorganic materials materials coated or impregnated on a carrier B01J20/32
• CPC Class Codes: B01J 2220/62 In a cartridge
• CPC Class Codes: B01J 39/09 Inorganic material
• CPC Class Codes: B01J 39/10 Oxides or hydroxides
• CPC Class Codes: B01J 41/10 Inorganic material
• CPC Class Codes: B01J 41/18 Carbon, coal or tar
• CPC Class Codes: B01J 45/00 Ion-exchange in which a complex or a chelate is formed; Use of material as complex or chelate forming ion-exchangers; Treatment of material for improving the complex or chelate forming ion-exchange properties ion-exchange chromatography processes B01D15/36
• CPC Class Codes: B01J 47/014 in which the adsorbent properties of the ion-exchanger are involved, e.g. recovery of proteins or other high-molecular compounds
• CPC Class Codes: B01J 47/024 : where the ion-exchangers are in a removable cartridge
• CPC Class Codes: B01J 47/026 : using columns or beds of different ion exchange materials in series
• CPC Class Codes: B01J 47/04 : Mixed-bed processes

Abstract

A method of sorbent dialysis is provided for enhanced removal of uremic toxins, such as toxic anions and/or organic solutes, from spent dialysate. More highly adsorbable zirconium polymeric complexes of these anions and/or organic solutes can be initially formed in spent dialysate by treatment with zirconium salt solution or other zirconium cation source, and then removed with adsorbent to provide purified or regenerated dialysate. Sorbent dialysis systems for detoxifying spent dialysate containing toxic anions and organic solutes are also provided.

Claims

1. A method of detoxifying spent dialysate comprising:

(a) providing a first spent dialysate comprising complexable species comprising complexable anions or complexable organic solutes or both;

(b) converting the complexable species in said first spent dialysate to an adsorbable zirconium complex of said species to produce a second spent dialysate comprising said adsorbable zirconium complex of said species;

(c) passing said second spent dialysate through an ion exchange column comprising an ion exchange sorbent effective for adsorbing at least part of said zirconium complex of said species from said second spent dialysate to produce a third spent dialysate having reduced content of said zirconium complex of said species than in said second spent dialysate.

2. The method of claim 1, wherein said adsorbing is performed in the presence of phosphate ions in the second spent dialysate.

3. The method of claim 1, wherein said species are anions.

4. The method of claim 1, wherein said species are sulfate ions, citrate ions, oxalate ions, or phenolate ions, or any combination thereof.

5. The method of claim 1, wherein said species are at least one organic solute.

6. The method of claim 1, wherein said converting of said species in said first spent dialysate to said zirconium complex comprises contacting said first spent dialysate with a zirconium salt solution or cation source.

7. The method of claim 6, wherein said zirconium salt solution or cation source comprises a zirconium carboxylate salt.

8. The method of claim 6, wherein said zirconium salt solution or cation source comprises zirconium acetate.

9. The method of claim 6, wherein said zirconium salt solution or cation source comprises a cation exchange sorbent column comprising zirconium cations through which said first spent dialysate passes.

10. The method of claim 1, wherein said converting of said species in said first spent dialysate to said zirconium complex comprises contacting said first spent dialysate with hydrous zirconium oxide (HZO).

11. The method of claim 6, wherein said zirconium salt solution or cation source comprises a column through which said first spent dialysate is passed, wherein said column comprising hydrous zirconium oxide (HZO), zirconium phosphate (ZrP), or both.

12. The method of claim 6, wherein said converting is performed at a pH of from about 2 to about 7.

13. The method of claim 1, wherein said adsorbing is effective to remove at least about 50% by weight of said zirconium complex of the species in said second spent dialysate.

14. The method of claim 1, wherein said adsorbing is effective to remove from about 50% to about 500% by weight of said zirconium complex of the species in said second spent dialysate.

15. The method of claim 1, wherein said ion exchange column is a cartridge comprising at least one of HZO, alkaline anion-exchange material, activated carbon, or any combinations of these layers.

16. The method of claim 1, wherein said ion exchange column is a cartridge comprising alkaline HZO.

17. The method of claim 1, wherein said ion exchange column is a sorbent cartridge.

18. The method of claim 1, wherein said ion exchange column is incorporated into a wearable artificial kidney.

19. The method of claim 1, wherein a dialyzer is provided in fluid communication with at least one treatment station wherein said first spent dialysate passes from said dialyzer to said at least one treatment station where said converting of said species in said first spent dialysate to said adsorbable zirconium complex is provided to produce said second spent dialysate, and then passing said second spent dialysate through said ion exchange column comprising an ion exchange sorbent, wherein the ion exchange column further being in fluid communication with the dialyzer for recirculating at least a portion of said third spent dialysate thereto.

20. The method of claim 19, wherein said first spent dialysate is spent hemodialysate, spent peritoneal dialysate, or combinations thereof.

21. The method of claim 19, wherein said dialyzer is in fluid communication with blood of a patient.

22. An apparatus for conducting dialysis comprising:

a dialyzer in fluid communication with at least one treatment station for passing a first spent dialysate to said at least one treatment station, wherein said first spent dialysate comprising complexable species comprising complexable anions or complexable organic solutes or both;

said at least one treatment station capable of converting said species in said first spent dialysate to adsorbable zirconium polymeric complex anions to produce a second spent dialysate comprising adsorbable zirconium polymeric complex of the species, and said at least one treatment station in fluid communication with an ion exchange column for transmitting said second spend dialysate to said ion exchange column; and

said ion exchange column comprising an ion exchange sorbent through which said second spent dialysate is passable effective for adsorbing at least part of said zirconium polymeric complex of the species from said second spent dialysate on said ion exchange sorbent to produce a third spent dialysate having reduced content of said zirconium polymeric complex of said species than in said second spent dialysate, and wherein the ion exchange column further being in fluid communication with the dialyzer for recirculating at least a portion of said third spent dialysate thereto.

23. A dialysis system comprising:

a dialyzer in fluid communication with at least one treatment station for passing a first spent dialysate to said first treatment station, wherein said first spent dialysate comprising complexable species comprising at least one of complexable anions and complexable organic solutes;

said at least one treatment station capable of converting said species in said first spent dialysate to adsorbable zirconium polymeric complex anions to produce a second spent dialysate comprising adsorbable zirconium polymeric complex of said species, and said at least one treatment station in fluid communication with a sorbent cartridge for passing the second spent dialysate to said sorbent cartridge;

said sorbent cartridge comprising an ion exchange sorbent through which said second spent dialysate is passable effective for adsorbing at least part of said zirconium polymeric complex of the species from said second spent dialysate to produce a third spent dialysate having reduced content of said zirconium polymeric complex of said species than in said second spent dialysate, wherein the sorbent cartridge further being in fluid communication with the dialyzer for recirculating at least a portion of said third spent dialysate thereto.