Systems and methods of determining injection protocols for diagnostic imaging procedures
First Claim
1. A method of tailoring an injection protocol to an individual patient, the injection protocol to be administered in connection with a diagnostic imaging procedure, the method comprising:
- (a) administering a test injection of a fluid into the individual patient at an administration site thereof, the fluid including a contrast enhancing fluid;
(b) performing a test scan of one or more regions of interest of the individual patient as the fluid propagates therethrough to obtain scan data resulting therefrom;
(c) determining from the scan data an enhancement output from each of the one or more regions of interest at a plurality of points in time as a result of the propagation of the fluid therethrough; and
(d) determining the injection protocol for the individual patient based at least in part upon the enhancement output from each of the one or more regions of interest at each of the plurality of points in time.
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Accused Products
Abstract
A method and system for tailoring an injection protocol to an individual patient, wherein the injection protocol is administered in connection with a diagnostic imaging procedure. The method includes: administering a test injection of a fluid including a contrast enhancing fluid into the patient at an administration site; performing a test scan of one or more regions of interest of the patient as the fluid propagates through the patient to obtain scan data; determining from the scan data an enhancement output from each of the one or more regions of interest at a plurality of points in time as a result of the propagation of the fluid through the patient; and determining the injection protocol for the patient based at least in part upon the enhancement output from each of the one or more regions of interest at each of the plurality of points in time.
384 Citations
22 Claims
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1. A method of tailoring an injection protocol to an individual patient, the injection protocol to be administered in connection with a diagnostic imaging procedure, the method comprising:
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(a) administering a test injection of a fluid into the individual patient at an administration site thereof, the fluid including a contrast enhancing fluid; (b) performing a test scan of one or more regions of interest of the individual patient as the fluid propagates therethrough to obtain scan data resulting therefrom; (c) determining from the scan data an enhancement output from each of the one or more regions of interest at a plurality of points in time as a result of the propagation of the fluid therethrough; and (d) determining the injection protocol for the individual patient based at least in part upon the enhancement output from each of the one or more regions of interest at each of the plurality of points in time. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method of tailoring an injection protocol to an individual patient, the injection protocol to be administered in connection with a diagnostic imaging procedure, the method comprising:
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(a) identifying a patient transfer function for the individual patient based on data specific to the individual patient, the patient transfer function enabling prediction of a desired level of enhancement to be output from each of two or more regions of interest based on a given input; (b) administering a test injection of a fluid into the individual patient at an administration site thereof, the fluid including a contrast enhancing fluid; (c) performing a test scan of the two or more regions of interest of the individual patient as the fluid propagates therethrough to obtain scan data resulting therefrom; (d) determining from the scan data an enhancement output from each of the two or more regions of interest at a plurality of points in time as a result of the propagation of the fluid therethrough; (e) updating the patient transfer function using at least some of the scan data acquired as a result of the test scan; and (f) determining through a numerical optimization technique the given input that, when entered into the patient transfer function, determines the injection protocol for the individual patient with which to generate the desired level of enhancement for each of the two or more regions of interest. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20)
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21. A method of tailoring an injection protocol to an individual patient, the injection protocol to be administered in connection with a diagnostic imaging procedure, the method comprising:
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(a) identifying a patient transfer function for the individual patient based on data specific to the individual patient, the patient transfer function in response to a given input enabling prediction of a desired level of enhancement to be output from each of one or more regions of interest; (b) determining, from scan data acquired as a result of a test scan of the one or more regions of interest while a fluid inclusive of a contrast enhancing fluid therein propagated therethrough, an enhancement level output from each of the one or more regions of interest at a plurality of points in time as a result of the propagation of the fluid therethrough; (c) updating the patient transfer function using at least some of the scan data acquired as a result of the test scan; and (d) determining through a numerical optimization technique the given input that, when entered into the patient transfer function, determines the injection protocol for the individual patient with which to generate the desired level of enhancement for each of the one or more regions of interest.
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22. A system for tailoring an injection protocol to an individual patient, the injection protocol to be administered in connection with a diagnostic imaging procedure, the system comprising:
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(a) a processor for controlling operation of the system; and (b) a programming system operably associated with the processor, the programming system having at least one algorithm for enabling;
(i) use of a patient transfer function determined for the individual patient based on data specific to the individual patient, the patient transfer function in response to a given input enabling prediction of a desired level of enhancement to be output from each of one or more regions of interest;
(ii) input of an enhancement level output from each of the one or more regions of interest at a plurality of points in time, the enhancement levels obtained from scan data acquired during a test scan of the one or more regions of interest while a fluid inclusive of a contrast enhancing fluid therein propagated therethrough;
(iii) updating of the patient transfer function using at least some of the scan data acquired as a result of the test scan; and
(iv) determination through a numerical optimization technique of the given input that, when entered into the patient transfer function, determines the injection protocol for the individual patient with which to generate the desired level of enhancement to be output from each of the one or more regions of interest.
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Specification