Drug delivery implants

• US 9,616,205 B2
• Filed: 08/28/2009
• Issued: 04/11/2017
• Est. Priority Date: 08/13/2008
• Status: Active Grant

• Current Assignee: SMed TA/TD, LLC. (Sites Medical LLC)
• Original Assignee: SMed TA/TD, LLC. (Sites Medical LLC)
• Inventors: Nebosky, Paul S., Zimmerman, Sarah L., Stalcup, Gregory C.
• Primary Examiner(s): Sharma, Yashita
• Assistant Examiner(s): PRESTON, REBECCA STRASZHEIM
• Application Number:
  US12/549,748
• Publication Number:
  US 20100042214A1
• Time in Patent Office: 2,783 Days
• Field of Search: None
• CPC Class Codes: A61B 17/56 Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
• CPC Class Codes: A61B 17/60 for external osteosynthesis, e.g. distractors, contractors
• CPC Class Codes: A61B 17/68 Internal fixation devices , including fasteners and spinal fixators, even if a part thereof projects from the skin bone staples A61B17/0642
• CPC Class Codes: A61B 17/7061 for stabilising vertebrae or discs by improving the condition of their tissues, e.g. using implanted medication or fluid exchange intraosseous injection devices A61B17/3472
• CPC Class Codes: A61B 17/7098 wherein the implant is permeable or has openings, e.g. fenestrated screw hollow surgical screws A61B17/864
• CPC Class Codes: A61B 17/80 Cortical plates , i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates
• CPC Class Codes: A61B 17/846 Nails or pins, i.e. anchors without movable parts, holding by friction only, with or without structured surface A61B17/72, A61B17/86 take precedence
• CPC Class Codes: A61B 17/8625 Shanks, i.e. parts contacting bone tissue
• CPC Class Codes: A61B 17/864 hollow, e.g. with socket or cannulated
• CPC Class Codes: A61B 17/866 Material or manufacture
• CPC Class Codes: A61B 2017/561 Implants with special means for releasing a drug
• CPC Class Codes: A61C 8/0018 characterised by the shape
• CPC Class Codes: A61C 8/0039 in the form of hollow cylinder with an open bottom
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2/30 Joints
• CPC Class Codes: A61F 2/34 Acetabular cups
• CPC Class Codes: A61F 2/36 Femoral heads ; Femoral endoprostheses
• CPC Class Codes: A61F 2/3859 Femoral components
• CPC Class Codes: A61F 2/389 Tibial components A61F2/3868 takes precedence
• CPC Class Codes: A61F 2/40 for shoulders
• CPC Class Codes: A61F 2002/30593 : hollow
• CPC Class Codes: A61F 2002/30672 : temporary
• CPC Class Codes: A61F 2002/30677 : Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
• CPC Class Codes: A61F 2002/3068 : the pharmaceutical product being in a reservoir
• CPC Class Codes: A61F 2002/3071 : Identification means; Administration of patients
• CPC Class Codes: A61F 2002/30784 : Plurality of holes
• CPC Class Codes: A61F 2002/3092 : having an open-celled or open-pored structure
• CPC Class Codes: A61F 2250/0068 : the pharmaceutical product being in a reservoir
• CPC Class Codes: A61F 2250/0089 : coded with symbols, e.g. dots, numbers, letters, words
• CPC Class Codes: A61M 2210/02 : Bones
• CPC Class Codes: A61M 31/002 : Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50
• CPC Class Codes: A61M 5/14276 : specially adapted for implantation

Abstract

An orthopedic implant system includes an orthopedic implant implantable at a selected location within a corporeal body and configured for delivering at least one therapeutic agent to the corporeal body, the implant defining a reservoir and a plurality of channels, the reservoir configured for receiving the at least one therapeutic agent, the plurality of channels configured for conveying the at least one therapeutic agent from the reservoir to a treatment site relative to the corporeal body, the implant being at least one of an internal fixation device and a porous device.

Claims

1. A method of using an orthopaedic implant system, said method comprising the steps of:

providing an orthopaedic implant defining a reservoir, said implant being an internal fixation device, said implant including a threaded section including said reservoir, said internal fixation device being a bone screw including an exterior surface, a head, and said threaded section, said head including a head channel fluidly communicating said reservoir with an exterior surface of said head, said threaded section including at least one threaded section channel, said at least one threaded section channel fluidly communicating said reservoir with said exterior surface of said bone screw, said implant including a continuously tapering inner surface between said head channel and said reservoir, each threaded section channel having an interior diameter and a length which is greater than said interior diameter, a channel diameter of said head channel being respectively larger than a largest interior diameter of each threaded section channel, said channel diameter of said head channel is the same as a large interior diameter of said reservoir;

implanting said implant at a selected location within a corporeal body;

receiving at least one therapeutic agent in said reservoir;

conveying said at least one therapeutic agent from said reservoir to a treatment site relative to said corporeal body via said at least one threaded section channel; and

delivering said at least one therapeutic agent to said corporeal body.

2. The method of claim 1, wherein said at least one threaded section channel fluidly communicates said reservoir with said exterior surface of said bone screw and thereby convey said at least one therapeutic agent from said reservoir to said exterior surface of said bone screw.

3. The method of claim 1, wherein said implant includes only one said reservoir.

4. The method of claim 1, further including refilling said reservoir with said at least one therapeutic agent after said implant has been implanted in said corporeal body.

5. The method of claim 1, further including delivering a plurality of therapeutic agents to said corporeal body via said reservoir and said at least one threaded section channel.

6. The method of claim 1, wherein said reservoir receives said at least one therapeutic agent after said implant has been implanted in said corporeal body and then communicates said at least one therapeutic agent via said at least one threaded section channel to said treatment site.

7. A method of using an orthopaedic implant, said method comprising the steps of:

providing an orthopaedic implant defining a reservoir, said implant including a threaded section, an exterior surface and a head, said threaded section including said reservoir, said head including a head channel fluidly communicating said reservoir with an exterior surface of said head, said threaded section including at least one threaded section channel, said at least one threaded section channel fluidly communicating said reservoir with said exterior surface of said implant, said implant including a continuously tapering inner surface between said head channel and said reservoir, each threaded section channel having an interior diameter and a length which is greater than said interior diameter, a channel diameter of said head channel being respectively larger than a largest interior diameter of each threaded section channel, said channel diameter of said head channel is the same as a large interior diameter of said reservoir;

implanting said implant at a selected location within a corporeal body, said implant being implanted into only soft tissue of said corporeal body;

receiving at least one therapeutic agent in said reservoir;

conveying said at least one therapeutic agent from said reservoir to a treatment site relative to said corporeal body via said at least one threaded section channel; and

delivering said at least one therapeutic agent to said corporeal body.

8. The method of claim 7, wherein said implant is implanted into at least one of a muscle, a ligament, a tendon, a joint capsule, a fibrous tissue, fat, a membrane, and cartilage of said corporeal body.

9. The method of claim 7, wherein the orthopaedic implant is implanted in one of an arm, a hand, a foot, a leg, a hip joint, a knee joint, an ankle joint, a wrist, and a shoulder joint.

10. A method of using an orthopaedic implant system, said method comprising the steps of:

providing an orthopaedic implant defining a reservoir, said implant including a threaded section, an exterior surface and a head, said threaded section including said reservoir, said head including a head channel fluidly communicating said reservoir with an exterior surface of said head, said threaded section including at least one threaded section channel, said at least one threaded section channel fluidly communicating said reservoir with said exterior surface of said implant, said implant including a continuously tapering inner surface between said head channel and said reservoir, each threaded section channel having an interior diameter and a length which is greater than said interior diameter, a channel diameter of said head channel being respectively larger than a largest interior diameter of each threaded section channel, said channel diameter of said head channel is the same as a large interior diameter of said reservoir, said orthopaedic implant being configured for being implanted in a bone and for delivering at least one therapeutic agent at least one of directly within a joint capsule and to said bone;

implanting said implant at a selected location within a corporeal body, said selected location being said bone;

receiving at least one therapeutic agent in said reservoir;

conveying said at least one therapeutic agent from said reservoir to a treatment site relative to said corporeal body via said plurality of channels; and

delivering said at least one therapeutic agent to said corporeal body and thereby delivering said at least one therapeutic agent at least one of directly within said joint capsule and to said bone.