Integrated radiation therapy systems and methods for treating a target in a patient

• US 9,616,248 B2
• Filed: 07/26/2012
• Issued: 04/11/2017
• Est. Priority Date: 06/05/2002
• Status: Expired due to Fees

• Current Assignee: Varian Medical Systems Incorporated (Siemens AG)
• Original Assignee: Varian Medical Systems Incorporated (Siemens AG)
• Inventors: Meier, Eric, Mate, Timothy P., Wright, J. Nelson, Dimmer, Steven C., Purdy, Lynn M.
• Primary Examiner(s): Brutus, Joel F
• Application Number:
  US13/559,518
• Publication Number:
  US 20130172657A1
• Time in Patent Office: 1,720 Days
• Field of Search: 600427
• CPC Class Codes: A61N 2005/1051 using an active marker markers in general A61B90/39
• CPC Class Codes: A61N 5/1039 using functional images, e.g. PET or MRI
• CPC Class Codes: A61N 5/1049 for verifying the position of the patient with respect to the radiation beam
• CPC Class Codes: A61N 5/1067 in real time, i.e. during treatment
• CPC Class Codes: A61N 5/107 in real time, i.e. during treatment

Abstract

An integrated radiation therapy process comprises acquiring first objective target data related to a parameter of a target within a patient by periodically locating a marker positioned within the patient using a localization modality. This method continues with obtaining second objective target data related to the parameter of the target by periodically locating the marker. The first objective target data can be acquired in a first area that is apart from a second area which contains a radiation delivery device for producing an ionizing radiation beam for treating the patient. The localization modality can be the same in both the first and second areas. In other embodiments, the first objective target data can be acquired using a first localization modality that uses a first energy type to identify the marker and the second objective target data can be obtained using a second localization modality that uses a second energy.

Claims

1. A method for treating a target in a patient with an ionizing radiation beam, wherein a marker is positioned within the patient relative to the target, the method comprising:

acquiring first target data by locating the marker in a first reference frame external to the patient using a portable localization unit having a marker localization modality and while the patient and the portable localization system are positioned at a treatment planning area;

obtaining second target data by locating the marker in a second reference frame of a radiation delivery device via the portable localization unit while irradiating the patient with an ionizing radiation beam of the radiation delivery device according to a radiation treatment plan, and while the patient is positioned at a radiation delivery area, wherein the radiation delivery area is at a location that is separate from the treatment planning area;

acquiring hardware data related to the radiation delivery device; and

at least one of—

aligning a position of the patient at the radiation delivery area using the second target data and according to the first target data, and

adjusting the radiation treatment plan using the first target data, the second target data, and the hardware data.

2. The method of claim 1, further comprising simulating treatment using the first target data.

3. The method of claim 1, further comprising simulating the radiation treatment plan using the first target data and evaluating the radiation treatment plan using the second target data and the hardware data.

4. The method of claim 1, further comprising providing the first target data, the second target data, and the hardware data to an information management system.

5. The method of claim 1 wherein the localization modality comprises determining locations of the marker using a non-ionizing energy.

6. The method of claim 5 wherein the marker comprises a magnetic transponder that wirelessly transmits a location signal in response to a wirelessly transmitted excitation energy.

7. The method of claim 1, wherein developing the radiation treatment plan includes adapting a previous treatment plan based on at least one of the first target data, the second target data, and the hardware data.

9. The method of claim 1, further comprising (a) retrieving the first target data and the second target data from a memory device and (b) monitoring a size and shape of the target based on the first and second target data.

10. The method of claim 1, further comprising (a) retrieving the first target data and the second target data from a memory device and (b) monitoring a trajectory of the target based on the first and second target data.

11. The method of claim 1, further comprising correlating the second target data with hardware data related to the ionizing radiation beam at corresponding time intervals of the irradiating procedure.

12. The method of claim 1, further comprising positioning the patient with respect to a radiation delivery device in a radiation vault during a setup stage so that the target is located at a targeted location relative to a machine isocenter of the radiation delivery device using the second target data.

13. The method of claim 12, further comprising locating the marker in a reference frame external to the patient while a human technician is in the radiation vault along with the patient.

14. The method of claim 13 wherein the marker has a magnetic transponder, and wherein locating the marker in the reference frame of the radiation delivery device comprises:

wirelessly transmitting excitation energy to the marker;

wirelessly transmitting location signals from the magnetic transponder of the marker to a sensor array external of the patient;

sensing the location signals from the marker; and

periodically calculating the location of the marker in the reference frame of the radiation delivery device based on one or more sensed location signals.

8. The method of 1, further comprising (a) obtaining images of the target and of the marker and (b) determining coordinates of the marker and the target in a reference frame external to the patient before acquiring the first target data.

15. A method for providing integrated radiation therapy, comprising:

acquiring first objective target data related to a parameter of a target within a patient by autonomously locating a marker positioned within the patient with respect to a first external frame using a first localization unit located in a first area, wherein the first area is apart from a second area that contains a radiation delivery device which produces an ionizing radiation beam for treating the patient;

using the first objective target data to develop a radiation treatment plan for treating the target with ionizing radiation;

irradiating the patient via the radiation delivery device according to the radiation treatment plan;

obtaining second objective target data related to the parameter of the target by autonomously locating the marker with respect to a second external frame of the radiation delivery device using a second localization unit in the second area;

irradiating the patient with an ionizing radiation beam of the radiation delivery device while obtaining the second objective target data; and

adapting the radiation treatment plan based on the second objective target data.

16. The method of claim 15 wherein the localization modality that periodically locates the marker for both the first objective target data and the second objective target data uses a non-ionizing energy.

17. The method of claim 16 wherein the marker comprises a magnetic transponder that wirelessly transmits a location signal in response to a wirelessly transmitted excitation energy.

18. The method of claim 16, further comprising (a) obtaining images of the target and of the marker and (b) determining coordinates of the marker and the target in a reference frame before acquiring the first objective target data.

19. The method of claim 16, further comprising (a) retrieving the first objective target data and the second objective target data from a memory device and (b) monitoring a size and shape of the target by evaluating differences between the first objective target data and the second objective target data.

20. The method of claim 16, further comprising (a) retrieving the first objective target data and the second objective target data from a memory device and (b) comparing a trajectory of the target using the first objective target data and the second objective target data.

21. The method of claim 16, further comprising (a) irradiating the target while obtaining the second objective target data and (b) correlating the second objective target data with hardware data related to a parameter of a radiation delivery device at corresponding time intervals.

22. The method of claim 16, further comprising positioning the patient with respect to a radiation delivery device in a radiation vault during a setup stage so that the target is located at a targeted location relative to a machine isocenter of the radiation delivery device using the second objective target data.

23. The method of claim 22, further comprising locating the marker in a reference frame of the radiation delivery device while a human technician is in the radiation vault along with the patient.

24. The method of claim 23 wherein the marker has a magnetic transponder, and wherein locating the marker in the reference frame of the radiation delivery device comprises:

wirelessly transmitting excitation energy to the marker to energized the magnetic transponder;

wirelessly transmitting location signals from the magnetic transponder of the marker to a sensor array external of the patient;

sensing the location signals of the marker; and

periodically calculating the location of the marker in the reference frame of the radiation delivery device based on one or more of the sensed.

25. An integrated radiation therapy process, comprising:

acquiring first objective target data related to a parameter of a target within a patient by periodically locating a marker positioned within the patient with respect to a first reference frame using a first localization unit located at a treatment planning area;

positioning the patient with respect to a radiation delivery device in a radiation vault separate from the treatment planning area and such that the target is located at a desired location relative to a second reference frame associated with a machine isocenter of the radiation delivery device;

obtaining second objective target data related to the parameter of the target by periodically locating the marker relative to the second reference frame and using a second localization unit at the radiation vault and separate from the first localization unit;

irradiating the target with an ionizing radiation beam of the radiation delivery device while obtaining the second objective target data; and

aligning a position of the patient using the second target data and according to the first objective target data.

26. The method of claim 25, further comprising (a) irradiating the target while obtaining the second objective target data and (b) correlating the second objective target data with hardware data related to a parameter of a radiation delivery device at corresponding time intervals.

27. The method of claim 25 wherein the marker has a magnetic transponder, and wherein locating the marker in the second reference frame associated with the machine isocenter of the radiation delivery device comprises:

wirelessly transmitting excitation energy to the marker to energized the magnetic transponder;

wirelessly transmitting location signals from the magnetic transponder of the marker to a sensor array external of the patient;

sensing the location signals of the marker; and

periodically calculating the location of the marker in the second reference frame of the radiation delivery device based on one or more sensed location signals.

28. A method of integrated radiation therapy, comprising:

acquiring objective planning data related to a parameter of a target within a patient by periodically locating a marker positioned within the patient with respect to a first external frame via a localization unit having a localization modality, wherein the localization unit is in a in a first area separate from a second area containing a radiation delivery device that produces a radiation beam;

obtaining objective in-situ data related to the parameter of the target using the localization unit at the second area to periodically locate the marker while the patient is located at the second area, wherein obtaining the objective in-situ data includes obtaining the objective in-situ data with respect to a second external frame associated with the radiation delivery device;

irradiating the target with a radiation beam of the radiation delivery device while obtaining the in-situ data; and

determining a parameter of radiation delivered to the patient using the objective in-situ data.

29. The method of claim 28 wherein the localization modality that periodically locates the marker for both the objective planning data and the objective in-situ data uses a non-ionizing energy.

30. The method of claim 28, further comprising (a) irradiating the target while obtaining the objective in-situ data and (b) correlating the objective in-situ data with hardware data related to a parameter of a radiation delivery device at corresponding time intervals.

31. A method of integrated radiation therapy, comprising:

performing a treatment planning procedure by (a) obtaining images of a target within a patient and of a marker positioned within the patient proximate to the target using an imaging modality, (b) acquiring first target data by periodically locating the marker with respect to a first reference frame external to the patient using a localization modality, and (c) developing a treatment plan using the images and the first target data;

performing a setup procedure by (a) obtaining second target data via periodically locating the marker with respect to a second reference from associated machine isocenter of a radiation delivery device in a radiation vault containing the radiation delivery device using the localization modality, and (b) moving the patient to align the target relative to the machine isocenter based on the second target data;

performing a radiation treatment fraction by irradiating the patient according to the treatment plan while obtaining the second target data using the localization modality; and

adjusting the radiation treatment fraction based on the second target data.

32. The method of claim 31 wherein the localization modality uses a non-ionizing energy.

33. The method of claim 31, further comprising controlling the radiation delivery device while irradiating the target based on the second objective target data.

34. The method of claim 31, further comprising (a) irradiating the target while obtaining the second objective target data and (b) correlating the second objective target data with hardware data related to a parameter of a radiation delivery device at corresponding time intervals.