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Chiral nucleic acid adjuvant

  • US 9,617,547 B2
  • Filed: 07/12/2013
  • Issued: 04/11/2017
  • Est. Priority Date: 07/13/2012
  • Status: Active Grant
First Claim
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1. An oligonucleotide which comprises two to four sequences each represented by 5′

  • -X1X2CpGX3X4-3′ and

    has a length of 14 to 32 nucleotides,wherein the CpG is non-methylated CpG without a modified phosphate backbone,wherein X1X2 is AA, AT, GA, or GT, and contains no modified phosphate backbones,wherein X3X4 is TT, AT, AC, TC, or CG, and contains no modified phosphate backbones, andthe oligonucleotide comprises at least one modified phosphate backbone at a site other than the parts represented by 5′

    -X1X2CpGX3X4-3′

    .

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