Ophthalmic lenses with oxygen-generating elements therein
First Claim
1. A contact lens, comprising:
- (1) a lens body composed of a silicone hydrogel material;
(2) at least one anode for electrolytically generating oxygen from water in contact with the anode;
(3) at least one cathode operatively coupled with said at least one anode to form an electrolytic cell;
(4) a power source; and
(5) a control element,wherein the anode, the cathode, the power source, and the control element are embedded within the lens body and operatively connected to each other,wherein the power source comprises at least one battery,wherein the control element is capable of automatically applying a potential voltage between the anode and the cathode and driving an electrical current through the anode and the cathode to generate oxygen from electrolysis of water, and controlling the timing and duration of electrolysis of water when the contact lens is worn by a patient,wherein the contact lens has an anterior surface and an opposite posterior surface and a circumferential edge where the anterior and posterior surfaces are tapered off,wherein the contact lens comprises a central optical zone, a peripheral zone surrounding the central optical zone, and an edge zone surrounding the peripheral zone,wherein the anode and the cathode independently of each other have a shape of a flat annular ring which is concentric with the center of the contact lens and has a substantially even exterior peripheral edge having a diameter of from about 8 mm to about 14 mm and a width of from about 0.5 mm to about 2.5 mm,wherein the anode and the cathode have an opaque color and partially or completely overly the lens wearer'"'"'s limbus area when the contact lens is on-eye and centered, provided that the innermost border or edge, closest to the geometric center of the lens, of the flat annular ring is about 5 mm to about 12 mm from the geometric center of the contact lens.
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Accused Products
Abstract
Described herein is a contact lens which can actively generate oxygen that is directly supplied to the cornea when it is worn by a patient. The contact lens comprises: a lens body composed of a hydrogel material or preferably a silicone hydrogel material; at least one anode for electrolytically generating oxygen from water in contact with the anode; and at least one cathode operatively coupled with the anode to form an electrolytic cell. The anode and the cathode are embedded within the lens body and operatively connected to a power source and to a control element which automatically applies a potential voltage between the anode and the cathode, drives an electrical current through the anode and the cathode to generate oxygen from electrolysis of water, and controls the timing and duration of electrolysis of water in the eye.
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Citations
20 Claims
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1. A contact lens, comprising:
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(1) a lens body composed of a silicone hydrogel material; (2) at least one anode for electrolytically generating oxygen from water in contact with the anode; (3) at least one cathode operatively coupled with said at least one anode to form an electrolytic cell; (4) a power source; and (5) a control element, wherein the anode, the cathode, the power source, and the control element are embedded within the lens body and operatively connected to each other, wherein the power source comprises at least one battery, wherein the control element is capable of automatically applying a potential voltage between the anode and the cathode and driving an electrical current through the anode and the cathode to generate oxygen from electrolysis of water, and controlling the timing and duration of electrolysis of water when the contact lens is worn by a patient, wherein the contact lens has an anterior surface and an opposite posterior surface and a circumferential edge where the anterior and posterior surfaces are tapered off, wherein the contact lens comprises a central optical zone, a peripheral zone surrounding the central optical zone, and an edge zone surrounding the peripheral zone, wherein the anode and the cathode independently of each other have a shape of a flat annular ring which is concentric with the center of the contact lens and has a substantially even exterior peripheral edge having a diameter of from about 8 mm to about 14 mm and a width of from about 0.5 mm to about 2.5 mm, wherein the anode and the cathode have an opaque color and partially or completely overly the lens wearer'"'"'s limbus area when the contact lens is on-eye and centered, provided that the innermost border or edge, closest to the geometric center of the lens, of the flat annular ring is about 5 mm to about 12 mm from the geometric center of the contact lens. - View Dependent Claims (2)
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3. A contact lens, comprising:
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(1) a lens body composed of a silicone hydrogel material; (2) a coating on the lens body, wherein the coating is a hydrogel layer having a higher water content and a thickness of at least about 0.05 micrometers as measured with atomic force microscopy across a cross section from the posterior surface to the anterior surface of the silicone hydrogel contact lens in fully hydrated state and being substantially free of silicone; (3) at least one anode for electrolytically generating oxygen from water in contact with the anode; (4) at least one cathode operatively coupled with said at least one anode to form an electrolytic cell; (5) a power source; and (6) a control element, wherein the anode, the cathode, the power source, and the control element are embedded within the lens body and operatively connected to each other, wherein the power source comprises at least one battery, wherein the control element is capable of automatically applying a potential voltage between the anode and the cathode and driving an electrical current through the anode and the cathode to generate oxygen from electrolysis of water, and controlling the timing and duration of electrolysis of water when the contact lens is worn by a patient, wherein the contact lens has an anterior surface and an opposite posterior surface and a circumferential edge where the anterior and posterior surfaces are tapered off, wherein the contact lens comprises a central optical zone, a peripheral zone surrounding the central optical zone, and an edge zone surrounding the peripheral zone. - View Dependent Claims (4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method for producing a contact lens, comprising the steps of:
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(1) obtaining a mold which comprises one female mold half and one male mold half, wherein the female mold half defines a first molding (or optical) surface which corresponds to the anterior surface of a contact lens and the second mold half defines a second molding (or optical) surface which corresponds to the posterior surface of the contact lens, wherein the female and male mold halves are configured to receive each other such that a lens forming cavity is formed between the first molding surface and the second molding surface when being closed; (2) deposing a first amount of a lens formulation onto the first molding surface of the female mold half to form a first layer with a desired thickness; (3) optionally curing the first layer of the lens formulation on the first molding surface of the female mold half; (4) placing at least one anode for electrolytically generating oxygen, at least one cathode operatively coupled with said at least one anode to form an electrolytic cell, a control element, and a power source on top of the first layer of the lens formulation which is optionally cured, wherein the power source comprises at least one battery, wherein the control element is capable of automatically applying a potential voltage between the anode and the cathode and driving an electrical current through the anode and the cathode to generate oxygen from electrolysis of water, and controlling the timing and duration of electrolysis of water when the contact lens is worn by a patient; (5) deposing a second amount of the lens formulation over the first layer, the anode, the cathode, the control element, and the power source to form a second layer of the lens formulation, wherein the anode, the cathode, the control element, and the power source are sandwiched between the first and second layers of the lens formulation; (6) closing the male mold half onto the female mold half to enclose the anode, the cathode, the control element, and the power source sandwiched between the first and second layers of the lens formulation within the lens-forming cavity formed between the first and second molding surfaces; (7) curing thermally or actinically the first and second layers of the lens formulation within the lens-forming cavity to form the contact lens. - View Dependent Claims (19, 20)
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Specification