Systems and methods for identifying unknown drug targets via adverse event data
First Claim
1. A method for identifying unknown drug targets via adverse event data, comprising:
- receiving, by an analyzer module executed by a processor of a computing device from a user, an identification of a first drug having one or more unknown target proteins;
identifying, by the analyzer module from a medication information database stored in a computer-readable storage medium, a second drug related to the first drug;
retrieving, by the analyzer module from an adverse event database stored in the computer-readable storage medium, a first side effect profile associated with the first drug, and a second side effect profile associated with the second drug;
generating, by the analyzer module, a third side effect profile comprising a subset of the first side effect profile not shared by the second side effect profile;
identifying, by the analyzer module from the adverse event database, a third drug having a fourth side effect profile comprising the third side effect profile;
retrieving, by the analyzer module from the medication information database, a list of one or more target proteins of the third drug not targeted by the second drug; and
presenting, by the analyzer module via a display interface of the computing device to the user, the retrieved list of one or more target proteins as potential target proteins of the first drug.
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Accused Products
Abstract
The present disclosure is directed to systems and methods for identifying unknown drug targets via adverse event data. An analyzer receives an identification of a first drug having one or more unknown target proteins and identifies a second drug related to the first drug. The analyzer retrieves, from an adverse event database, a first side effect profile associated with the first drug, and a second side effect profile associated with the second drug. The analyzer generates a third side effect profile comprising a subset of the first side effect profile not shared by the second side effect profile, and identifies a third drug having a fourth side effect profile comprising the third side effect profile. The analyzer retrieves a list of one or more target proteins of the third drug not targeted by the second drug, and presents the retrieved list as potential target proteins of the first drug.
22 Citations
18 Claims
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1. A method for identifying unknown drug targets via adverse event data, comprising:
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receiving, by an analyzer module executed by a processor of a computing device from a user, an identification of a first drug having one or more unknown target proteins; identifying, by the analyzer module from a medication information database stored in a computer-readable storage medium, a second drug related to the first drug; retrieving, by the analyzer module from an adverse event database stored in the computer-readable storage medium, a first side effect profile associated with the first drug, and a second side effect profile associated with the second drug; generating, by the analyzer module, a third side effect profile comprising a subset of the first side effect profile not shared by the second side effect profile; identifying, by the analyzer module from the adverse event database, a third drug having a fourth side effect profile comprising the third side effect profile; retrieving, by the analyzer module from the medication information database, a list of one or more target proteins of the third drug not targeted by the second drug; and presenting, by the analyzer module via a display interface of the computing device to the user, the retrieved list of one or more target proteins as potential target proteins of the first drug. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A system for identifying unknown drug targets via adverse event data, comprising:
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a computing device, in communication with a computer-readable storage medium comprising an adverse event database and a medication information database, comprising a display interface and a processor executing an analyzer module configured for; receiving, from a user, an identification of a first drug having one or more unknown target proteins; identifying, from the medication information database, a second drug related to the first drug; retrieving, from the adverse event database, a first side effect profile associated with the first drug, and a second side effect profile associated with the second drug; generating a third side effect profile comprising a subset of the first side effect profile not shared by the second side effect profile; identifying, from the adverse event database, a third drug having a fourth side effect profile comprising the third side effect profile; retrieving, from the medication information database, a list of one or more target proteins of the third drug not targeted by the second drug; and presenting, via the display interface to the user, the retrieved list of one or more target proteins as potential target proteins of the first drug. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18)
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Specification