Optical coherence tomography (OCT) imaging systems having adaptable lens systems and related methods and computer program products

• US 9,622,658 B2
• Filed: 06/11/2014
• Issued: 04/18/2017
• Est. Priority Date: 04/24/2008
• Status: Active Grant

• Current Assignee: Leica Microsystems NC, Inc. (Danaher Corporation)
• Original Assignee: Bioptigen, Inc. (Danaher Corporation)
• Inventors: Hart, Robert H., Buckland, Eric L., Myers, Glenn A., Izatt, Joseph A., Vance, Joseph Elliott
• Primary Examiner(s): SAHLE, MAHIDERE S
• Application Number:
  US14/301,670
• Publication Number:
  US 20140293223A1
• Time in Patent Office: 1,042 Days
• Field of Search: 351200-247
• CPC Class Codes: A61B 3/102 for optical coherence tomography [OCT]
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/0073 by tomography, i.e. reconstruction of 3D images from 2D projections A61B5/0066 takes precedence
• CPC Class Codes: G02B 26/105 with one or more pivoting mirrors or galvano-mirrors G02B26/101 takes precedence

Abstract

OCT imaging systems are provided for imaging a spherical-type eye including a source having an associated source arm path and a reference arm having an associated reference arm path coupled to the source path. The reference arm path has an associated reference arm path length. A sample is also provided having an associated sample arm path coupled to the source arm and reference arm paths. A lens having a focal power optimized for a diameter of the spherical-type eye is provided along with a reference arm path length adjustment module coupled to the reference arm. The reference arm path length adjustment module is configured to automatically adjust the reference arm path length such that the reference arm path length is based on an eye diameter of the subject.

Claims

1. An optical coherence tomography (OCT) imaging system for imaging structures adjacent a posterior surface of a substantially spherical ball-lens device, the system comprising:

a source having an associated source arm path;

a reference arm having an associated reference arm path coupled to the source arm path, the reference arm path having an associated reference arm path length;

a sample arm having an associated sample arm path coupled to the source arm path, the sample arm comprising an input optical fiber delivering optical radiation from the source, at least one optical element following the input optical fiber, at least one scanning mirror following the at least one optical element, at least one optical element following the at least one scanning mirror, and the substantially spherical ball lens device following the at least one optical element;

a non-zero working distance between the at least one optical element and the substantially spherical ball lens device; and

a reference arm path length adjustment module coupled to the reference arm,

wherein the working distance between the at least one optical element and the substantially spherical ball lens device are configured to adjust such that a conjugate of the at least one scanning mirror is imaged interior to the substantially spherical ball lens device, posterior to the anterior surface of the substantially spherical ball lens device and anterior to the posterior surface of the substantially spherical ball lens device; and

wherein the optical radiation from the input optical fiber is focused to an intermediate conjugate anterior to the substantially spherical ball lens device, wherefrom the intermediate conjugate of the optical radiation from the input optical fiber is focused to a region posterior to the image of the at least one scanning mirror and to a region adjacent the posterior surface of the substantially spherical ball lens device.

2. The OCT imaging system of claim 1, wherein the reference arm is adjusted in coordination with the working distance to position an OCT image of the region adjacent the posterior surface of the substantially spherical ball lens device within a Fourier domain imaging window.

3. The OCT imaging system of claim 1, wherein the optical radiation from the input optical fiber is focused to a substantially telecentric intermediate conjugate.

4. The OCT imaging system of claim 1:

wherein the at least one optical element within the sample arm has adjustable optical focusing power; and

wherein the adjustable optical focusing power is controlled to adjust the position of focus relative to the posterior surface of the substantially spherical ball lens device.

5. The OCT imaging system of claim 4:

wherein the at least one optical element within the sample arm has adjustable optical focusing power; and

wherein the adjustable optical focusing power is controlled to adjust the position of focus relative to the posterior surface of the substantially spherical ball lens device dependent on the diameter of the substantially spherical ball lens device.

6. The OCT imaging system of claim 1:

wherein the at least one optical element within the sample arm comprises at least one interchangeable element configured to adjust optical focusing power; and

wherein the at least one interchangeable element is selected to adjust the position of focus relative to the posterior surface of the substantially spherical ball lens device dependent on the diameter of the substantially spherical ball lens device.

7. The OCT imaging system of claim 1, wherein the substantially spherical ball lens device is a distal optical element in the sample arm of the OCT imaging system.

8. The OCT imaging system of claim 7:

wherein the sample arm with the substantially spherical ball lens device is positioned proximate a subject under test; and

wherein the structures adjacent the posterior surface of the substantially spherical ball lens device include the subject under test.

9. The OCT imaging system of claim 1, wherein the substantially spherical ball lens device is an element physically separate from the sample arm of the OCT imaging system.

10. The OCT imaging system of claim 9:

wherein the substantially spherical ball lens device is proximate a subject under test; and

wherein the structures adjacent the posterior surface of the substantially spherical ball device lens include the subject under test.

11. The OCT imaging system of claim 9, wherein the substantially spherical ball lens device is the subject under test.

12. A method for imaging structures adjacent a posterior surface of a substantially spherical ball lens device using a scanning optical coherence tomography (OCT) imaging system, the method comprising:

positioning a substantially spherical ball lens device distal to sample arm optics of the scanning OCT imaging system;

adjusting a working distance between the distal sample arm optical element and an anterior surface of the substantially spherical ball lens device such that a conjugate of at least one scanning mirror is imaged within the interior of the substantially spherical ball lens device, posterior to the anterior surface of the substantially spherical ball lens device and anterior to the posterior surface of the substantially spherical ball lens device, such that a scanning beam pivots around a region interior to the substantially spherical ball lens device; and

focusing optical radiation emanating from a distal end of an optical fiber terminating in the sample arm to a region posterior to a position of the conjugate of the at least one scanning mirror and to a region adjacent the posterior surface of the substantially spherical ball lens device.

13. A computer program product for imaging structures adjacent a posterior surface of a substantially spherical ball lens device using a scanning optical coherence tomography (OCT) system, the computer program product comprising:

a non-transitory computer readable storage medium having computer readable program code embodied in said medium, the computer readable program code comprising;

computer readable program code configured to image structures adjacent the posterior surface of a substantially spherical ball lens device using optics positioned between at least one scanning mirror and the substantially spherical ball lens device, wherein the optics image are configured to image conjugate of the at least one scanning mirror to a region internal to the substantially spherical ball lens device and focus a light source posterior to the image of the at least one scanning mirror and to a region adjacent the posterior surface of the substantially spherical ball lens device; and

computer readable program code configured to process an optical coherence tomography image of a region adjacent the posterior surface of the substantially spherical ball lens device.