Pharmaceutical composition containing lutein and antioxidant for treating and preventing human disease

• US 9,622,970 B2
• Filed: 05/08/2014
• Issued: 04/18/2017
• Est. Priority Date: 05/08/2014
• Status: Active Grant

• Current Assignee: Yaguang Liu
• Original Assignee: Yaguang Liu
• Inventors: Liu, Yaguang
• Primary Examiner(s): Krass, Frederick
• Assistant Examiner(s): HEYES, AMANDA E
• Application Number:
  US14/120,219
• Publication Number:
  US 20150320699A1
• Time in Patent Office: 1,076 Days
• CPC Class Codes: A61K 31/047 having two or more hydroxy groups, e.g. sorbitol
• CPC Class Codes: A61K 31/122 having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
• CPC Class Codes: A61K 47/42 Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein oligopeptides having up to five amino acids A61K47/183; polyamino acids A61K47/34
• CPC Class Codes: A61K 9/0053 Mouth and digestive tract, i.e. intraoral and peroral administration rectal administration A61K9/0031
• CPC Class Codes: A61K 9/107 Emulsions ; Emulsion preconcentrates; Micelles composition of emulsions A61K47/00
• CPC Class Codes: A61K 9/127 Liposomes
• CPC Class Codes: A61K 9/1272 with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids with cholesterol as the only non-phosphatidyl surfactant A61K9/127; lipids as modifying agent A61K47/543
• CPC Class Codes: A61K 9/5047 Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
• CPC Class Codes: A61K 9/5078 with drug-free core

Abstract

The present invention is to providing a new preparation including complex of a medical compound with lutein, astaxanthin and antioxidant. The new preparation includes stabilized liposome preparation, sustained release preparation and polymeric micelles preparation which used as delivery systems for lutein, astaxanthin and antioxidant. The new preparation significantly increases bioavailability of lutein and astaxanthin and uses for treatment and prevention of eyes and other disease.

Claims

1. A pharmaceutical preparation for increasing bioavailability and solubility of lutein, comprising an effective amount of polymeric micelles containing lutein, which have been made by self-assembling soy polypeptide and Hadai extract having a molecular weight of about 240,000 and dehydrating in an ethanol/water mixture.