Pen-type injector

• US 9,623,190 B2
• Filed: 06/13/2016
• Issued: 04/18/2017
• Est. Priority Date: 03/03/2003
• Status: Active Grant

• Current Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Original Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Inventors: Veasey, Robert Frederick, Perkins, Robert, Plumptre, David Aubrey
• Primary Examiner(s): MENDEZ, MANUEL A
• Application Number:
  US15/180,148
• Publication Number:
  US 20160296708A1
• Time in Patent Office: 309 Days
• Field of Search: 604208-211, 128DIG 1, 128DIG 12, 128DIG 13
• CPC Class Codes: A61M 2005/2407 from the rear
• CPC Class Codes: A61M 2005/3126 Specific display means related to dosing
• CPC Class Codes: A61M 2205/581 by audible feedback
• CPC Class Codes: A61M 2205/582 by tactile feedback
• CPC Class Codes: A61M 5/24 Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/31528 by means of rotational movements, e.g. screw-thread mechanisms
• CPC Class Codes: A61M 5/31533 Dosing mechanisms, i.e. setting a dose administrating mechanisms A61M5/31565
• CPC Class Codes: A61M 5/31535 Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
• CPC Class Codes: A61M 5/31536 Blocking means to immobilize a selected dose, e.g. to administer equal doses
• CPC Class Codes: A61M 5/31541 Means preventing setting of a dose beyond the amount remaining in the cartridge
• CPC Class Codes: A61M 5/31546 Electrically operated dose setting, e.g. input via touch screen or plus/minus buttons
• CPC Class Codes: A61M 5/31551 including axial movement of dose setting member
• CPC Class Codes: A61M 5/3156 using volume steps only adjustable in discrete intervals, i.e. individually distinct intervals
• CPC Class Codes: A61M 5/31563 interacting with a displaceable stop member
• CPC Class Codes: A61M 5/31565 Administration mechanisms, i.e. constructional features, modes of administering a dose dosing mechanisms for setting a dose A61M5/31533
• CPC Class Codes: A61M 5/31568 Means keeping track of the total dose administered, e.g. since the cartridge was inserted
• CPC Class Codes: A61M 5/3157 Means providing feedback signals when administration is completed A61M5/20 takes precedence
• CPC Class Codes: A61M 5/31575 using scaling up or down transmissions, e.g. gearbox
• CPC Class Codes: A61M 5/31578 based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
• CPC Class Codes: A61M 5/31585 performed by axially moving actuator, e.g. an injection button
• CPC Class Codes: A61M 5/31593 : Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
• CPC Class Codes: A61M 5/32 : Needles; Details of needles pertaining to their connection with syringe or hub infusion needles A61M5/158; Accessories for bringing the needle into, or holding the needle on, the body A61M5/42, A61M5/46 take precedence; guide needles for catheters A61M25/065; Devices for protection of needles apparatus specially adapted for cleaning or sterilising needles A61M5/001

Abstract

The present invention relates to injectors, such as pen-type injectors, that provide for administration of medicinal products from a multidose-cartridge and permit a user to set the delivery dose. The injector may include a housing, a piston rod adapted to operate through the housing, a dose dial sleeve located between the housing and the piston rod, and a drive sleeve located between the dose dial sleeve and the piston rod. The dose dial sleeve may have a helical thread of first lead and the drive sleeve may have a helical groove of second lead. The first lead of the helical thread and the second lead of the helical groove may be the same.

Claims

1. A drug delivery device comprising:

a first member comprising (i) a first thread, (ii) a dose dispensing end, and (iii) a stop member that is integral to the first member;

a second member disposed radially inward from the first member, the second member comprising a second thread that engages with the first thread;

a third member disposed radially inward from the second member;

a fourth member disposed radially inward from the third member;

a fifth member engaged with the fourth member, the fifth member comprising a third thread;

a sixth member that is rotationally fixed to the fourth member;

wherein;

the stop member is configured to engage the second member and prevent axial movement of the sixth member away from the dose dispensing end;

the third member is configured to be rotationally fixed to the second member during dose setting;

the fourth member is configured to be rotationally fixed to the third member during dose setting;

the second, third, and fourth members configured to rotate during dose setting;

the fifth member configured to traverse axially during dose dispensing;

the sixth member is configured to be depressed axially towards the dose dispensing end.

2. The drug delivery device of claim 1 wherein the first member comprises a housing.

3. The drug delivery device of claim 1 wherein the second member comprises a dose indicator.

4. The drug delivery device of claim 1 wherein the third member comprises a clutch.

5. The drug delivery device of claim 1 wherein the fourth member comprises a drive sleeve.

6. The drug delivery device of claim 1 wherein the fifth member comprises a piston rod.

7. The drug delivery device of claim 1 wherein the sixth member comprises a button.

8. The drug delivery device of claim 1 where the third member comprises a first set of splines.

9. The drug delivery device of claim 8 where the fourth member comprises a second set of splines that engage with the first set of splines.

10. The drug delivery device of claim 9, wherein the sixth member is configured to be depressed axially towards the dose dispensing end and is configured to disengage the first and the second sets of splines.

11. The drug delivery device of claim 1 wherein the fifth member comprises a rotating member.

12. The drug delivery device of claim 11 wherein the rotating member rotates during dose dispensing.

13. The drug delivery device of claim 1 wherein the first member comprises a main housing.

14. The drug delivery device of claim 1 wherein the third member comprises a tubular member.

15. The drug delivery device of claim 14 wherein the tubular member is located adjacent a distal end of the sixth member.

16. The drug delivery device of claim 15 wherein the tubular member is operatively coupled to the sixth member.

17. The drug delivery device of claim 1 wherein the third member comprises a series of teeth.

18. The drug delivery device of claim 17 wherein the third member comprises a series of circumferentially directed saw teeth.

19. The drug delivery device of claim 1 wherein the third member comprises a flange.

20. The drug delivery device of claim 1 further comprising

a clicker.

21. The drug delivery device of claim 20 wherein the clicker comprises

a cylindrical clicker.

22. The drug delivery device of claim 21 wherein the cylindrical clicker comprises

a flexible helically extending arm, and

a series of directed saw teeth.

23. The drug delivery device of claim 22 wherein the series of directed saw teeth comprise circumferentially directed saw teeth.

24. The drug delivery device of claim 23 wherein the cylindrical clicker further comprises a spring.

25. The drug delivery device of claim 1 wherein the fifth member further comprises a pressure foot located at a first end of the fifth member,

the pressure foot disposed to abut an end of a cartridge piston.

26. The drug delivery device of claim 1, further comprising

a removable cap that is configured to be releasably retained over a portion of the first member,

wherein an outer dimension of the removable cap is similar to an outer dimension of the first member.

27. The drug delivery device of claim 1 wherein the drug delivery device comprises a pen-type injector.

28. The drug delivery device of claim 1 wherein the first member is provided with a window through which part of an outer surface of the second member may be seen.