Multi-chamber leadless pacemaker system with inter-device communication

• US 9,623,251 B2
• Filed: 02/10/2015
• Issued: 04/18/2017
• Est. Priority Date: 02/10/2014
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Stahmann, Jeffrey E.
• Primary Examiner(s): Getzow, Scott
• Application Number:
  US14/618,536
• Publication Number:
  US 20150224315A1
• Time in Patent Office: 798 Days
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions
• CPC Class Codes: A61N 1/3624 occurring in the atrium, i.e. atrial tachycardia
• CPC Class Codes: A61N 1/36592 controlled by the heart rate variability
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/37205 Microstimulators, e.g. implantable through a cannula
• CPC Class Codes: A61N 1/37288 Communication to several implantable medical devices within one patient
• CPC Class Codes: A61N 1/3756 Casings with electrodes thereon, e.g. leadless stimulators

Abstract

Systems and methods for switching modes in a multi-device medical system. In one example, a first leadless cardiac pacemaker (LCP) may be implantable at a ventricular site, and a second leadless cardiac pacemaker (LCP) may be implantable at an atrial site and configured to sensing atrial contractions. The first LCP and the second LCP may be configured to be communicatively coupled such that the first LCP and the second LCP can deliver pacing therapy to the ventricular site in a tracking mode. The first LCP and/or the second LCP may additionally be configured to deliver pacing therapy to the ventricular site in a non-tracking mode if an interval between atrial contractions sensed by the second LCP becomes shorter than a threshold duration.

Claims

1. A leadless cardiac pacemaker system comprising:

a first leadless cardiac pacemaker (LCP) configured to be implantable at a ventricular site;

a second leadless cardiac pacemaker (LCP) configured to be implantable at an atrial site, the second LCP configured to sense atrial contractions;

the first LCP and the second LCP are configured to be communicatively coupled such that the second LCP can communicate sensed atrial contractions to the first LCP;

the first LCP being configured to determine an interval between the atrial contractions that are sensed by the second LCP, the first LCP further configured to change a currently active mode of the leadless cardiac pacemaker system from a tracking mode to a non-tracking mode if the determined interval between the atrial contractions becomes shorter than a lower threshold duration;

wherein the first LCP delivers pacing therapy to the ventricular site in accordance with the currently active mode of the leadless cardiac pacemaker system; and

wherein the first LCP delivers pacing therapy to the ventricular site at a predetermined pacing rate if the determined interval between the atrial contractions becomes longer than an upper threshold duration as a result of loss of communication between the first LCP and the second LCP.

2. The leadless cardiac pacemaker system of claim 1, wherein the first LCP is further configured to change the currently active mode of the leadless cardiac pacemaker system from the non-tracking mode to the tracking mode if the determined interval between the atrial contractions becomes longer than the threshold duration.

3. The leadless cardiac pacemaker system of claim 1, wherein in the tracking mode, the first LCP delivers a pacing pulse to the ventricular site in response to each of the atrial contractions communicated by the second LCP.

4. The leadless cardiac pacemaker system of claim 1, wherein in the non-tracking mode, the first LCP delivers pacing pulses to the ventricular site at a predetermined pacing rate.

5. A method of delivering pacing pulses to a heart of a patient, the method comprising:

sensing two or more atrial events by a first implantable medical device implanted at an atrial site;

determining, by the first implantable medical device, an atrial interval between successive atrial events;

determining, by the first implantable medical device, whether the atrial interval indicates an atrial contraction rate that is above a threshold;

if the atrial contraction rate is below the threshold, communicating the sensed atrial events from the first implantable medical device to a second implantable medical device implanted at a ventricular site, wherein the second implantable medical device is configured to pace a ventricle of the heart in response to the communicated events in a tracking mode;

if the atrial contraction rate that is above the threshold, communicating from the first implantable medical device to the second implantable medical device a command to pace the ventricle of the heart in a non-tracking mode; and

in response to a loss of communication between the first implantable medical device and the second implantable medical device, the second implantable medical device is configured to pace the ventricle of the heart at a predetermined safe rate.

6. The method of claim 5, wherein if the atrial contraction rate is below the threshold, the second implantable medical device is configured to pace the ventricle of the heart in response to each communicated sensed event in the tracking mode.

7. The method of claim 5, wherein if the atrial contraction rate is above the threshold, the second implantable medical device is configured to pace the ventricle of the heart at a predetermined rate in the non-tracking mode.

8. The method of claim 7, wherein if the atrial contraction rate is above the threshold but then falls below the threshold, the second implantable medical device is configured to pace the ventricle of the heart in response to each communicated sensed event in the tracking mode.

9. A method of delivering pacing pulses to a heart of a patient, the method comprising:

sensing a plurality of atrial events by a first implantable medical device;

communicating, by the first medical device to a second implantable medical device, an indication of one or more of the plurality of sensed atrial events;

determining an atrial interval between successive sensed atrial events;

determining whether the atrial interval indicates an atrial contraction rate that is above a threshold;

if the atrial contraction rate is below the threshold, delivering one or more pacing pulses to a ventricle of the heart of the patient by the second implantable medical device according to a first therapy protocol;

if the atrial contraction rate is above the threshold, delivering one or more pacing pulses to the ventricle of the heart of the patient by the second implantable medical device according to a second therapy protocol;

wherein the first implantable medical device is configured to determine whether the atrial contraction rate is above the threshold, and if the first implantable medical device determines that the atrial contraction rate is above the threshold;

communicating from the first implantable medical device to the second implantable medical device a first command to begin delivering one or more pacing pulses according to the second therapy protocol, and not communicating the sensed atrial events from the first implantable medical device to the second implantable medical device in order to conserve energy that would otherwise be consumed by communicating through the body from the first implantable medical device to the second implantable medical device; and

if the first implantable medical device determines that the atrial contraction rate subsequently falls below the threshold; and

communicating from the first implantable medical device to the second implantable medical device a second command to stop the second implantable medical device from delivering one or more pacing pulses according to the second therapy protocol and returning to the first therapy protocol.

10. The method of claim 9, wherein the first therapy protocol comprises delivering a pacing pulse to the ventricle of the heart of the patient in response to each sensed atrial event in a tracking mode.

11. The method of claim 9, wherein the second therapy protocol comprises delivering one or more pacing pulses to the heart of the patient at a predetermined rate in a non-tracking mode.

12. The method of claim 9, wherein determining whether the atrial contraction rate is above a threshold comprises averaging two or more previous atrial intervals.

13. The method of claim 9, wherein the first implantable medical device is a leadless cardiac pacemaker (LCP) positioned in or proximate an atrium of the patient'"'"'s heart.

14. The method of claim 9, wherein the second implantable medical device is a leadless cardiac pacemaker (LCP) positioned in or proximate a ventricle of the patient'"'"'s heart.

15. The method of claim 9, wherein communicating, by the first medical device to the second implantable medical device, an indication of one or more of the plurality of sensed atrial events comprises conductive communication through the patient'"'"'s tissue.

16. A medical device system for delivering pacing pulses to a heart of a patient, the medical device system comprising:

a first implantable medical device implantable at an atrial site and communicatively coupled to a second implanted medical device implantable at a ventricular site, wherein;

the first implantable medical device is configured to;

sense atrial events;

determine, based on the sensed atrial events, an atrial contraction rate;

determine whether the atrial contraction rate is above a threshold;

if the atrial contraction rate is below the threshold, communicate each sensed atrial event to the second implantable medical device; and

if the atrial contraction rate is above the threshold, communicate an artificial sensed atrial event per a first predetermined time period to the second implantable medical device, and

the second implantable medical device is configured to operate in a tracking mode and deliver a pacing pulse in response to receiving each sensed atrial event and in response to receiving each artificial sensed atrial event.

17. The medical device system of claim 16, wherein communicating the artificial sensed atrial event per the first predetermined time period to the second implantable medical device comprises communicating a sensed atrial event after a blanking period following a previous sensed atrial event.

18. The medical device system of claim 16, wherein communicating the artificial sensed atrial event per the first predetermined time period to the second implantable medical device comprises communicating an artificial sensed atrial event to the second implantable medical device once per first predetermined time period.

19. The medical device system of claim 18, wherein the first implantable medical device is further configured to communicate an artificial sensed atrial event to the second implantable medical device if the first implantable medical device does not sense an atrial event within a second predetermined time period following a blanking period as a result of a loss of communication between the first implantable medical device and the second implantable medical device.