Ultrasonic treatment of adipose tissue at multiple depths

• US 9,623,267 B2
• Filed: 03/04/2010
• Issued: 04/18/2017
• Est. Priority Date: 03/04/2009
• Status: Active Grant

• Current Assignee: Solta Medical, Inc. (Bausch Health Cos., Inc.)
• Original Assignee: LipoSonix, Inc. (Bausch Health Cos., Inc.)
• Inventors: Ulric, Tanar, Desilets, Charles S., Little, Blake
• Primary Examiner(s): Chen, Tse
• Assistant Examiner(s): NGUYEN, HIEN NGOC
• Application Number:
  US12/717,818
• Publication Number:
  US 20100249669A1
• Time in Patent Office: 2,602 Days
• Field of Search: 601 3
• CPC Class Codes: A61B 34/30 Surgical robots
• CPC Class Codes: A61N 2007/0008 Destruction of fat cells
• CPC Class Codes: A61N 2007/0082 Scanning transducers
• CPC Class Codes: A61N 2007/0091 with moving parts, e.g. transducers, lenses, reflectors
• CPC Class Codes: A61N 2007/0095 by modifying an excitation signal
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00

Abstract

Methods and apparatus (100) are described for modifying unwanted tissue for cosmetic reasons. The methods provide a non-invasive manner to perform body contouring by destroying adipose tissue while simultaneously causing collagen contraction in a single procedure. Adipose tissue destroyed during the medical procedure may be removed from a treatment volume during the wound healing process, allowing the treatment volume to gradually shrink (22). The gradual shrinkage may promote better skin tone in the treatment area. The procedure may involve multiple treatments to the same treatment area or location.

Claims

1. A method of modifying adipose tissue using high intensity focused ultrasound (HIFU), the method comprising:

determining a volume of adipose tissue to be treated;

identifying a corresponding surface area of skin over said volume of adipose tissue;

moving a therapy head including a HIFU therapy transducer on said surface area of skin; and

transferring the HIFU from the HIFU therapy transducer through a coupling fluid surrounding the HIFU therapy transducer to apply multiple treatments of therapeutic ultrasound energy into said volume of adipose tissue such that a plurality of necrosed tissue cells and denatured collagen fibrils are produced, the multiple treatments occurring at least at two different depths.

2. A method of reducing adipose tissue volume in a patient using high intensity focused ultrasound, the method comprising:

determining a volume of adipose tissue to be treated;

identifying a corresponding surface area of skin over said volume of adipose tissue; and

transferring the high intensity focused ultrasound from a transducer through a coupling fluid surrounding the transducer to apply multiple treatments of high intensity focused ultrasound energy to said area in a manner sufficient to induce the gradual destruction of said adipose tissue and denaturing of collagen fibrils, the energy flux of the multiple treatments being at least 35 J/cm², and the multiple treatments occurring at least at two different depths.

3. A medical ultrasound therapy system for treating a volume of adipose tissue, comprising:

a therapy head including a first chamber, a coupling fluid in the first chamber, and at least one high intensity focused ultrasound transducer surrounded by the coupling fluid in the first chamber, the at least one high intensity focused ultrasound transducer configured to emit high intensity focused ultrasound from the at least one high intensity focused ultrasound transducer through the coupling fluid to the volume of adipose tissue; and

a controller comprising;

a data store storing information about a three dimensional treatment profile for the therapy head; and

a processor coupled to the data store, the processor generating a three dimensional treatment cycle for the therapy head in accordance with the information, the three dimensional treatment cycle including treatments by the therapy head at a plurality of different depths.

4. The system of claim 3, wherein the therapy head comprises:

an enclosure with a partition, the partition defining the first chamber and a second chamber within the enclosure; and

a motor assembly within the second chamber,

wherein the high intensity focused ultrasound transducer is movable within the first chamber through motor commands provided to the motor assembly from the controller.

5. The system of claim 3, wherein the data store further comprises information stored in library tables.

6. The system of claim 3, wherein the data store further comprises profile data particular to various anatomical regions of adipose tissue.

7. The system of claim 6, wherein the profile data is adapted for gender variations.

8. The system of claim 3, wherein the therapy head is adapted for various anatomical regions of adipose tissue.

9. The system of claim 3, wherein the controller is adapted to promote an effect of necrosis of adipose tissue.

10. The system of claim 3, wherein the controller is adapted to promote an effect of denaturing collagen fibrils.

11. A medical ultrasound therapy system for treating a volume of adipose tissue, comprising:

a therapy head including a first chamber, a coupling fluid in the first chamber, and at least one high intensity focused ultrasound transducer surrounded by the coupling fluid in the first chamber, the at least one high intensity focused ultrasound transducer configured to emit high intensity focused ultrasound from the at least one high intensity focused ultrasound transducer through the coupling fluid to the volume of adipose tissue; and

a controller for generating a three dimensional treatment plan for the therapy head, the controller comprising;

a data access component for accessing data defining a three dimensional treatment profile for a treatment of a defined region of a patient, the treatment profile including information about treatments to be conducted at a plurality of different depths; and

a treatment plan component for generating a treatment plan based upon the treatment profile, the treatment plan including treatments defined for the therapy head at the plurality of different depths in accordance with the information.

12. The system of claim 11, wherein the therapy head comprises:

an enclosure with a partition, the partition defining the first chamber and a second chamber within the enclosure; and

a motor assembly within the second chamber,

wherein the high intensity focused ultrasound transducer is movable within the first chamber through motor commands provided to the motor assembly from the controller.

13. The system of claim 11, wherein the data store further comprises information stored in library tables.

14. The system of claim 11, wherein the data store further comprises profile data particular to various anatomical regions of adipose tissue.

15. The system of claim 14, wherein the profile data is adapted for gender variations.

16. The system of claim 11, wherein the therapy head is adapted for various anatomical regions of adipose tissue.

17. The system of claim 11, wherein the controller is adapted to promote an effect of necrosis of adipose tissue.

18. The system of claim 11, wherein the controller is adapted to promote an effect of denaturing collagen fibrils.

19. A method for treating a patient with high intensity focused ultrasound, the method comprising:

positioning a therapy head having at least one high intensity focused ultrasound transducer against a first location on a patient; and

using an automated process;

while at the first location, transferring the high intensity focused ultrasound from the at least one high intensity focused ultrasound transducer through a coupling fluid to ablate the tissue at a first depth; and

while at the first location, transferring the high intensity focused ultrasound from the at least one high intensity focused ultrasound transducer through the coupling fluid in the therapy head to ablate tissue at a second depth.

20. The method of claim 19, wherein the automated process comprises:

accessing information about a plurality of depths profile for the therapy head; and

generating a multi-depth treatment cycle for the therapy head in accordance with the information, the multi-depth treatment cycle including treatments by the therapy head at the plurality of depths.

21. The method of claim 20, wherein the information is stored in library tables.

22. The method of claim 20, wherein the information comprises profile data particular to various anatomical regions of adipose tissue.

23. The method of claim 19, wherein the therapy head comprises:

an enclosure with a partition, the partition defining the first chamber and a second chamber within the enclosure; and

a motor assembly within the second chamber,

wherein the high intensity focused ultrasound transducer is movable within the first chamber through motor command provided to the motor assembly from the controller; and

wherein the automated process comprises the ultrasound transducer moving with the first chamber through motor command.

24. The method of claim 23, wherein the profile data is adapted for gender variations.

25. The method of claim 23, wherein depth variation is provided by varying the focus of the ultrasound transducer.

26. The method of claim 19, wherein ablating tissue comprises promoting an effect of necrosis of adipose tissue.

27. The method of claim 19, wherein ablating tissue comprises promoting promote an effect of denaturing collagen fibrils.

28. A medical ultrasound therapy system, comprising:

a therapy head including a first chamber, a coupling fluid in the first chamber, and at least one high intensity focused ultrasound transducer surrounded by the coupling fluid in the first chamber, the at least one high intensity focused ultrasound transducer configured to emit high intensity focused ultrasound from the at least one high intensity focused ultrasound transducer through the coupling fluid to the volume of adipose tissue; and

a controller comprising;

a data store having stored thereon a data structure, the data structure comprising a tissue ablation treatment routine comprising a first data field containing data representing a routine for first ablation of tissue at a first depth in accordance with the routine and a second data field representing a routine for second ablation of tissue at a second depth in accordance with the routine; and

a processor coupled to the data store, the processor accessing the data structure and instructing the therapy head to perform the routine in an automated process and including the first ablation and the second ablation.

29. The system of claim 28, wherein the therapy head comprises:

an enclosure with a partition, the partition defining the first chamber and a second chamber within the enclosure; and

a motor assembly within the second chamber,

wherein the high intensity focused ultrasound transducer is movable within the first chamber through motor command provided to the motor assembly from the controller.

30. The system of claim 28, wherein the data store further comprises information stored in library tables.

31. The system of claim 28, wherein the data store further comprises profile data particular to various anatomical regions of adipose tissue.

32. The system of claim 31, wherein the profile data is adapted for gender variations.

33. The system of claim 28, wherein the therapy head is adapted for various anatomical regions of adipose tissue.

34. The system of claim 28, wherein the controller is adapted to promote an effect of necrosis of adipose tissue.

35. The system of claim 28, wherein the controller is adapted to promote an effect of denaturing collagen fibrils.